Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders

Genetic Variants in the Promoter Region of the ALOX5AP Gene and Susceptibility of Ischemic Stroke

(2017) Ruijun Ji et al.   CEREBROVASCULAR DISEASES

Role of Cyclooxygenase-2 and 5-Lipoxygenase Polymorphisms in Alzheimer's Disease in a Population from Northern Italy: Implication for Pharmacogenomics

(2017) Florinda Listì et al.   JOURNAL OF ALZHEIMERS DISEASE

The natural dual cyclooxygenase and 5-lipoxygenase inhibitor flavocoxid is protective in EAE through effects on Th1/Th17 differentiation and macrophage/microglia activation

(2016) Weimin Kong et al.   BRAIN BEHAVIOR AND IMMUNITY

Montelukast reduces seizures in pentylenetetrazol-kindled mice

(2016) J. Fleck et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Fatty acids, eicosanoids and PPAR gamma

(2016) Rachel Marion-Letellier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index

(2016) Omar Šerý et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

(2016) Marta Fumagalli et al.   NEUROPHARMACOLOGY

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid

(2015) Satoshi Itadani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CysLT 2 receptor mediates lipopolysaccharide-induced microglial inflammation and consequent neurotoxicity in vitro

(2015) Lu Chen et al.   BRAIN RESEARCH

The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia

(2015) Bruno Silva et al.   CURRENT NEUROVASCULAR RESEARCH

Knockdown of hippocampal cysteinyl leukotriene receptor 1 prevents depressive behavior and neuroinflammation induced by chronic mild stress in mice

(2015) Xu-Ben Yu et al.   PSYCHOPHARMACOLOGY

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

(2015) Julia Marschallinger et al.   Nature Communications

Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors

(2015) Katie J. Herbst-Robinson et al.   Scientific Reports

Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells

(2015) Hideaki Shirasaki et al.   ALLERGOLOGY INTERNATIONAL

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits

(2014) Chelsea E. Corser-Jensen et al.   EXPERIMENTAL NEUROLOGY

Leukotrienes induce the migration of Th17 cells

(2014) Wonyong Lee et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression of dual Nucleotides/Cysteinyl-Leukotrienes Receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction

(2014) Simona Cosentino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

P2Y6 Receptors Require an Intact Cysteinyl Leukotriene Synthetic and Signaling System to Induce Survival and Activation of Mast Cells

(2014) Y. Jiang et al.   JOURNAL OF IMMUNOLOGY

Effect of Licofelone—A Dual COX/5-LOX Inhibitor in Intracerebroventricular Streptozotocin-Induced Behavioral and Biochemical Abnormalities in Rats

(2014) Ashok Kumar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist Protects Against Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rats

(2014) M. A. Saad et al.   NEUROCHEMICAL RESEARCH

Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice

(2014) Jin'e Lai et al.   NEUROPHARMACOLOGY

Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood–brain barrier dysfunction

(2014) Q.F. Lenz et al.   NEUROSCIENCE

Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4+ T cells across an in vitro blood–brain barrier model

(2014) Jonathan Bertin et al.   VIROLOGY

Cysteinyl leukotrienes and their receptors: Bridging inflammation and colorectal cancer

(2014) Sayeh Savari   WORLD JOURNAL OF GASTROENTEROLOGY

Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro

(2013) Shu-ying Yu et al.   ACTA PHARMACOLOGICA SINICA

Antileukotriene Agents for the Treatment of Lung Disease

(2013) Jacob P. Scott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Multiple-Site Activation of the Cysteinyl Leukotriene Receptor 2 Is Required for Exacerbation of Ischemia/Reperfusion Injury

(2013) Nathan C. Ni et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit, Synaptic Dysfunction, and Neuropathology in a Mouse Model of Alzheimer’s Disease

(2013) Phillip F. Giannopoulos et al.   BIOLOGICAL PSYCHIATRY

Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase

(2013) Yi-Ping Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protective effect of pranlukast on Aβ 1–42-induced cognitive deficits associated with downregulation of cysteinyl leukotriene receptor 1

(2013) Su-Su Tang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4Ligand

(2013) Yoshihide Kanaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Leukotriene C4 Activates Mouse Platelets in Plasma Exclusively through the Type 2 Cysteinyl Leukotriene Receptor

(2013) H. E. Cummings et al.   JOURNAL OF IMMUNOLOGY

Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons

(2013) Xiao Yun Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Protection of dopaminergic neurons by 5-lipoxygenase inhibitor

(2013) Kai-Hsiang Kang et al.   NEUROPHARMACOLOGY

Characterisation of P2Y12 Receptor Responsiveness to Cysteinyl Leukotrienes

(2013) Holly R. Foster et al.   PLoS One

Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist

(2013) S. Hennen et al.   Science Signaling

FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo 

(2013) J Chu et al.   Translational Psychiatry

Disruption of the alox5ap gene ameliorates focal ischemic stroke: possible consequence of impaired leukotriene biosynthesis

(2012) Jakob O Ström et al.   BMC NEUROSCIENCE

Open study of pranlukast add-on therapy in intractable partial epilepsy

(2012) Yukitoshi Takahashi et al.   BRAIN & DEVELOPMENT

Intracerebroventricular injection of HAMI 3379, a selective cysteinyl leukotriene receptor 2 antagonist, protects against acute brain injury after focal cerebral ischemia in rats

(2012) Qiao-Juan Shi et al.   BRAIN RESEARCH

Cysteinyl leukotriene receptors, old and new; implications for asthma

(2012) T. M. Laidlaw et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease

(2012) Erik Ingelsson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1

(2012) Xue-Qin Huang et al.   Journal of Neuroinflammation

Leukotriene D4 induces cognitive impairment through enhancement of CysLT1R-mediated amyloid-β generation in mice

(2012) Su-Su Tang et al.   NEUROPHARMACOLOGY

Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability

(2012) V.P. Chou et al.   NEUROSCIENCE

Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats

(2012) Anil Kumar et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Genetic variation in members of the leukotrienes biosynthesis pathway confers risk of ischemic stroke in Eastern Han Chinese

(2012) Gannan Wang et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain

(2012) N. Kyritsis et al.   SCIENCE

Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice

(2012) Wen-Zhen Shi et al.   Neuroscience Bulletin

Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model

(2011) Jin Chu et al.   AMERICAN JOURNAL OF PATHOLOGY

Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

(2011) Mary-Clare Cathcart et al.   CANCER AND METASTASIS REVIEWS

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Cytosolic Phospholipase A2  Blockade Abrogates Disease during the Tissue-Damage Effector Phase of Experimental Autoimmune Encephalomyelitis by Its Action on APCs

(2011) P. Thakker et al.   JOURNAL OF IMMUNOLOGY

Antiasthmatic Drugs Targeting the Cysteinyl Leukotriene Receptor 1 Alleviate Central Nervous System Inflammatory Cell Infiltration and Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2011) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Montelukast, a cysteinyl leukotriene receptor-1 antagonist, attenuates chronic brain injury after focal cerebral ischaemia in mice and rats

(2011) Rui Zhao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cysteinyl leukotriene receptor 2 is spatiotemporally involved in neuron injury, astrocytosis and microgliosis after focal cerebral ischemia in rats

(2011) C.Z. Zhao et al.   NEUROSCIENCE

The new P2Y-like receptor G protein-coupled receptor 17 mediates acute neuronal injury and late microgliosis after focal cerebral ischemia in rats

(2011) B. Zhao et al.   NEUROSCIENCE

Involvement of 5-Lipoxygenase in the Corticosteroid-Dependent Amyloid Beta Formation: In Vitro and In Vivo Evidence

(2011) Simone Puccio et al.   PLoS One

Differential Inhibitory Effects of CysLT1 Receptor Antagonists on P2Y6 Receptor-Mediated Signaling and Ion Transport in Human Bronchial Epithelia

(2011) Wendy Ka-hoi Lau et al.   PLoS One

Modulation of leukotriene D4 attenuates the development of seizures in mice

(2011) Ashish K. Rehni et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage

(2011) K. Yoshikawa et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo

(2010) Jin Chu et al.   ANNALS OF NEUROLOGY

An update on the role of leukotrienes in asthma

(2010) Teal S Hallstrand et al.   Current Opinion in Allergy and Clinical Immunology

Arachidonic Acid Metabolism Regulates Escherichia coli Penetration of the Blood-Brain Barrier

(2010) L. Zhu et al.   INFECTION AND IMMUNITY

A tagging SNP in ALOX5AP and risk of stroke: a haplotype-based analysis among eastern Chinese Han population

(2010) Hao Sun et al.   MOLECULAR BIOLOGY REPORTS

Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats

(2010) H. Kalonia et al.   NEUROSCIENCE

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis

(2009) Athena Kalyvas et al.   BRAIN

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12receptor

(2009) Sailaja Paruchuri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Injury-Related Production of Cysteinyl Leukotrienes Contributes to Brain Damage following Experimental Traumatic Brain Injury

(2009) Santiago Farias et al.   JOURNAL OF NEUROTRAUMA

Leukotriene D4 Stimulates the Migration but Not Proliferation of Endothelial Cells Mediated by the Cysteinyl Leukotriene CysLT1 Receptor via the Extracellular Signal-Regulated Kinase Pathway

(2009) Yu-Mei Yuan et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9

(2009) Xian-Kun Tu et al.   NEUROLOGICAL RESEARCH

GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4

(2009) Akiko Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship Between Cysteinyl-Leukotriene-1 Receptor and Human Transitional Cell Carcinoma in Bladder

(2009) Masahide Matsuyama et al.   UROLOGY

Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission

(2008) Ariel T Arthur et al.   BMC Medical Genetics

Leukotriene E4Activates Peroxisome Proliferator-activated Receptor γ and Induces Prostaglandin D2Generation by Human Mast Cells

(2008) Sailaja Paruchuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

(2008) Milos D. Ikonomovic et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY