Article
Multidisciplinary Sciences
John M. Starbuck, Sergi Llambrich, Ruben Gonzalez, Julia Albaiges, Anna Sarle, Jens Wouters, Alejandro Gonzalez, Xavier Sevillano, James Sharpe, Rafael De La Torre, Mara Dierssen, Greetje Vande Velde, Neus Martinez-Abadias
Summary: The study found that in the DS mouse model, low doses of GTE-EGCG were beneficial for improving facial skeletal morphology, while early supplementation of EGCG in DS children was associated with reduced facial dysmorphology. However, high doses of GTE-EGCG usage led to increased facial dysmorphology, indicating dose-dependent effects of GTE-EGCG on modulating facial development.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Multidisciplinary Sciences
Raza Jamal, Jonathan LaCombe, Roshni Patel, Matthew Blackwell, Jared R. Thomas, Kourtney Sloan, Joseph M. Wallace, Randall J. Roper
Summary: This study found that high doses of EGCG treatment in Ts65Dn mice may worsen skeletal structural deficits, indicating the importance of monitoring skeletal phenotypes when administering high doses of EGCG therapeutically.
Article
Chemistry, Applied
Jianyong Zhang, Hongchun Cui, Jiahuan Qiu, Xiaoqing Wang, Yixin Zhong, Caiping Yao, Lanying Yao, Qunxiong Zheng, ChunHua Xiong
Summary: This study aimed to improve the stability and bioavailability of EGCG in aqueous solutions and in vivo by preparing EGCG glycosylated arachin nanoparticles and EGCG glycosylated casein nanoparticles. The results showed that the DPPH scavenging activity of the nanoparticles was stable within temperature range of 25-70 degrees Celsius. EGCG enhanced the crosslinking effect of molecular particles in the glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid.
Article
Agriculture, Multidisciplinary
Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, Xiaoxiao Wang, Xiuli Li, Jinsong Zhang
Summary: The study found that L-theanine in tea can inhibit the oxidation of tea catechins by chelating copper, thereby protecting the liver from damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nan Zhang, Chaoren Yan, Changji Yin, Xiaoling Hu, Ping Guan, Yuan Cheng
Summary: Epigallocatechin-3gallate (EGCG) extracted from green tea is a promising small-molecule drug candidate for Alzheimer's disease. This study used molecular dynamics simulations and experiments to investigate the mechanism of EGCG-induced remodeling of Aβ fibrils.
Article
Cell Biology
Honghui Zhang, Wei Su, Rusong Zhao, Mei Li, Shigang Zhao, Zi-Jiang Chen, Han Zhao
Summary: This study delves into the precise impact and underlying mechanisms of EGCG on aged oocytes. Both in vitro and in vivo experiments demonstrate EGCG's capacity to enhance the quality of aged oocytes. In vitro application of EGCG yields remarkable improvements, including heightened rates of first polar body extrusion, refined spindle morphology, enhanced mitochondrial function, and reduced oxidative stress. Besides, EGCG may enhance Arf6 expression through direct interaction in aged oocytes, consequently promoting the assembly of spindle-associated F-actin and mitigating the aneuploidy induced by the disruption of spindle F-actin. In addition, these positive outcomes are corroborated by enhanced fertility observed in aged mice, providing a therapeutic intervention to address fertility challenges associated with advanced age.
CELL PROLIFERATION
(2023)
Article
Plant Sciences
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu
Summary: The combination of EGCG with Vc and glycerol could effectively increase its stability and uric acid-lowering activity, which sheds light on the development and application of EGCG in the fields of food and medicine.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Tomonori Unno, Yoshiharu Araki, Shun Inagaki, Makoto Kobayashi, Masaki Ichitani, Takanobu Takihara, Hitoshi Kinugasa
Summary: Dietary fructooligosaccharides (FOS) were found to increase the plasma concentration of EGCG in rats by preventing its auto-oxidation. Treatment with FOS resulted in a dose-dependent increase in cecal lactate levels and alterations in the abundance of Lactobacillus and Collinsella. Consequently, FOS contributed to the protection of EGCG from auto-oxidation and allowed it to be absorbed into the blood circulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Immunology
Yingjie Wang, Shanqiu Jian, Wen Li, Ling Zhao, Gang Ye, Fei Shi, Lixia Li, Yuanfeng Zou, Xu Song, Xinghong Zhao, Zhongqiong Yin, Yinglun Li, Huaqiao Tang
Summary: This study evaluated the protective effect of epigallocatechin gallate (EGCG) on liver damage secondary to P. aeruginosa infection. The results showed that EGCG reduced liver function markers, improved histopathological changes, reduced oxidative stress and inhibited inflammation response. EGCG exerted its liver protective effect through regulation of multiple signaling pathways, providing a new therapeutic strategy for P. aeruginosa infection-related liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Engineering, Environmental
Yuan Cheng, Xin Li, Ming-Ya Fang, Qing-Jing Ye, Zhi-Miao Li, Golam Jalal Ahammed
Summary: The application of EECCG alleviated the adverse effects of cadmium stress in tomato plants by reducing oxidative stress and promoting the expression of RBOH1 gene. These findings contribute to our understanding of the stress resistance properties of EGCG in plants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Oncology
Chunguang Wang, Meiling Bai, Zhiguang Sun, Nan Yao, Aiting Zhang, Shengyu Guo, Zatollah Asemi
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that affect gene expression and are inappropriately expressed in various cancers. Recent research shows that phytochemicals like EGCG can modulate miRNAs and have potential anticancer effects. Targeting specific miRNAs with EGCG can regulate cancer-related processes and improve current cancer treatments.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Alycia G. Berman, John G. Damrath, Jennifer Hatch, Alexis N. Pulliam, Katherine M. Powell, Madicyn Hinton, Joseph M. Wallace
Summary: The study found that the combination treatment of Raloxifene and targeted tibial loading can enhance bone architecture and mechanical integrity, leading to greater improvements than either treatment individually.
CONNECTIVE TISSUE RESEARCH
(2022)
Article
Endocrinology & Metabolism
Samantha P. Tippen, Corinne E. Metzger, Elizabeth A. Swallow, Spencer A. Sacks, Joseph M. Wallace, Matthew R. Allen
Summary: The study aimed to investigate the interaction between chronic kidney disease (CKD) and aging on bone structure and mechanical properties. The results showed that aging mice with CKD had significantly higher cortical porosity than young mice, and both structural and mechanical properties were poorer in aging mice.
Article
Multidisciplinary Sciences
Raza Jamal, Jonathan LaCombe, Roshni Patel, Matthew Blackwell, Jared R. Thomas, Kourtney Sloan, Joseph M. Wallace, Randall J. Roper
Summary: This study found that high doses of EGCG treatment in Ts65Dn mice may worsen skeletal structural deficits, indicating the importance of monitoring skeletal phenotypes when administering high doses of EGCG therapeutically.
Article
Endocrinology & Metabolism
Alyson L. Essex, Joshua R. Huot, Padmini Deosthale, Alison Wagner, Jorge Figueras, Azaria Davis, John Damrath, Fabrizio Pin, Joseph Wallace, Andrea Bonetto, Lilian Plotkin
Summary: This study reveals that the Trem2 variant associated with Alzheimer's disease risk may independently affect bone and skeletal muscle loss, regardless of central nervous system defects. These findings suggest a potential link between Trem2 signaling alterations and skeletal health.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
John G. Damrath, Sharon M. Moe, Joseph M. Wallace
Summary: Chronic kidney disease affects bone quality, and treatment with calcimimetics improves tissue-level bone material properties to prevent bone deterioration.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Editorial Material
Genetics & Heredity
Randall J. Roper, Charles R. Goodlett
Summary: Animal models of Down syndrome are crucial for studying the genetic, cellular, and molecular factors contributing to traits associated with trisomy 21. Recent advancements in genetic enhancements, such as the TcHSA21rat model, have the potential to revolutionize our understanding of and potential therapies for Down syndrome.
TRENDS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
John G. Damrath, Corinne E. Metzger, Matthew R. Allen, Joseph M. Wallace
Summary: Diabetes and chronic kidney disease can have detrimental effects on bone health, especially when both conditions are present. They can lead to decreased bone turnover, decreased trabecular bone volume, and lowered bone density. The combined effects of both diseases are even more severe.
Article
Engineering, Biomedical
Amin Joukar, Amy Creecy, Sonali Karnik, Hessam Noori-Dokht, Stephen B. Trippel, Joseph M. Wallace, Diane R. Wagner
Summary: The main objective of this study was to assess the relationship between the wear resistance of healthy articular cartilage and its biochemical composition and viscoelastic material properties. The findings suggest that stiffer cartilage with higher glycosaminoglycans, collagen, and water content has a higher wear resistance. Enzymatic collagen crosslinks also enhance the wear resistance of the collagen network.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Endocrinology & Metabolism
Andrea Jacobson, Carli A. Tastad, Amy Creecy, Joseph M. Wallace
Summary: Thermoneutral housing and Raloxifene treatment have the potential to improve bone properties. Housing mice within a specific temperature range improves bone quality, while Raloxifene treatment enhances bone strength and geometry. Considering the impact of temperature on mice is important for longer pre-clinical trials to improve the accuracy of the models.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Rachel K. Surowiec, Matthew R. Allen, Joseph M. Wallace
Summary: Water in bone plays an important role in its mechanical properties and tissue quality. Different compartments of water in bone have different effects. Current research focuses on understanding the changes in bone water under various conditions and improving mechanical properties through therapeutic targeting of water.
Article
Endocrinology & Metabolism
Elizabeth A. Swallow, Corinne E. Metzger, Neal X. Chen, Joseph M. Wallace, Samantha P. Tippen, Rachel Kohler, Sharon M. Moe, Matthew R. Allen
Summary: This study assessed the impact of different bisphosphonates and dosing regimens on cortical microstructure and bone mechanical properties in animal models of chronic kidney disease (CKD). The results showed that a single dose of zoledronate led to higher cortical porosity, while more frequent dosing of bisphosphonates had minimal effect on cortical bone microstructure.
Meeting Abstract
Endocrinology & Metabolism
John Damrath, Sharon Moe, Joseph Wallace
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Rachel K. Surowiec, Ratan K. Rai, John G. Damrath, Matthew R. Allen, Joseph M. Wallace
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Elizabeth A. Swallow, Corinne E. Metzger, Samantha P. Tippen, Rachel Kohler, Joseph M. Wallace, Matthew R. Allen
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
John G. Damrath, Neal X. Chen, Corinne E. Metzger, Shruthi Srinivasan, Kalisha O'Neill, Annabel Biruete, Keith G. Avin, Joseph M. Wallace, Matthew R. Allen, Sharon M. Moe
Summary: Chronic kidney disease-mineral and bone disorder (CKD-MBD) increases cardiovascular calcification and skeletal fragility. Treatments aimed at reducing oxidative stress and parathyroid hormone (PTH) levels can help prevent these complications.