Article
Medicine, Research & Experimental
Pei-Shan Sung, Yu-Chun Peng, Shao-Ping Yang, Cheng-Hsun Chiu, Shie-Liang Hsieh
Summary: A study found that CLEC5A interacts with Pseudomonas aeruginosa's LPS, leading to the formation of neutrophil extracellular traps (NETs) and lung inflammation. Blocking CLEC5A can reduce Pseudomonas aeruginosa-induced NETosis and lung injury, and co-administration with ciprofloxacin improves survival rate in mice.
Article
Cell Biology
Xuyue Zhou, Yu Hu, Lingxi Liu, Lihao Liu, Hongying Chen, Dan Huang, Mei Ju, Chao Luan, Kun Chen, Jiaan Zhang
Summary: This study found that mast cells play a role in exacerbating skin inflammation in psoriasis, by regulating the inflammatory state and immune homeostasis. The results suggest that targeting mast cell homeostasis could be a potential therapeutic strategy for psoriasis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Felipe Villanelo, Jorge Carrasco, Joaquin Jensen-Flores, Jose Antonio Garate, Tomas Perez-Acle
Summary: Connexin hemichannels facilitate the exchange of molecules such as ions, water, and ATP between eukaryotic cells and their extracellular space. Regulation of these channels by extracellular Ca2+ concentration is known to influence their open or closed state, but the exact mechanisms involved are still not fully understood. Studies using molecular dynamics simulations suggest that pore stretching at the center of the connexin hemichannels may be the key factor in channel blocking, rather than the addition of positive charge density inside the channel.
Article
Cell Biology
Pei Xiong Liew
Summary: Inflammation-induced kidney damage is a major cause of proliferative glomerulonephritis, and the immune response plays a crucial role in patient outcomes and effective treatment. Neutrophils are significant in responding to infection or injury, and their recruitment to the kidney environment requires careful regulation to avoid nonspecific damage. The unique microvasculature of the kidney influences neutrophil recruitment, and advancements in live-animal imaging have revealed novel pathways of recruitment in the kidney, particularly in the glomeruli.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Cell Biology
Nishant Ranjan Chauhan, Soumya Kundu, Ramyasing Bal, Diya Chattopadhyay, Rinku Sahu, Subhash Mehto, Rina Yadav, Sivaram Krishna, Kautilya Kumar Jena, Sameekshya Satapathy, Anusha Pv, Krushna C. Murmu, Bharati Singh, Srinivas Patnaik, Sarita Jena, Krishnan H. Harshan, Gulam Hussain Syed, Mohammed M. Idris, Punit Prasad, Santosh Chauhan
Summary: Interferon Type I (IFN-I) response plays a crucial role in host defense against SARS-CoV-2 infection. Through mouse models, it has been found that a high level of IFN-I response can protect against lethal SARS-CoV-2 infection, while a dampened IFN-I response may lead to severe infection and immune inflammation.
Article
Medicine, Research & Experimental
Danilo B. M. Lucchi, Gisela R. S. Sasso, Leticia S. Sena, Diego D. Santos, Paulo C. Franco, Izabella Lice, Fernanda T. Borges, Sonia M. Oliani, Cristiane D. Gil
Summary: In this study, the pharmacological treatment with AnxA1-derived peptide Ac2-26 was evaluated in an experimental model of cisplatin-induced toxicity. The results showed that Ac2-26 treatment could alleviate the inflammatory response induced by cisplatin and protect the liver and kidneys from cisplatin-induced damage. However, the peptide treatment had no significant effect on kidney morphology injury.
Article
Immunology
Andrea L. Graham
Summary: Laboratory mice provide valuable insights into mammalian immune systems, but their immune phenotypes often differ from wild mammals. Recent efforts to naturalize the environment of inbred mice are poised to enhance understanding of natural selection's impact on immune systems.
Article
Cell Biology
Elena Roger, Christos E. Chadjichristos, Panagiotis Kavvadas, Gareth W. Price, Chelsy L. Cliff, Safia Hadjadj, Jessy Renciot, Paul E. Squires, Claire E. Hills
Summary: Background: Chronic kidney disease is a global public health issue due to the lack of effective treatments. Multiple cell types contribute to the inflammatory damage in and around the renal tubules. This study found that aberrant Cx43 hemichannel activity is associated with tubule inflammation. The aim of this study was to investigate whether Cx43 hemichannels play a role in the activation and priming of the NLRP3 inflammasome during the inflammatory process. Through the use of a nephrology database, analysis of human kidney disease tissues, and experiments with the unilateral ureteral obstruction (UUO) mouse model and Cx43 hemichannel blockers, it was found that Cx43 hemichannels play a significant role in tubule injury.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Yue Wang, Ruiwei Ye, Liming Fan, Xin Zhao, Linxue Li, Hao Zheng, Yan Qiu, Xiuxia He, Yiming Lu
Summary: The study demonstrates that an anti-tumor necrosis factor-alpha (TNF-α) peptide, SN1-13, has anti-inflammatory activity by inhibiting TNF-α-induced cytotoxicity and blocking TNF-α-triggered signaling pathways. Molecular docking analysis also suggests that SN1-13 can disrupt the binding between TNF-α and its receptors, TNFR1 and TNFR2. These findings indicate that SN1-13 has potential as a therapeutic peptide for TNF-α-mediated inflammatory diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Ting Shang, Zhi-Sen Zhang, Xin-Tong Wang, Jing Chang, Meng-En Zhou, Ming Lyu, Shuang He, Jian Yang, Yan-Xu Chang, Yuefei Wang, Ming-Chun Li, Xiumei Gao, Yan Zhu, Yuxin Feng
Summary: The study demonstrates that XBJ can inhibit NETs formation by reversing the GSDMD-related pathway and protect against sepsis-induced lung injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Ke Wang, Yue Liao, Xiaoou Li, Ran Wang, Zijian Zeng, Mengxin Cheng, Lijuan Gao, Dan Xu, Fuqiang Wen, Tao Wang, Jun Chen
Summary: Chronic obstructive pulmonary disease (COPD) is a global public health challenge caused by significant exposure to noxious agents, especially cigarette smoke. Excessive production of neutrophil extracellular traps (NETs) in the airways is associated with the severity of COPD. In this study, the inhibitor GW311616A was found to effectively prevent cigarette smoke-induced NET formation in human neutrophil cells by blocking the nuclear translocation of neutrophil elastase (NE) and subsequent chromatin decondensation. Inhibition of NE also improved lung function and attenuated COPD-related pathological changes in a mouse model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Franciel Batista Felix, Julia Dias, Juliana Priscila Vago, Debora Gonzaga Martins, Vinicius Amorim Beltrami, Debora de Oliveira Fernandes, Anna Clara Paiva Menezes dos Santos, Celso Martins Queiroz, Lirlandia Pires de Sousa, Flavio Almeida Amaral, Frederico Marianetti Soriani, Mauro Martins Teixeira, Vanessa Pinho
Summary: Inflammation resolution involves cellular events such as apoptosis and efferocytosis, and the HGF/MET axis plays a crucial role in determining the progression and severity of inflammatory and immune-mediated disorders. Blocking the HGF/MET signalling pathway by PF-04217903 has been shown to promote the resolution of neutrophilic inflammation in models of gout and LPS-induced pleurisy, leading to reduced neutrophil accumulation, increased neutrophil apoptosis and efferocytosis, enhanced expression of Annexin A1, and decreased levels of inflammation markers. These findings suggest that blocking HGF/MET signalling could be a potential therapeutic strategy for resolving neutrophilic inflammatory responses.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Shi-Peng Li, Xin-Qiang Li, Xiao-Jie Chen, Jin-Ming Zhang, Guang-Peng Zhou, Liu-Xin Zhou, Hai-Ming Zhang, Li-Ying Sun, Zhi-Jun Zhu
Summary: This study investigated the proinflammatory cytokines and differentially expressed proteins in a mouse model of liver transplantation using a protein chip system and proteomics. Bioinformatics analysis was employed to analyze the immune response activation-associated network. The results revealed significant changes in cytokine levels and identified key proteins associated with liver transplant rejection. These findings provide new insights and potential treatment targets for liver transplant rejection.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Henna Myllymaki, Peiyi (Pearl) Yu, Yi Feng
Summary: Appropriate neutrophil function is crucial for immune defense and inflammation prevention. Zebrafish larvae have been utilized to study the development and function of neutrophils, offering opportunities to enhance our understanding of neutrophil function in health and disease.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
L. Zhang, Y. Ye, H. Kang, J. Pan, Q. Xu, H. Zhu, G. Liu, W. Gu
Summary: This study systematically evaluated different compounds-induced acute lung injury models and found distinct characteristics associated with viral infection-induced lung injury. These findings may contribute to a better understanding of viral infection-induced acute lung injury.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Marc Chanson, Masakatsu Watanabe, Erin M. O'Shaughnessy, Alice Zoso, Patricia E. Martin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Respiratory System
Bradley H. Rosen, Marc Chanson, Lara R. Gawenis, Jinghua Liu, Aderonke Sofoluwe, Alice Zoso, John F. Engelhardt
JOURNAL OF CYSTIC FIBROSIS
(2018)
Article
Respiratory System
Pascal Barbry, Amelie Cavard, Marc Chanson, Aron B. Jaffe, Lindsey W. Plasschaert
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Multidisciplinary Sciences
Aderonke Sofoluwe, Marc Bacchetta, Mehdi Badaoui, Brenda R. Kwak, Marc Chanson
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Alice Zoso, Aderonke Sofoluwe, Marc Bacchetta, Marc Chanson
Article
Cell Biology
Mehdi Badaoui, Alice Zoso, Tahir Idris, Marc Bacchetta, Juliette Simonin, Sylvain Lemeille, Bernhard Wehrle-Haller, Marc Chanson
Article
Respiratory System
Aderonke Sofoluwe, Alice Zoso, Marc Bacchetta, Sylvain Lemeille, Marc Chanson
Summary: This study investigated the gene expression profile of CFTR knocked down airway epithelial cells in response to bacterial and viral challenges, revealing key molecular pathways and signaling involved in antiviral and antibacterial responses. The findings provide insights into the defective immune response in CF airway epithelium during infection.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Cell Biology
Juliette L. Simonin, Alexandre Luscher, Davide Losa, Mehdi Badaoui, Christian van Delden, Thilo Kohler, Marc Chanson
Summary: Defective hydration of airway surface mucosa is associated with recurrent lung infection in cystic fibrosis. The presence of a healthy airway surface liquid can prevent infection.
Article
Respiratory System
Marco Cafora, Marc Chanson, Anna Pistocchi
Summary: Cystic fibrosis (CF) is a common life-threatening genetic disorder in Caucasians caused by mutations in the CFTR gene. CFTR dysfunction affects mucus- and sweat-producing epithelia, leading to various organ complications. The disease is associated with microbiota dysbiosis and abnormal epithelial homeostasis. New strategies are needed to combat bacterial infections and restore epithelial homeostasis in CF patients, and alternative cutting-edge approaches to modulator therapy are promising.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Medicine, Research & Experimental
Mehdi Badaoui, Cyril Sobolewski, Alexandre Luscher, Marc Bacchetta, Thilo Kohler, Christian van Delden, Michelangelo Foti, Marc Chanson
Summary: Cystic fibrosis (CF) is a chronic respiratory disease caused by bacterial infections, with Pseudomonas aeruginosa (Pa) being the main pathogen. The overexpression of Vav3, a guanine nucleotide exchange factor, is induced by the upregulation of mRNA-stabilizing protein HuR in CF patients. The accumulation of HuR in the cytoplasm of CF airway epithelial cells stabilizes Vav3 mRNA, leading to the formation of fibronectin-made bacterial docking platforms and Pa adhesion. Targeting HuR could be a promising strategy to prevent Pa infection in CF.
Article
Cardiac & Cardiovascular Systems
Olga M. Rusiecka, Filippo Molica, Morten S. Nielsen, Axel Tollance, Sandrine Morel, Maud Frieden, Marc Chanson, Kerstin Boengler, Brenda R. Kwak
Summary: This study found that deletion of the Pannexin1 (Panx1) gene in cardiac endothelial cells can alleviate cardiac ischaemia/reperfusion (I/R) injury and improve left ventricular function recovery. This cardioprotective effect seems to be mediated through its influence on cardiac mitochondria rather than reducing the inflammatory response. Therefore, Panx1 may represent a new target for controlling cardiac reperfusion damage.
CARDIOVASCULAR RESEARCH
(2023)
Correction
Multidisciplinary Sciences
Thilo Koehler, Alexandre Luscher, Lena Falconnet, Gregory Resch, Robert McBride, Quynh-Anh Mai, Juliette L. L. Simonin, Marc Chanson, Bohumil Maco, Raphael Galiotto, Arnaud Riat, Natacha Civic, Mylene Docquier, Shawna McCallin, Benjamin Chan, Christian van Delden
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Thilo Kohler, Alexandre Luscher, Lena Falconnet, Gregory Resch, Robert McBride, Quynh-Anh Mai, Juliette L. Simonin, Marc Chanson, Bohumil Maco, Raphael Galiotto, Arnaud Riat, Shawna McCallin, Benjamin Chan, Christian van Delden
Summary: The study documents the successful treatment of a male patient with life-threatening multi-drug resistant Pseudomonas aeruginosa infection using personalized phage therapy and intravenous antibiotics. This indicates that phage therapy can be an alternative or complementary strategy for multidrug resistant bacterial infections.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Mehdi Badaoui, Marc Chanson
Summary: Connexins and pannexins are transmembrane proteins involved in intercellular communication and play important roles in tissue homeostasis and host defense. Dysregulation of connexin/pannexin channels has been implicated in pulmonary inflammatory diseases, affecting intercellular communication and contributing to pathological changes. Connexins and pannexins may also have a role in shaping the integrity of the airway epithelium, which is crucial for protection against microbial invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elise Dreano, Marc Bacchetta, Juliette Simonin, Louise Galmiche, Claire Usal, Lotfi Slimani, Jeremy Sadoine, Laurent Tesson, Ignacio Anegon, Jean-Paul Concordet, Aurelie Hatton, Lucile Vignaud, Danielle Tondelier, Isabelle Sermet-Gaudelus, Marc Chanson, Charles-Henry Cottart
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2019)