Cathelicidins Modulate TLR-Activation and Inflammation

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

(2020) Franziska Herster et al.   Nature Communications

Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties

(2020) Salma Al-Adwani et al.   Scientific Reports

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

(2019) Ernest Y. Lee et al.   Nature Communications

Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines

(2019) Maia Marin et al.   CELL AND TISSUE RESEARCH

Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

(2019) Brian J. McHugh et al.   PLoS Pathogens

Plasmacytoid Dendritic Cells Provide Protection Against Bacterial-Induced Colitis

(2019) Tania Rahman et al.   Frontiers in Immunology

Synthetic Cationic Peptide IDR-1002 and Human Cathelicidin LL37 Modulate the Cell Innate Response but Differentially Impact PRRSV Replication in vitro

(2019) Benoît Levast et al.   Frontiers in Veterinary Science

Synthetic cathelicidin LL-37 reduces Mycobacterium avium subsp. paratuberculosis internalization and pro-inflammatory cytokines in macrophages

(2019) Karina M. Cirone et al.   CELL AND TISSUE RESEARCH

Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells

(2019) Beatrice Lazzaretto et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Activate Autoreactive B Cells in Lupus

(2018) Nicolas Gestermann et al.   JOURNAL OF IMMUNOLOGY

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

Synergy effects of Polyinosinic-polycytidylic acid, CpG oligodeoxynucleotide, and cationic peptides to adjuvant HPV E7 epitope vaccine through preventive and therapeutic immunization in a TC-1 grafted mouse model

(2018) Cunbao Liu et al.   Human Vaccines & Immunotherapeutics

Cathelicidin-Derived Antimicrobial Peptides Inhibit Zika Virus Through Direct Inactivation and Interferon Pathway

(2018) Miao He et al.   Frontiers in Immunology

Understanding early TLR signaling through the Myddosome

(2018) Katherine R. Balka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cathelicidins InhibitEscherichia coli–Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner

(2017) Maarten Coorens et al.   JOURNAL OF IMMUNOLOGY

Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium

(2017) Maia Marin et al.   MOLECULAR IMMUNOLOGY

Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory response in a mouse septic model

(2017) Hiroshi Hosoda et al.   Molecular Medicine Reports

Intranasal vaccination with an adjuvanted polyphosphazenes nanoparticle-based vaccine formulation stimulates protective immune responses in mice

(2017) Kai Schulze et al.   Nanomedicine-Nanotechnology Biology and Medicine

Induction of a balanced IgG1/IgG2 immune response to an experimental challenge with Mycoplasma bovis antigens following a vaccine composed of Emulsigen™, IDR peptide1002, and poly I:C

(2017) Tracy Prysliak et al.   VACCINE

The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens

(2017) Brandon J. H. Banaschewski et al.   Scientific Reports

BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance

(2017) Masayuki Kuraoka et al.   Cell Reports

Mechanisms and Regulation of Extracellular DNA Release and Its Biological Roles in Microbial Communities

(2017) Alejandra L. Ibáñez de Aldecoa et al.   Frontiers in Microbiology

TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells

(2017) Amy N. Suthers et al.   Frontiers in Immunology

Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response

(2017) Viktoria A. F. Schneider et al.   mSphere

Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis

(2017) Maarten Coorens et al.   Scientific Reports

Killing of Trypanozoon Parasites by the Equine Cathelicidin eCATH1

(2016) S. Cauchard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis

(2016) Xianwei Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells

(2016) Hiroyuki TADA et al.   BIOMEDICAL RESEARCH-TOKYO

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages

(2016) Alexander Stephan et al.   IMMUNOLOGY

Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice

(2016) Zhongshuang Hu et al.   INTERNATIONAL IMMUNOLOGY

Human Host Defense Cathelicidin Peptide LL-37 Enhances the Lipopolysaccharide Uptake by Liver Sinusoidal Endothelial Cells without Cell Activation

(2016) Kaori Suzuki et al.   JOURNAL OF IMMUNOLOGY

Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice

(2016) YUAN-YUAN DENG et al.   Molecular Medicine Reports

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Imaging the antimicrobial mechanism(s) of cathelicidin-2

(2016) Viktoria A. F. Schneider et al.   Scientific Reports

The Role of Cathelicidin LL-37 in Cancer Development

(2015) Ewelina Piktel et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing ofMycobacterium tuberculosisin human macrophages

(2015) Rokeya Sultana Rekha et al.   Autophagy

EDTA-mediated inhibition of DNases protects circulating cell-free DNA from ex vivo degradation in blood samples

(2015) Gustavo Barcelos Barra et al.   CLINICAL BIOCHEMISTRY

Toll-Like Receptor Pathways in Autoimmune Diseases

(2015) Ji-Qing Chen et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Toll-like receptors: Activation, signalling and transcriptional modulation

(2015) Dominic De Nardo   CYTOKINE

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

(2015) Jia Sun et al.   IMMUNITY

In Vivo Role of TLR2 and MyD88 Signaling in Eliciting Innate Immune Responses in Staphylococcal Endophthalmitis

(2015) D. Talreja et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation

(2015) Maarten Coorens et al.   JOURNAL OF IMMUNOLOGY

Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways

(2015) Nikhil N. Kulkarni et al.   MOLECULAR IMMUNOLOGY

Liquid-crystalline ordering of antimicrobial peptide–DNA complexes controls TLR9 activation

(2015) Nathan W. Schmidt et al.   NATURE MATERIALS

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

(2015) Spencer A. Freeman et al.   Nature Communications

Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial

(2015) Akhirunnesa Mily et al.   PLoS One

Fungicidal Mechanisms of Cathelicidins LL-37 and CATH-2 Revealed by Live-Cell Imaging

(2014) Soledad R. Ordonez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cathelicidin antimicrobial peptide LL-37 augments interferon-β expression and antiviral activity induced by double-stranded RNA in keratinocytes

(2014) T. Takiguchi et al.   BRITISH JOURNAL OF DERMATOLOGY

Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity

(2014) H. Brauner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

LL-37 Peptide Enhancement of Signal Transduction by Toll-like Receptor 3 Is Regulated by pH

(2014) Divyendu Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages

(2014) M. P. Gantier et al.   JOURNAL OF IMMUNOLOGY

Endogenous Intracellular Cathelicidin Enhances TLR9 Activation in Dendritic Cells and Macrophages

(2014) Yukinobu Nakagawa et al.   JOURNAL OF IMMUNOLOGY

Citrullination Alters Immunomodulatory Function of LL-37 Essential for Prevention of Endotoxin-Induced Sepsis

(2014) J. Koziel et al.   JOURNAL OF IMMUNOLOGY

Porcine Cathelicidins Efficiently Complex and Deliver Nucleic Acids to Plasmacytoid Dendritic Cells and Can Thereby Mediate Bacteria-Induced IFN-  Responses

(2014) A. Baumann et al.   JOURNAL OF IMMUNOLOGY

Novel Role of the Antimicrobial Peptide LL-37 in the Protection of Neutrophil Extracellular Traps against Degradation by Bacterial Nucleases

(2014) Ariane Neumann et al.   Journal of Innate Immunity

Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages

(2014) Min Wan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intervention on toll-like receptors in pancreatic cancer

(2014) Juan Vaz   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria

(2014) Abiola O. Olaitan et al.   Frontiers in Microbiology

Toll-like Receptors in Ovarian Cancer as Targets for Immunotherapies

(2014) Maria Muccioli et al.   Frontiers in Immunology

Roles of cathelicidin-related antimicrobial peptide in murine osteoclastogenesis

(2013) Kanji Horibe et al.   IMMUNOLOGY

Antimicrobial peptide LL-37 attenuates LTA induced inflammatory effect in macrophages

(2013) Yang Ruan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Human Antimicrobial Peptide LL-37, but Not the Mouse Ortholog, mCRAMP, Can Stimulate Signaling by Poly(I:C) through a FPRL1-dependent Pathway

(2013) Divyendu Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Cathelicidin-Related Antimicrobial Peptide in Inflammation and Mortality in a Mouse Model of Bacterial Meningitis

(2013) Julika Merres et al.   Journal of Innate Immunity

Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness

(2013) Caroline Hémont et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

Chicken Cathelicidins Display Antimicrobial Activity against Multiresistant Bacteria without Inducing Strong Resistance

(2013) Edwin J. A. Veldhuizen et al.   PLoS One

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

(2013) Silke M. Currie et al.   PLoS One

Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer

(2012) S. X. Ren et al.   CANCER RESEARCH

Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis

(2012) Yvonne Dombrowski et al.   EXPERIMENTAL DERMATOLOGY

Effect of antimicrobial peptides derived from human cathelicidin LL-37 on Entamoeba histolytica trophozoites

(2012) Rosa Rico-Mata et al.   EXPERIMENTAL PARASITOLOGY

Intrarectal administration of mCRAMP-encoding plasmid reverses exacerbated colitis in Cnlp−/− mice

(2012) E K K Tai et al.   GENE THERAPY

Antimicrobial peptides in the pathogenesis of psoriasis

(2012) Shin MORIZANE et al.   JOURNAL OF DERMATOLOGY

MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells

(2012) Atsuo Ochi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

(2012) S. Tripathi et al.   JOURNAL OF GENERAL VIROLOGY

Cathelicidin-Related Antimicrobial Peptide Is Required for Effective Lung Mucosal Immunity in Gram-Negative Bacterial Pneumonia

(2012) M. A. Kovach et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Signaling Pathways Mediating Chemokine Induction in Keratinocytes by Cathelicidin LL-37 and Flagellin

(2012) Anastasia Nijnik et al.   Journal of Innate Immunity

Cathelicidins: family of antimicrobial peptides. A review

(2012) Ewa M. Kościuczuk et al.   MOLECULAR BIOLOGY REPORTS

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Effective Adjunctive Therapy by an Innate Defense Regulatory Peptide in a Preclinical Model of Severe Malaria

(2012) A. H. Achtman et al.   Science Translational Medicine

A TLR4-interacting peptide inhibits lipopolysaccharide-stimulated inflammatory responses, migration and invasion of colon cancer SW480 cells

(2012) Madhusoodhanan Rakhesh et al.   OncoImmunology

Structure, Dynamics, and Antimicrobial and Immune Modulatory Activities of Human LL-23 and Its Single-Residue Variants Mutated on the Basis of Homologous Primate Cathelicidins

(2011) Guangshun Wang et al.   BIOCHEMISTRY

CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo

(2011) Ding Cao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Extracellular DNA in Biofilms

(2011) Lucio Montanaro et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Microbial Symbiosis with the Innate Immune Defense System of the Skin

(2011) Richard L. Gallo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands

(2011) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rosacea as a Disease of Cathelicidins and Skin Innate Immunity

(2011) Kenshi Yamasaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization

(2011) E. Margo Molhoek et al.   PEPTIDES

Evaluation of the Ability of LL-37 to Neutralise LPS In Vitro and Ex Vivo

(2011) Aaron Scott et al.   PLoS One

Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37

(2011) K. A. Sochacki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis

(2011) Srinivas Garlapati et al.   VACCINE

Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability

(2010) Fitzroy J. Byfield et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma

(2010) C. Brignole et al.   CANCER RESEARCH

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds

(2010) Gimano D. Amatngalim et al.   INFLAMMATION

Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents

(2010) E. Margo Molhoek et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

(2010) William K.K. Wu et al.   INTERNATIONAL JOURNAL OF CANCER

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons

(2010) Josh Gregorio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR3 and Rig-Like Receptor on Myeloid Dendritic Cells and Rig-Like Receptor on Human NK Cells Are Both Mandatory for Production of IFN-  in Response to Double-Stranded RNA

(2010) I. Perrot et al.   JOURNAL OF IMMUNOLOGY

LL-37 Directs Macrophage Differentiation toward Macrophages with a Proinflammatory Signature

(2010) A. M. van der Does et al.   JOURNAL OF IMMUNOLOGY

Chicken TLR21 Is an Innate CpG DNA Receptor Distinct from Mammalian TLR9

(2010) A. M. Keestra et al.   JOURNAL OF IMMUNOLOGY

Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses

(2009) E. Margo Molhoek et al.   BIOLOGICAL CHEMISTRY

Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation

(2009) D. Piccioli et al.   BLOOD

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils

(2009) Zhifang Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli

(2009) Niall C.J. Filewod et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Treatment with LL-37 Peptide Enhances Antitumor Effects Induced by CpG Oligodeoxynucleotides Against Ovarian Cancer

(2009) Chi-Mu Chuang et al.   HUMAN GENE THERAPY

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling

(2009) Fabiano Pinheiro da Silva et al.   IMMUNOLOGY AND CELL BIOLOGY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LL-37 Promotes Rapid Sensing of CpG Oligodeoxynucleotides by B Lymphocytes and Plasmacytoid Dendritic Cells

(2009) P. Hurtado et al.   JOURNAL OF IMMUNOLOGY

Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-  on APCs

(2009) A. Nijnik et al.   JOURNAL OF IMMUNOLOGY

Signaling Crosstalk during Sequential TLR4 and TLR9 Activation Amplifies the Inflammatory Response of Mouse Macrophages

(2009) D. De Nardo et al.   JOURNAL OF IMMUNOLOGY

Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS

(2009) Albert van Dijk et al.   MOLECULAR IMMUNOLOGY

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

(2009) Jason Kindrachuk et al.   VACCINE

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

Antimicrobial peptides and self-DNA in autoimmune skin inflammation

(2008) Michel Gilliet et al.   CURRENT OPINION IN IMMUNOLOGY

Host Defence Peptide LL-37 Induces IL-6 Expression in Human Bronchial Epithelial Cells by Activation of the NF-κB Signaling Pathway

(2008) Jelena Pistolic et al.   Journal of Innate Immunity

Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9

(2007) Stefan Bauer et al.   IMMUNOBIOLOGY