Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury

Phagocytosis: Phenotypically Simple Yet a Mechanistically Complex Process

(2020) Vijay Kumar   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

(2020) Antoine Roquilly et al.   NATURE IMMUNOLOGY

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

(2020) Shiqin Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils Disturb Pulmonary Microcirculation in Sepsis-induced Acute Lung Injury

(2019) Inwon Park et al.   EUROPEAN RESPIRATORY JOURNAL

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

The effect of diabetes on the risk and mortality of acute lung injury/acute respiratory distress syndrome

(2019) Mingxia Ji et al.   MEDICINE

Airway macrophages as the guardians of tissue repair in the lung

(2019) Franz Puttur et al.   IMMUNOLOGY AND CELL BIOLOGY

Innate Lymphoid Cells of the Lung

(2019) Jillian L. Barlow et al.   Annual Review of Physiology

miR-142 controls metabolic reprogramming that regulates dendritic cell activation

(2019) Yaping Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

A STING to inflammation and autoimmunity

(2019) Vijay Kumar   JOURNAL OF LEUKOCYTE BIOLOGY

Pathogenesis of Acute Respiratory Distress Syndrome

(2019) Laura Huppert et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair

(2019) Andrew S. Kimball et al.   IMMUNITY

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism

(2019) Rendong Fang et al.   Mucosal Immunology

STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation

(2019) Saroj Nepal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Lymphoid Cells in Mucosal Immunity

(2019) Santosh K. Panda et al.   Frontiers in Immunology

NK Cells in the Human Lungs

(2019) Baptiste Hervier et al.   Frontiers in Immunology

Airway M Cells Arise in the Lower Airway Due to RANKL Signaling and Reside in the Bronchiolar Epithelium Associated With iBALT in Murine Models of Respiratory Disease

(2019) Shunsuke Kimura et al.   Frontiers in Immunology

Natural Killer Cells in the Lungs

(2019) Jingjing Cong et al.   Frontiers in Immunology

Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace

(2019) Wan-Chi Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia

(2019) Kazuo Tsuchiya et al.   Scientific Reports

Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells

(2018) Li-Yin Hung et al.   AMERICAN JOURNAL OF PATHOLOGY

Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis

(2018) Tristen T. Chun et al.   AMERICAN JOURNAL OF PATHOLOGY

Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1

(2018) Yang Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection

(2018) Soo Jung Cho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IFN-β Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome–related Mortality

(2018) Takahiro Hiruma et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection

(2018) Soo Jung Cho et al.   EXPERIMENTAL GERONTOLOGY

Interleukin-33 contributes to ILC2 activation and early inflammation-associated lung injury during abdominal sepsis

(2018) Hui Xu et al.   IMMUNOLOGY AND CELL BIOLOGY

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

(2018) Kumar Vijay   INTERNATIONAL IMMUNOPHARMACOLOGY

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia

(2018) Ho Pan Sham et al.   JOURNAL OF IMMUNOLOGY

Mucosal Immune Response in Nasal-Associated Lymphoid Tissue upon Intranasal Administration by Adjuvants

(2018) Hiromi Takaki et al.   Journal of Innate Immunity

B-1a cells protect mice from sepsis-induced acute lung injury

(2018) Monowar Aziz et al.   MOLECULAR MEDICINE

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

(2018) Yuefeng Huang et al.   SCIENCE

SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy

(2018) André Veillette et al.   TRENDS IN IMMUNOLOGY

Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis

(2018) Dengming Lai et al.   Cell Death & Disease

Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance

(2018) Ranferi Ocaña-Guzman et al.   Journal of Immunology Research

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

(2018) Bishuang Cai et al.   Science Signaling

The first line of defence: insights into mechanisms and relevance of phagocytosis in epithelial cells

(2018) Juliane Günther et al.   Seminars in Immunopathology

NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function

(2018) Laxman Ghimire et al.   PLoS Pathogens

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Innate Lymphoid Cells Have Decreased HLA-DR Expression but Retain Their Responsiveness to TLR Ligands during Sepsis

(2018) David Cruz-Zárate et al.   JOURNAL OF IMMUNOLOGY

NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during Gram-positive pneumonia

(2018) Sagar Paudel et al.   Mucosal Immunology

Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta

(2018) Sanne L. Maas et al.   Frontiers in Immunology

ILC2s — resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move?

(2018) Ronald N Germain et al.   CURRENT OPINION IN IMMUNOLOGY

Lung Homeostasis: Influence of Age, Microbes, and the Immune System

(2017) Clare M. Lloyd et al.   IMMUNITY

Local Modulation of Antigen-Presenting Cell Development after Resolution of Pneumonia Induces Long-Term Susceptibility to Secondary Infections

(2017) Antoine Roquilly et al.   IMMUNITY

Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells

(2017) Yanxiang Li et al.   IMMUNOBIOLOGY

Gram-positive pneumonia augments non-small cell lung cancer metastasis via host toll-like receptor 2 activation

(2017) Stephen D. Gowing et al.   INTERNATIONAL JOURNAL OF CANCER

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69 − CD56 dim cells

(2017) Nicole Marquardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung epithelial cells: therapeutically inducible effectors of antimicrobial defense

(2017) M M Leiva-Juárez et al.   Mucosal Immunology

Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection

(2017) K M Robinson et al.   Mucosal Immunology

Neonatal gut microbiota induces lung immunity against pneumonia

(2017) Sabrina Tamburini et al.   Nature Reviews Gastroenterology & Hepatology

Acute Lung Failure — Our Evolving Understanding of ARDS

(2017) Gordon Bernard   NEW ENGLAND JOURNAL OF MEDICINE

Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection

(2017) Jerilyn Gray et al.   Science Translational Medicine

Resveratrol alleviates Staphylococcus�aureus pneumonia by inhibition of the NLRP3 inflammasome

(2017) Suxia Wu et al.   Experimental and Therapeutic Medicine

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

(2017) Medya Mara Shikhagaie et al.   Cell Reports

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment

(2017) Simona Saluzzo et al.   Cell Reports

Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection

(2017) Masa Ivin et al.   PLoS Pathogens

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial

(2017) Daniel F McAuley et al.   Lancet Respiratory Medicine

Innate Lymphoid Cells: Immunoregulatory Cells of Mucosal Inflammation

(2017) V. Kumar   European Journal of Inflammation

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

(2016) Jatinder K. Juss et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease

(2016) Seonmin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epithelial Cell–Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia

(2016) Hirofumi Kamata et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Innate Lymphocyte/Ly6C hi Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance

(2016) Huizhong Xiong et al.   CELL

Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion

(2016) Natalia Muñoz-Wolf et al.   Future Microbiology

Complement resistance mechanisms of Klebsiella pneumoniae

(2016) Dennis J. Doorduijn et al.   IMMUNOBIOLOGY

Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection

(2016) Ana CG Salina et al.   Innate Immunity

Community-acquired pneumonia related to intracellular pathogens

(2016) Catia Cillóniz et al.   INTENSIVE CARE MEDICINE

CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling

(2016) Kazuhide Hayakawa et al.   JOURNAL OF NEUROCHEMISTRY

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

(2016) Yoichiro Ohne et al.   NATURE IMMUNOLOGY

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

(2016) Suzanne M Bal et al.   NATURE IMMUNOLOGY

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

(2016) Jonathan S Silver et al.   NATURE IMMUNOLOGY

Role of Atypical Pathogens in the Etiology of Community-Acquired Pneumonia

(2016) Forest Arnold et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

The Epithelium as a Target in Sepsis

(2016) Lakhmir S. Chawla et al.   SHOCK

The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome

(2016) David A Dorward et al.   THORAX

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

(2016) Adam J. Byrne et al.   TRENDS IN MOLECULAR MEDICINE

ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus α-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes

(2016) Ejiofor Ezekwe et al.   Toxins

Respiratory Microbiome of New-Born Infants

(2016) David J. Gallacher et al.   Frontiers in Pediatrics

Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung

(2016) Katrien C. De Grove et al.   PLoS One

Sirt1 restrains lung inflammasome activation in a murine model of sepsis

(2015) Rong Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections

(2015) Rémi Porte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Interleukin-12 in Protection against Pulmonary Infection with Methicillin-Resistant Staphylococcus aureus

(2015) Quang-Tam Nguyen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinct Molecular Phenotypes of Direct vs Indirect ARDS in Single-Center and Multicenter Studies

(2015) Carolyn S. Calfee et al.   CHEST

Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin

(2015) Norman F. Russkamp et al.   FASEB JOURNAL

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

(2015) Laura Denney et al.   IMMUNITY

Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia

(2015) Stefanie Gauguet et al.   INFECTION AND IMMUNITY

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-γ

(2015) Miriam H.P. van Lieshout et al.   Journal of Innate Immunity

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Pulmonary macrophages: key players in the innate defence of the airways

(2015) Adam J Byrne et al.   THORAX

Investigating the Role of Nucleotide-Binding Oligomerization Domain–Like Receptors in Bacterial Lung Infection

(2014) Mary Leissinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

(2014) J Xu et al.   CELL DEATH AND DIFFERENTIATION

Development, Differentiation, and Diversity of Innate Lymphoid Cells

(2014) Andreas Diefenbach et al.   IMMUNITY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Alveolar Macrophages from Septic Mice Promote Polymorphonuclear Leukocyte Transendothelial Migration via an Endothelial Cell Src Kinase/NADPH Oxidase Pathway

(2014) Z. Wang et al.   JOURNAL OF IMMUNOLOGY

Conventional NK Cells Can Produce IL-22 and Promote Host Defense in Klebsiella pneumoniae Pneumonia

(2014) X. Xu et al.   JOURNAL OF IMMUNOLOGY

Activation of Type 3 Innate Lymphoid Cells and Interleukin 22 Secretion in the Lungs During Streptococcus pneumoniae Infection

(2014) Laurye Van Maele et al.   JOURNAL OF INFECTIOUS DISEASES

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

(2014) Christopher Schliehe et al.   NATURE IMMUNOLOGY

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

(2014) Eva S Gollwitzer et al.   NATURE MEDICINE

Risk of Acute Lung Injury/Acute Respiratory Distress Syndrome in Critically Ill Adult Patients with Pre-Existing Diabetes: A Meta-Analysis

(2014) Wan-Jie Gu et al.   PLoS One

Biomarkers in acute respiratory distress syndrome: from pathobiology to improving patient care

(2014) James M Walter et al.   Expert Review of Respiratory Medicine

New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease

(2013) Dominic De Nardo et al.   AMERICAN JOURNAL OF PATHOLOGY

The mercurial nature of neutrophils: still an enigma in ARDS?

(2013) Andrew E. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Signalling C-Type lectin receptors, microbial recognition and immunity

(2013) J. Claire Hoving et al.   CELLULAR MICROBIOLOGY

Role of Diabetes in the Development of Acute Respiratory Distress Syndrome*

(2013) Shun Yu et al.   CRITICAL CARE MEDICINE

Innate lymphoid cells: New paradigm in immunology of inflammation

(2013) Vijay Kumar   IMMUNOLOGY LETTERS

Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia

(2013) Taylor S. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistent organ dysfunction after severe sepsis: A systematic review

(2013) Faheem W. Guirgis et al.   JOURNAL OF CRITICAL CARE

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages

(2013) Jian Wang et al.   Nature Communications

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

NOD-Like Receptors in Lung Diseases

(2013) Catherine Chaput et al.   Frontiers in Immunology

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins

(2013) Driss El Kebir et al.   Frontiers in Immunology

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis

(2012) A. Mildner et al.   BLOOD

Neutrophils in acute lung injury

(2012) Xiao et al.   Frontiers in Bioscience-Landmark

Lung natural killer cells in mice: phenotype and response to respiratory infection

(2012) Jian Wang et al.   IMMUNOLOGY

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

(2012) Jeremy A. Hirota et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

(2012) Marsha Wills-Karp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired NLRP3 Inflammasome Function in Elderly Mice during Influenza Infection Is Rescued by Treatment with Nigericin

(2012) H. W. Stout-Delgado et al.   JOURNAL OF IMMUNOLOGY

NLRC4 Inflammasome-Mediated Production of IL-1  Modulates Mucosal Immunity in the Lung against Gram-Negative Bacterial Infection

(2012) S. Cai et al.   JOURNAL OF IMMUNOLOGY

Trefoil Factor 2 Negatively Regulates Type 1 Immunity against Toxoplasma gondii

(2012) C. McBerry et al.   JOURNAL OF IMMUNOLOGY

Differential Roles of MyD88 and TRIF in Hematopoietic and Resident Cells During Murine Gram-Negative Pneumonia

(2012) Miriam H. P. van Lieshout et al.   JOURNAL OF INFECTIOUS DISEASES

Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

(2012) Chahnaz Kebaier et al.   JOURNAL OF INFECTIOUS DISEASES

Tissue-Specific Neutrophil Recruitment into the Lung, Liver, and Kidney

(2012) Jan Rossaint et al.   Journal of Innate Immunity

Airway CD8+ T cells induced by pulmonary DNA immunization mediate protective anti-viral immunity

(2012) M Bivas-Benita et al.   Mucosal Immunology

Sepsis Enhances Epithelial Permeability with Stretch in an Actin Dependent Manner

(2012) Taylor S. Cohen et al.   PLoS One

Sepsis-Induced Acute Lung Injury (ALI) Is Milder in Diabetic Rats and Correlates with Impaired NFkB Activation

(2012) Luciano R. Filgueiras et al.   PLoS One

Absence of Integrin αvβ3 Enhances Vascular Leak in Mice by Inhibiting Endothelial Cortical Actin Formation

(2011) George Su et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

The Natural Cytotoxicity Receptor 1 Contribution to Early Clearance of Streptococcus pneumoniae and to Natural Killer-Macrophage Cross Talk

(2011) Shirin Elhaik-Goldman et al.   PLoS One

Acute Lung Injury: How Macrophages Orchestrate Resolution of Inflammation and Tissue Repair

(2011) Susanne Herold et al.   Frontiers in Immunology

CCR6 identifies lymphoid tissue inducer cells within cryptopatches

(2010) A. Lügering et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Diabetes, insulin, and development of acute lung injury

(2010) Shyoko Honiden et al.   CRITICAL CARE MEDICINE

The Mysterious Ways of the Chemokine CXCL5

(2010) Ekaterina K. Koltsova et al.   IMMUNITY

CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection

(2010) Junjie Mei et al.   IMMUNITY

Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection

(2010) N. Munoz et al.   INFECTION AND IMMUNITY

Acute Lung Inflammation in Klebsiella pneumoniae B5055-Induced Pneumonia and Sepsis in BALB/c Mice: A Comparative Study

(2010) Vijay Kumar et al.   INFLAMMATION

CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via CXCL2, CXCL5, NF- B, and MAPKs

(2010) S. Cai et al.   JOURNAL OF IMMUNOLOGY

IRAK-M Regulates Chromatin Remodeling in Lung Macrophages during Experimental Sepsis

(2010) Kenneth Lyn-Kew et al.   PLoS One

Genetic immunization in the lung induces potent local and systemic immune responses

(2010) K. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1

(2009) Guofei Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Macrophage Tumor Necrosis Factor-α Induces Epithelial Expression of Granulocyte–Macrophage Colony-stimulating Factor

(2009) Lidija Cakarova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial cell death effectors

(2009) Dirk Brenner et al.   CURRENT OPINION IN CELL BIOLOGY

M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis

(2009) Sinead C. Corr et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Connexin43 modulates neutrophil recruitment to the lung

(2009) Maya Z. Richani Sarieddine et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling

(2009) Alexandra I. Medeiros et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Both TRIF- and MyD88-Dependent Signaling Contribute to Host Defense against Pulmonary Klebsiella Infection

(2009) S. Cai et al.   JOURNAL OF IMMUNOLOGY

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation

(2009) Nathalie Koning et al.   Journal of Innate Immunity

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Transepithelial Migration of Neutrophils

(2008) Rachel L. Zemans et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Interleukin-12 and Host Defense against Murine Pneumocystis Pneumonia

(2008) S. Ruan et al.   INFECTION AND IMMUNITY

Macrophage Turnover Kinetics in the Lungs of Mice Infected with Streptococcus pneumoniae

(2007) Katharina Taut et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY