Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain

Prospective Virtual Screening in a Sparse Data Scenario: Design of Small-Molecule TLR2 Antagonists

(2014) Manuela S. Murgueitio et al.   ChemMedChem

Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models

(2014) T. Li et al.   HUMAN MOLECULAR GENETICS

Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR–TIR Interaction for Toll-Like Receptor Signaling Pathway

(2014) Tae-ho Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Inflammation-Responsive Antioxidant Nanoparticles Based on a Polymeric Prodrug of Vanillin

(2013) Jeongil Kwon et al.   BIOMACROMOLECULES

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli

(2013) G. A. Snyder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex

(2012) Kui Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Treatment With OPN-305, a Humanized Anti–Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs

(2012) Fatih Arslan et al.   Circulation-Cardiovascular Interventions

TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis

(2012) Angela Castoldi et al.   PLoS One

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Phosphatidylinositol 3-Kinase Activation Attenuates the TLR2-Mediated Macrophage Proinflammatory Cytokine Response to Francisella tularensis Live Vaccine Strain

(2010) E. A. Medina et al.   JOURNAL OF IMMUNOLOGY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Blocking TLR2 Activity Attenuates Pulmonary Metastases of Tumor

(2009) Hong-Zhen Yang et al.   PLoS One

Pseudomonas aeruginosa LPS or Flagellin Are Sufficient to Activate TLR-Dependent Signaling in Murine Alveolar Macrophages and Airway Epithelial Cells

(2009) Eloïse Raoust et al.   PLoS One

Heat Shock Co-Activates Interleukin-8 Transcription

(2008) Ishwar S. Singh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

(2008) Shijun Zhong et al.   JOURNAL OF MEDICINAL CHEMISTRY