Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice

Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins

(2020) Yuchen Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adolescent Exploratory Strategies and Behavioral Types in the Multivariate Concentric Square FieldTM Test

(2019) Stina Lundberg et al.   Frontiers in Behavioral Neuroscience

Effect of epigallocatechin gallate on the body composition and lipid profile of down syndrome individuals: Implications for clinical management

(2019) Laura Xicota et al.   CLINICAL NUTRITION

Usage of and attitudes about green tea extract and Epigallocathechin-3-gallate (EGCG) as a therapy in individuals with Down syndrome

(2019) Rachel Long et al.   COMPLEMENTARY THERAPIES IN MEDICINE

The safety of green tea and green tea extract consumption in adults – Results of a systematic review

(2018) Jiang Hu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase

(2017) Livia Misuri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes

(2017) Megan Stringer et al.   PHYSIOLOGY & BEHAVIOR

Bioactive nutrients - Time for tolerable upper intake levels to address safety

(2017) Allison A. Yates et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Safety assessment of green tea based beverages and dried green tea extracts as nutritional supplements

(2017) Wolfgang Dekant et al.   TOXICOLOGY LETTERS

The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice

(2017) Marco Cascella et al.   Infectious Agents and Cancer

Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits

(2017) Megan Stringer et al.   Molecular Genetics & Genomic Medicine

Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

(2017) Xiaomin Yin et al.   Scientific Reports

Protective role of epigallocatechin-3-gallate in health and disease: A perspective

(2016) Animesh Chowdhury et al.   BIOMEDICINE & PHARMACOTHERAPY

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

Differential effects of Epigallocatechin-3-gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model

(2016) Irushi Abeysekera et al.   MOLECULAR NUTRITION & FOOD RESEARCH

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

(2016) Arnaud Duchon et al.   Frontiers in Behavioral Neuroscience

Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomicDyrk1a

(2015) Joshua D. Blazek et al.   HUMAN MOLECULAR GENETICS

Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model

(2015) Megan Stringer et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

(2015) Benoit Souchet et al.   Frontiers in Behavioral Neuroscience

Structural and Mechanical Improvements to Bone Are Strain Dependent with Axial Compression of the Tibia in Female C57BL/6 Mice

(2015) Alycia G. Berman et al.   PLoS One

Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes

(2014) M. D. Hall et al.   CANCER RESEARCH

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene Dyrk1a

(2014) A. Thomazeau et al.   JOURNAL OF NEUROSCIENCE

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

(2014) Benoit Souchet et al.   NEUROBIOLOGY OF DISEASE

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome

(2014) Joongkyu Park et al.   Experimental Neurobiology

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A

(2013) Meritxell Pons-Espinal et al.   NEUROBIOLOGY OF DISEASE

Green tea polyphenols in drug discovery: a success or failure?

(2011) Thomas J Smith   Expert Opinion on Drug Discovery

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

The Multivariate Concentric Square Field Test Reveals Behavioral Profiles of Risk Taking, Exploration, and Cognitive Impairment in Mice Subjected to Traumatic Brain Injury

(2010) Sara Ekmark-Lewén et al.   JOURNAL OF NEUROTRAUMA

Fourteen-Week Toxicity Study of Green Tea Extract in Rats and Mice

(2010) Po C. Chan et al.   TOXICOLOGIC PATHOLOGY

Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6brd1

(2009) Alberto C.S. Costa et al.   BEHAVIOURAL BRAIN RESEARCH

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development

(2008) Barbara Hämmerle et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

Inverse association of high-fat diet preference and anxiety-like behavior: a putative role for urocortin 2

(2008) J. Alsiö et al.   GENES BRAIN AND BEHAVIOR

Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

(2008) Glòria Arqué et al.   PLoS One