Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene Dyrk1a

(2014) A. Thomazeau et al.   JOURNAL OF NEUROSCIENCE

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

(2014) Benoit Souchet et al.   NEUROBIOLOGY OF DISEASE

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

(2014) Susana García-Cerro et al.   PLoS One

Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice

(2013) Asma Tlili et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Memory coding in individuals with Down syndrome

(2013) Silvia Lanfranchi et al.   CHILD NEUROPSYCHOLOGY

Reducing GABAA  5 Receptor-Mediated Inhibition Rescues Functional and Neuromorphological Deficits in a Mouse Model of Down Syndrome

(2013) C. Martinez-Cue et al.   JOURNAL OF NEUROSCIENCE

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Alterations to Dendritic Spine Morphology, but Not Dendrite Patterning, of Cortical Projection Neurons in Tc1 and Ts1Rhr Mouse Models of Down Syndrome

(2013) Matilda A. Haas et al.   PLoS One

Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABAB Receptor Antagonists

(2012) A. M. Kleschevnikov et al.   JOURNAL OF NEUROSCIENCE

DYRK1A: A master regulatory protein controlling brain growth

(2012) Fayçal Guedj et al.   NEUROBIOLOGY OF DISEASE

Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly

(2011) BWM van Bon et al.   CLINICAL GENETICS

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

(2011) J Braudeau et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer

(2011) Mehrdad Faizi et al.   NEUROBIOLOGY OF DISEASE

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

(2009) N. P. Belichenko et al.   JOURNAL OF NEUROSCIENCE

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One