Synergy effects of Polyinosinic-polycytidylic acid, CpG oligodeoxynucleotide, and cationic peptides to adjuvant HPV E7 epitope vaccine through preventive and therapeutic immunization in a TC-1 grafted mouse model

Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease

(2017) Selina Khan et al.   INTERNATIONAL JOURNAL OF CANCER

CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies

(2017) Nobutaka Hanagata   International Journal of Nanomedicine

Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development

(2017) Banu Bayyurt et al.   JOURNAL OF CONTROLLED RELEASE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer

(2017) Isobel S. Okoye et al.   Frontiers in Immunology

Hyaluronic Acid-Modified Cationic Lipid–PLGA Hybrid Nanoparticles as a Nanovaccine Induce Robust Humoral and Cellular Immune Responses

(2016) Lanxia Liu et al.   ACS Applied Materials & Interfaces

PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors

(2016) Roxanne Charlebois et al.   CANCER RESEARCH

Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+T cells

(2016) Shu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel rabies vaccine based-on toll-like receptor 3 (TLR3) agonist PIKA adjuvant exhibiting excellent safety and efficacy in animal studies

(2016) Yi Zhang et al.   VIROLOGY

CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1

(2016) Peng Yin et al.   Oncotarget

A novel vaccine for cervical cancer: quadrivalent human papillomavirus (types 6, 11, 16 and 18) recombinant vaccine (Gardasil®)

(2016) Vandana Govan   Therapeutics and Clinical Risk Management

Immunotherapy of HPV-associated cancer: DNA/plant-derived vaccines and new orthotopic mouse models

(2015) Aldo Venuti et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines

(2015) Liming Li et al.   Oncotarget

Melting Profiles May Affect Detection of Residual HPV L1 Gene DNA Fragments in Gardasil®

(2014) Sin Lee   CURRENT MEDICINAL CHEMISTRY

Designing and building the next generation of improved vaccine adjuvants

(2014) Luis A. Brito et al.   JOURNAL OF CONTROLLED RELEASE

CpG ODN Nanorings Induce IFN  from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

(2014) B. Gungor et al.   Science Translational Medicine

Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant

(2014) Karen Smith Korsholm et al.   VACCINE

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

(2014) Tae Jin Kim et al.   Nature Communications

Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

(2014) T. Bald et al.   Cancer Discovery

Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings

(2014) Bilgi Gungor et al.   OncoImmunology

Clinical impact of tumor-infiltrating CD45RO+ memory T cells on human gastric cancer

(2013) KOHEI WAKATSUKI et al.   ONCOLOGY REPORTS

Prognostic importance of tumour-infiltrating memory T cells in oesophageal squamous cell carcinoma

(2012) K. Enomoto et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Targeting TNF-  to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy

(2012) A. Calcinotto et al.   JOURNAL OF IMMUNOLOGY

Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice

(2012) S Domingos-Pereira et al.   Mucosal Immunology

Residual Baculovirus in Insect Cell-Derived Influenza Virus-Like Particle Preparations Enhances Immunogenicity

(2012) Irina Margine et al.   PLoS One

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin

(2011) Cristina Mansilla et al.   INTERNATIONAL JOURNAL OF CANCER

Cell-Mediated Immune Responses to Human Papillomavirus 16 E6 and E7 Antigens as Measured by Interferon Gamma Enzyme-Linked Immunospot in Women With Cleared or Persistent Human Papillomavirus Infection

(2010) Sepideh Farhat et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Induction of protective immunity against MHC class I-deficient, HPV16-associated tumours with peptide and dendritic cell-based vaccines

(2010) Reinis   INTERNATIONAL JOURNAL OF ONCOLOGY

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

(2010) Qing Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Adjuvating the adjuvant: Facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells

(2010) Michael C. Aichinger et al.   VACCINE

Treatment with LL-37 Peptide Enhances Antitumor Effects Induced by CpG Oligodeoxynucleotides Against Ovarian Cancer

(2009) Chi-Mu Chuang et al.   HUMAN GENE THERAPY

LL-37 Promotes Rapid Sensing of CpG Oligodeoxynucleotides by B Lymphocytes and Plasmacytoid Dendritic Cells

(2009) P. Hurtado et al.   JOURNAL OF IMMUNOLOGY

Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors

(2008) Szilvia Benkő et al.   BIOLOGICAL CHEMISTRY

Surgery followed by Persistence of High-Grade Squamous Intraepithelial Lesions Is Associated with the Induction of a Dysfunctional HPV16-Specific T-Cell Response

(2008) P. J. de Vos van Steenwijk et al.   CLINICAL CANCER RESEARCH

Human Papillomavirus Types 16 and 18 Vaccine (Recombinant, AS04 Adjuvanted, Adsorbed) [Cervarix???]

(2008) Susan J Keam et al.   DRUGS

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

(2008) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA