Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Notch Pathway Inhibition Using PF-03084014, a  -Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer

(2015) D. Cui et al.   CLINICAL CANCER RESEARCH

High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells

(2015) Renzhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma

(2015) C Papayannidis et al.   Blood Cancer Journal

Androgen Receptor Promotes the Oncogenic Function of Overexpressed Jagged1 in Prostate Cancer by Enhancing Cyclin B1 Expression via Akt Phosphorylation

(2014) Yongjiang Yu et al.   MOLECULAR CANCER RESEARCH

SCF ubiquitin ligase-targeted therapies

(2014) Jeffrey R. Skaar et al.   NATURE REVIEWS DRUG DISCOVERY

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array

(2013) Charles Vadnais et al.   BMC GENOMICS

Inactivating CUX1 mutations promote tumorigenesis

(2013) Chi C Wong et al.   NATURE GENETICS

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK

(2012) Antonio Maraver et al.   CANCER CELL

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism

(2011) Xinyu Wu et al.   DEVELOPMENTAL BIOLOGY

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

(2011) Jean-René Alattia et al.   FASEB JOURNAL

Down regulation of CSL activity inhibits cell proliferation in prostate and breast cancer cells

(2011) Thomas Yong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL

(2011) M L Sulis et al.   LEUKEMIA

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

(2011) Zhihu Ding et al.   NATURE

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Novel γ-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1

(2010) Fang Wu et al.   FASEB JOURNAL

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Mice Develop Mammary Tumors of Various Histologic Types

(2009) C. Cadieux et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator

(2009) B. Bin Hafeez et al.   CLINICAL CANCER RESEARCH

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

(2009) Y. Yashiro-Ohtani et al.   GENES & DEVELOPMENT

Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia

(2009) Alexandra Szalad et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma

(2008) A. Palumbo et al.   ANNALS OF ONCOLOGY