Synthetic Cationic Peptide IDR-1002 and Human Cathelicidin LL37 Modulate the Cell Innate Response but Differentially Impact PRRSV Replication in vitro

Porcine Reproductive and Respiratory Syndrome Virus Type 1.3 Lena Triggers Conventional Dendritic Cells 1 Activation and T Helper 1 Immune Response Without Infecting Dendritic Cells

(2018) Elise Bordet et al.   Frontiers in Immunology

Cathelicidins display conserved direct antiviral activity towards rhinovirus

(2017) Filipa Henderson Sousa et al.   PEPTIDES

In-vitro effect of human cathelicidin antimicrobial peptide LL-37 on dengue virus type 2

(2017) K. Alagarasu et al.   PEPTIDES

Antiviral Strategies against PRRSV Infection

(2017) Taofeng Du et al.   TRENDS IN MICROBIOLOGY

Preparation for emergence of an Eastern European porcine reproductive and respiratory syndrome virus (PRRSV) strain in Western Europe: Immunization with modified live virus vaccines or a field strain confers partial protection

(2017) P. Renson et al.   VETERINARY MICROBIOLOGY

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

(2016) Silke M. Currie et al.   JOURNAL OF IMMUNOLOGY

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System

(2016) Joan K. Lunney et al.   Annual Review of Animal Biosciences

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

Antimicrobial peptide LL-37 promotes antigen-specific immune responses in mice by enhancing Th17-skewed mucosal and systemic immunities

(2015) Sae-Hae Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Large Animal Models for Vaccine Development and Testing

(2015) V. Gerdts et al.   ILAR JOURNAL

Inhibitory activity and molecular mechanism of protegrin-1 against porcine reproductive and respiratory syndrome virus in vitro

(2014) Chunhe Guo et al.   ANTIVIRAL THERAPY

Antimicrobial and Immunomodulatory Activities of PR-39 Derived Peptides

(2014) Edwin J. A. Veldhuizen et al.   PLoS One

Host defense peptides: front-line immunomodulators

(2014) Sarah C. Mansour et al.   TRENDS IN IMMUNOLOGY

Antiviral potential of cathelicidins

(2013) Peter G Barlow et al.   Future Microbiology

The Human Antimicrobial Peptide LL-37, but Not the Mouse Ortholog, mCRAMP, Can Stimulate Signaling by Poly(I:C) through a FPRL1-dependent Pathway

(2013) Divyendu Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions

(2013) François Niyonsaba et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

(2013) Silke M. Currie et al.   PLoS One

In vitro and ex vivo analyses of co-infections with swine influenza and porcine reproductive and respiratory syndrome viruses

(2013) I. Dobrescu et al.   VETERINARY MICROBIOLOGY

Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections

(2012) Anne M. van der Does et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antimicrobial Peptides for Therapeutic Applications: A Review

(2012) Min-Duk Seo et al.   MOLECULES

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles

(2012) S. Garlapati et al.   VACCINE

Control of porcine reproductive and respiratory syndrome (PRRS) through genetic improvements in disease resistance and tolerance

(2012) Raymond R. R. Rowland et al.   Frontiers in Genetics

A comparison of anionic nanoparticles and microparticles as vaccine delivery systems

(2011) Janet Wendorf et al.   Human vaccines & immunotherapeutics

Antimicrobial Peptides Inhibit Polyinosinic-Polycytidylic Acid-Induced Immune Responses

(2011) M. Hasan et al.   JOURNAL OF IMMUNOLOGY

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

(2011) K. L. Brown et al.   JOURNAL OF IMMUNOLOGY

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

(2011) Yvonne Lai et al.   PLoS One

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis

(2011) Srinivas Garlapati et al.   VACCINE

Influence of maternal antibodies on active pertussis toxoid immunization of neonatal mice and piglets

(2011) Monika. Polewicz et al.   VACCINE

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations

(2011) Aleksandra Gracia et al.   VACCINE

Comparative Measurement of Cell-Mediated Immune Responses of Swine to the M and N Proteins of Porcine Reproductive and Respiratory Syndrome Virus

(2010) H. J. Jeong et al.   Clinical and Vaccine Immunology

The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

(2010) Sadek M. Alalwani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment

(2010) Anastasia Nijnik et al.   JOURNAL OF IMMUNOLOGY

A carpet-based mechanism for direct antimicrobial peptide activity against vaccinia virus membranes

(2010) R.E. Dean et al.   PEPTIDES

PCPP (poly[di(carboxylatophenoxy)-phosphazene]) microparticles co-encapsulating ovalbumin and CpG oligo-deoxynucleotides are potent enhancers of antigen specific Th1 immune responses in mice

(2010) Srinivas Garlapati et al.   VACCINE

Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets

(2010) Ding Cao et al.   VACCINE

Porcine reproductive and respiratory syndrome virus: An update on an emerging and re-emerging viral disease of swine

(2010) Joan K. Lunney et al.   VIRUS RESEARCH

The Potential of Polyphosphazenes for Delivery of Vaccine Antigens and Immunotherapeutic Agents

(2010) Nelson Eng et al.   Current Drug Delivery

Antimicrobial Host Defense Peptides in an Arteriviral Infection: Differential Peptide Expression and Virus Inactivation

(2009) Yongming Sang et al.   VIRAL IMMUNOLOGY

Porcine host defense peptides: Expanding repertoire and functions

(2008) Yongming Sang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Broad early immune response of porcine epithelial jejunal IPI-2I cells to Entamoeba histolytica

(2008) François Meurens et al.   MOLECULAR IMMUNOLOGY