A Review on Notch Signaling and Colorectal Cancer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

(2019) Rene Jackstadt et al.   CANCER CELL

A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors

(2018) R Ferrarotto et al.   ANNALS OF ONCOLOGY

Secretory expression of negative regulatory region of human Notch1 in Escherichia coli and preparation of a functional polyclonal antibody

(2018) Dengyang Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Inhibition of Notch1/Hes1 signaling pathway improves radiosensitivity of colorectal cancer cells

(2018) Hongzhi Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Notch inhibitor screening reveals an unexpected HES1 heterodimer

(2018) Krizia Rohena-Rivera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Doxorubicin combined with Notch1‑targeting siRNA for the treatment of gastric cancer

(2018) Wei Zhou et al.   Oncology Letters

First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer

(2018) C Massard et al.   ANNALS OF ONCOLOGY

The Chemopreventive effect of Withaferin A on spontaneous and Inflammation-associated colon carcinogenesis models

(2018) Balaji Chandrasekaran et al.   CARCINOGENESIS

Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer

(2018) Deeksha Pal et al.   Cell Death & Disease

Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells

(2017) Wangdi Liao et al.   ONCOLOGY REPORTS

HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins

(2017) Lei Sun et al.   Journal of Cancer

NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?

(2016) Tingting Huang et al.   Molecular Cancer

Targeting aberrant expression of Notch-1 in ALDH+cancer stem cells in breast cancer

(2016) Deeksha Pal et al.   MOLECULAR CARCINOGENESIS

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

(2016) Ajinkya Revandkar et al.   Nature Communications

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

(2016) Yingli Shang et al.   Protein & Cell

Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells

(2016) Chiara Fazio et al.   Scientific Reports

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis

(2015) Z. Liu et al.   DEVELOPMENT

ANOTCH1gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer

(2015) John J. Arcaroli et al.   INTERNATIONAL JOURNAL OF CANCER

Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer

(2015) Alexander W. Fender et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner

(2015) Shan Shao et al.   Molecular Cancer

A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors

(2015) Ankur Sharma et al.   Scientific Reports

Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway

(2015) MT Weng et al.   PLoS One

Molecular identification and targeting of colorectal cancer stem cells

(2015)   Oncotarget

Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer

(2015) Jie Huang et al.   Oncotarget

A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors

(2014) D. C. Smith et al.   CLINICAL CANCER RESEARCH

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis

(2013) William K.K. Wu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Notch3 establishes brain vascular integrity by regulating pericyte number

(2013) Y. Wang et al.   DEVELOPMENT

Notch1-dependent regulation of p27 determines cell fate in colorectal cancer

(2013) NEVYANA R. HRISTOVA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Expression of the RNA Helicase DDX3 and the Hypoxia Response in Breast Cancer

(2013) Guus M. Bol et al.   PLoS One

Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway

(2012) Klaus Geissler et al.   ANNALS OF HEMATOLOGY

siRNA-mediated Silencing of Notch-1 Enhances Docetaxel Induced Mitotic Arrest and Apoptosis in PCa Cells

(2012) Qi-Fa Ye et al.   Asian Pacific Journal of Cancer Prevention

Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells

(2012) Ronny Falk et al.   METHODS

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients

(2011) Cristina Raimondi et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Role of Notch signaling in colon homeostasis and carcinogenesis

(2011) Shingo Miyamoto et al.   CANCER SCIENCE

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Notch 1 signaling is active in ovarian cancer

(2010) Stephen L. Rose et al.   GYNECOLOGIC ONCOLOGY

Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate

(2010) Georgios Kallifatidis et al.   MOLECULAR THERAPY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

(2009) Otto Schmalhofer et al.   CANCER AND METASTASIS REVIEWS

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

Epithelial-mesenchymal transition in cancer development and its clinical significance

(2009) Masaaki Iwatsuki et al.   CANCER SCIENCE

Role of Notch signaling in colorectal cancer

(2009) L. Qiao et al.   CARCINOGENESIS

γ-secretase inhibitors: Notch so bad

(2009) Gerard C Grosveld   NATURE MEDICINE

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surgical Management of Colorectal Lung Metastasis

(2009) P. Villeneuve et al.   Clinics in Colon and Rectal Surgery

Requirement of Notch activation during regeneration of the intestinal epithelia

(2008) Ryuichi Okamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells

(2008) Tamara Aleksic et al.   Cell Communication and Signaling

γ-Secretase Inhibition and Modulation for Alzheimers Disease

(2008) Michael Wolfe   Current Alzheimer Research

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells

(2007) Takashi Akiyoshi et al.   GASTROENTEROLOGY