MyD88 as a therapeutic target for inflammatory lung diseases

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD

(2017) Janice M. Leung et al.   RESPIROLOGY

Short-term Pharmacological Inhibition of MyD88 Homodimerization by a Novel Inhibitor Promotes Robust Allograft Tolerance in Mouse Cardiac and Skin Transplantation

(2017) Chao Li et al.   TRANSPLANTATION

Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells

(2017) Changwei Li et al.   Cell Death & Disease

TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice

(2016) Robert F. Foronjy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of myeloid differentiation factor 88(MyD88) by ST2825 provides neuroprotection after experimental traumatic brain injury in mice

(2016) Hua-Sheng Zhang et al.   BRAIN RESEARCH

IL-1R1-MyD88 axis elicits papain-induced lung inflammation

(2016) Rafiou Agoro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor

(2016) Ai Hua Zhang et al.   ORGANIC LETTERS

The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases

(2015) Jennifer Palomo et al.   CYTOKINE

IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome

(2015) Hanitriniaina Rabeony et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Therapeutic approaches to asthma–chronic obstructive pulmonary disease overlap syndromes

(2015) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions

(2015) Cem Gabay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer

(2015) Lin Xie et al.   JNCI-Journal of the National Cancer Institute

Targeting the interleukin pathway in the treatment of asthma

(2015) Kian Fan Chung   LANCET

Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

(2015) Mark A. Olson et al.   Scientific Reports

Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer

(2015) Lin Xie et al.   JNCI-Journal of the National Cancer Institute

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

(2013) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from theBrucellaProtein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

(2013) Greg A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 is crucial for the development of a protective CNS immune response to Toxoplasma gondii infection

(2013) Marbel Torres et al.   Journal of Neuroinflammation

Ligands and Receptors of the Interleukin-1 Family in Immunity and Disease

(2013) Cecilia Garlanda et al.   Frontiers in Immunology

Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets

(2012) Thomas Ve et al.   CURRENT DRUG TARGETS

Dendritic Cells in Pathogenesis of COPD

(2012) Masoumeh Ezzati Givi et al.   CURRENT PHARMACEUTICAL DESIGN

Bacterial and fungal markers in tobacco smoke

(2012) B. Szponar et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microbiological components in mainstream and sidestream cigarette smoke

(2012) Lennart Larsson et al.   Tobacco Induced Diseases

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant

(2011) A.-G. Besnard et al.   ALLERGY

The TIR/BB-loop mimetic AS-1 prevents cardiac hypertrophy by inhibiting IL-1R-mediated MyD88-dependent signaling

(2011) Yun Zhu et al.   BASIC RESEARCH IN CARDIOLOGY

Inhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary disease

(2011) Magnus Korsgren et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

The T-Helper Cell Type 1 Immune Response to Gram-Negative Bacterial Infections Is Impaired in COPD

(2010) Jürgen Knobloch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-Term Cigarette Smoke Exposure in a Mouse Model of Ciliated Epithelial Cell Function

(2009) Samantha M. Simet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury

(2009) Z. Cao et al.   CARDIOVASCULAR RESEARCH

IL-1R1/MyD88 Signaling Is Critical for Elastase-Induced Lung Inflammation and Emphysema

(2009) I. Couillin et al.   JOURNAL OF IMMUNOLOGY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

(2008) Sanjay Sethi et al.   NEW ENGLAND JOURNAL OF MEDICINE