Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway
Published 2015 View Full Article
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Title
Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway
Authors
Keywords
Colorectal cancer, Small interfering RNAs, Caco-2 cells, Gene expression, HT29 cells, Hyperexpression techniques, Notch signaling, Transfection
Journal
PLoS One
Volume 10, Issue 12, Pages e0144322
Publisher
Public Library of Science (PLoS)
Online
2015-12-10
DOI
10.1371/journal.pone.0144322
References
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- Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
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- STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter
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- Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis
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- (2011) Liang Zhu et al. MEDICAL ONCOLOGY
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- (2010) Yan Zhang et al. CANCER
- NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer
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- Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
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- Hes1/Hes5 Gene Inhibits Differentiation via Down-Regulating Hash1 and Promotes Proliferation in Cervical Carcinoma Cells
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- Up-regulated expression of Notch1 and Jagged1 in human colon adenocarcinoma
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- The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study
- (2009) Xinyu Wang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway
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- Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells
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- (2008) Dake Chu et al. JOURNAL OF GASTROINTESTINAL SURGERY
- Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1
- (2008) L. Sang et al. SCIENCE
- Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene
- (2007) Yuhua Song et al. MOLECULAR IMMUNOLOGY
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