Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomicDyrk1a

Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner

(2015) Joshua D. Blazek et al.   MECHANISMS OF DEVELOPMENT

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

(2014) Susana García-Cerro et al.   PLoS One

New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome

(2014) Joongkyu Park et al.   Experimental Neurobiology

Epigallocatechin-3-Gallate Inhibits IGF-I-Stimulated Lung Cancer Angiogenesis through Downregulation of HIF-1a and VEGF Expression

(2013) Xiangyong Li et al.   Journal of Nutrigenetics and Nutrigenomics

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A

(2013) Meritxell Pons-Espinal et al.   NEUROBIOLOGY OF DISEASE

Expression of trisomic proteins in Down syndrome model systems

(2012) Claire Spellman et al.   GENE

Polyphenols suppress hydrogen peroxide-induced oxidative stress in human bone-marrow derived mesenchymal stem cells

(2012) Haruyo Yagi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dyrk1A, a Serine/Threonine Kinase, is Involved in ERK and Akt Activation in the Brain of Hyperhomocysteinemic Mice

(2012) Sabiha Abekhoukh et al.   MOLECULAR NEUROBIOLOGY

Low bone turnover and low bone density in a cohort of adults with Down syndrome

(2012) K. D. McKelvey et al.   OSTEOPOROSIS INTERNATIONAL

Low Bone Turnover and Low BMD in Down Syndrome: Effect of Intermittent PTH Treatment

(2012) Tristan W. Fowler et al.   PLoS One

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

(2011) B. Hammerle et al.   DEVELOPMENT

Akt Induces Osteoclast Differentiation through Regulating the GSK3 /NFATc1 Signaling Cascade

(2011) J. B. Moon et al.   JOURNAL OF IMMUNOLOGY

Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

(2011) Yoshiomi Oka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity

(2011) Yongzheng He et al.   PLoS One

Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

(2010) Samantha E. Parker et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice

(2010) Joshua D. Blazek et al.   BONE

Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity

(2010) Chrisovalantis Papadopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

(2010) Lina Chakrabarti et al.   NATURE NEUROSCIENCE

Complex contributions ofEts2to craniofacial and thymus phenotypes of trisomic “Down syndrome” mice

(2009) Cheryl A. Hill et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

P2X7 Nucleotide Receptor Plays an Important Role in Callus Remodeling During Fracture Repair

(2009) Jiliang Li et al.   CALCIFIED TISSUE INTERNATIONAL

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

(2009) Youngkyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS