Article
Medicine, Research & Experimental
Bochra Tourki, Laurence M. Black, Vasundhara Kain, Ganesh Halade
Summary: The persistent increase in 12/15 lipoxygenase enzyme activity is associated with uncontrolled inflammation, which can lead to organ dysfunction. The use of the ML351 antagonist to inhibit lipoxygenases can suppress inflammation initiation but may also disrupt the acute immune response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Verena Krauth, Ferdinando Bruno, Simona Pace, Paul M. Jordan, Veronika Temml, Maria Preziosa Romano, Haroon Khan, Daniela Schuster, Antonietta Rossi, Rosanna Filosa, Oliver Werz
Summary: 5-Lipoxygenase (LO) is a key enzyme in the formation of pro-inflammatory leukotrienes (LT) that are important mediators in allergic reactions and inflammatory disorders. In this study, modifications were made to catechol derivatives to increase their effectiveness as selective 5-LO inhibitors. Two compounds, 3,4-dihydroxy-3 '-phenoxybiphenyl (6b) and 2-(3,4-dihydroxyphenyl)benzo[b]thiophene (6d), showed potent inhibition of human 5-LO in both cell-free and cell-based assays. Furthermore, these compounds were effective in inhibiting 5-LO in human blood and in a murine peritonitis model. These novel catechol derivatives have high selectivity and effectiveness as inhibitors of 5-LO under pathophysiological conditions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Ferdinando Bruno, Verena Krauth, Seyed Mohamed Nabavi, Veronika Temml, Florinda Fratianni, Giuseppe Spaziano, Filomena Nazzaro, Fiorita Roviezzo, Jianbo Xiao, Haroon Kahn, Maria Preziosa Romano, Bruno D'Agostino, Oliver Werz, Rosanna Filosa
Summary: Oxidative stress and inflammation coexist in many multifactorial diseases, and the discovery of antioxidants is an appealing approach to target multiple therapeutic pathways in the arachidonic acid cascade.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Joyce Lim, Allan Davies, Stephen Brienesse, Nishani S. Mabotuwana, Andrew Boyle
Summary: This systematic review investigates the association between leukocyte response and outcomes in patients with STEMI. The findings suggest that leukocyte count is associated with the occurrence of MACE within 30 days and 1 year. However, the high heterogeneity among studies limits the generalizability of these findings and further research is needed.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Aoife B. Kilgallen, Frederieke van den Akker, Dries A. M. Feyen, Sandra Crnko, Christian J. B. Snijders Blok, Hendrik Gremmels, Bastiaan C. du Pre, Robin Reijers, Pieter A. Doevendans, Saskia C. A. de Jager, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Linda W. van Laake
Summary: Circadian rhythms play a crucial role in the hyperacute immune response after a myocardial infarction (MI). The levels of immune cells and cardiac damage vary throughout the day, indicating the circadian influence on the immune response. These findings align with the clinical observation that patients who experience an MI early in the morning have worse outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Yusra Zaidi, Eslie G. Aguilar, Miguel Troncoso, Daria Ilatovskaya, Kristine Y. DeLeon-Pennell
Summary: Myocardial infarction (MI) results in pathological changes in the left ventricle's extracellular matrix, which can cause cardiac stiffness and affect systolic and diastolic function. The signals released from necrotic tissue initiate an immune cascade and lead to inflammatory response and reparative fibrosis, with immune cells playing key roles in balancing pro-fibrotic and anti-fibrotic responses. This review explores how molecular signals between fibroblasts and immune cells regulate fibrosis post-MI, and discusses emerging pharmacological targets and therapies for inflammation and cardiac fibrosis associated with MI.
CELLULAR SIGNALLING
(2021)
Review
Biochemistry & Molecular Biology
Ming-Ju Tsai, Wei-An Chang, Cheng-Hao Chuang, Kuan-Li Wu, Chih-Hung Cheng, Chau-Chyun Sheu, Ya-Ling Hsu, Jen-Yu Hung
Summary: Cancer is still a leading cause of death worldwide. Changes in the tumor microenvironment, especially dysregulated immunity, may contribute to carcinogenesis and cancer progression. The cysteinyl leukotriene pathway plays an important role in cancer, particularly through the CysLT(1) receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ha Young Jang, In-Wha Kim, Jung Mi Oh
Summary: The study found that the use of LTRAs was associated with a decreased risk of cancer, especially when used in high dose and for a longer duration. The results could be utilized for developing new chemo-preventive regimens or designing feasible RCTs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Neeraj Dholia, Gurupreet S. Sethi, Amarjit S. Naura, Umesh C. S. Yadav
Summary: The study found that LTD4 can induce inflammatory response in human airway epithelial cells by activating the NALP3 inflammasome, and further promote airway epithelial cells' remodeling through the TGF-beta/smad2/3-mediated pathway. Additionally, obese mice challenged with OVA showed asthma-like lung inflammation and remodeling phenotypes.
INFLAMMATION RESEARCH
(2021)
Article
Cell Biology
Shakti Ranjan Satapathy, Souvik Ghatak, Anita Sjoelander
Summary: This study investigates the role of the CysLT1R/Wnt/ss-catenin signaling pathway in regulating PD-L1 expression in colorectal cancer. The study shows that upregulation of CysLT1R enhances PD-L1 expression, and targeting CysLT1R with its antagonist or using CRISPR/Cas9-mediated inhibition reduces PD-L1 expression, potentially improving the efficacy of anti-PD-L1 therapy.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Nella Prevete, Remo Poto, Gianni Marone, Gilda Varricchi
Summary: N-formyl peptide receptors (FPRs) are widely distributed in immune and non-immune cells, recognizing N-formyl peptides and endogenous signals. FPR2 and/or FPR1 play significant roles in immunomodulation and maintaining tissue integrity. In the setting of heart injury, FPR2 activation on cardiac macrophages reduces infarct size and resolves inflammation. Further studies should explore FPR2's role in other cardiovascular disorders.
Article
Cell Biology
Sakura Fujisawa, Yuka Nagata, Ryo Suzuki
Summary: This study investigated the mechanisms underlying CysLT1R-mediated mast cell activation. The results showed that CysLT1R plays a major role in accelerating mast cell activation. CysLT1R enhances mast cell activation by accelerating IgE-induced signal transduction, enabling the co-regulation of rapid degranulation and delayed synthesis of inflammatory mediators.
CELLULAR IMMUNOLOGY
(2022)
Article
Immunology
Saltanat Ualiyeva, Evan Lemire, Evelyn C. Aviles, Caitlin Wong, Amelia A. Boyd, Juying Lai, Tao Liu, Ichiro Matsumoto, Nora A. Barrett, Joshua A. Boyce, Adam L. Haber, Lora G. Bankova
Summary: This study reveals that IL-25 and CysLTs from airway tuft cells synergistically promote type 2 inflammation, leading to lung inflammation and systemic immune response.
SCIENCE IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hana Seung, Jan Wrobel, Carolin Wadle, Timon Buehler, Diana Chiang, Jasmin Rettkowski, Nina Cabezas-Wallscheid, Beatrice Hechler, Peter Stachon, Alexander Maier, Christian Weber, Dennis Wolf, Daniel Duerschmied, Marco Idzko, Christoph Bode, Constantin von zur Muehlen, Ingo Hilgendorf, Timo Heidt
Summary: This study investigates the role of adenosine diphosphate (ADP)-dependent P2Y(12)-mediated signaling in emergency hematopoiesis and cardiac remodeling after myocardial infarction (MI). The results show that ADP acts as a danger signal, promoting emergency hematopoiesis through Akt phosphorylation and cell cycle progression. Inhibiting P2Y(12) can reduce emergency hematopoiesis, excessive inflammatory response, and improve cardiac function after MI.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Critical Care Medicine
Liang Zhao, Lulu Sun, Xiafei Li, Tian Lu, Yuxue Pan, Pengchong Du
Summary: This study elucidated the cardioprotective mechanism of genipin and demonstrated its potential for treating ischemic heart failure.
Article
Pharmacology & Pharmacy
Yanjun Gong, Minghui Lin, Lingjuan Piao, Xinzhi Li, Fei Yang, Jian Zhang, Bing Xiao, Qingli Zhang, Wen-Liang Song, Huiyong Yin, Li Zhu, Colin D. Funk, Ying Yu
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Medicine, Research & Experimental
Ankang Lu, Caojian Zuo, Yuhu He, Guilin Chen, Lingjuan Piao, Jian Zhang, Bing Xiao, Yujun Shen, Juan Tang, Deping Kong, Sara Alberti, Di Chen, Shenkai Zuo, Qianqian Zhang, Shuai Yan, Xiaochun Fei, Fei Yuan, Bin Zhou, Shengzhong Duan, Yu Yu, Michael Lazarus, Yunchao Su, Richard M. Breyer, Colin D. Funk, Ying Yu
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Review
Genetics & Heredity
Yuan Yan Sin, Garrett Baron, Andreas Schulze, Colin D. Funk
JOURNAL OF MOLECULAR MEDICINE-JMM
(2015)
Article
Cardiac & Cardiovascular Systems
Xinzhi Li, Laurel L. Ballantyne, Xinghui Che, Jeffrey D. Mewburn, Jing X. Kang, Robert M. Barkley, Robert C. Murphy, Ying Yu, Colin D. Funk
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2015)
Article
Cardiac & Cardiovascular Systems
Yujun Shen, Shengkai Zuo, Yuanyang Wang, Hongfei Shi, Shuai Yan, Di Chen, Bing Xiao, Jian Zhang, Yanjun Gong, Maohua Shi, Juan Tang, Deping Kong, Luheng Lu, Yu Yu, Bin Zhou, Sheng-Zhong Duan, Claudio Schneider, Colin D. Funk, Ying Yu
CIRCULATION RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk
JOURNAL OF LIPID RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk
JOURNAL OF LIPID RESEARCH
(2018)
Article
Multidisciplinary Sciences
Richard Yang Cao, Robert Eves, Lilly Jia, Colin D. Funk, Zongchao Jia, Alan S. Mak
Article
Biochemistry & Molecular Biology
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk
Article
Medicine, Research & Experimental
Yuan Yan Sin, Laurel L. Ballantyne, Christopher R. Richmond, Colin D. Funk
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Multidisciplinary Sciences
Laurel L. Ballantyne, Yuan Yan Sin, Tim St. Amand, Joshua Si, Steven Goossens, Lieven Haenebalcke, Jody J. Haigh, Lianna Kyriakopoulou, Andreas Schulze, Colin D. Funk
Article
Multidisciplinary Sciences
Yuan Yan Sin, Phillipe R. Price, Laurel L. Ballantyne, Colin D. Funk
SCIENTIFIC REPORTS
(2017)
Review
Virology
Colin D. Funk, Craig Laferriere, Ali Ardakani
Summary: The SARS-CoV-2 virus has caused a devastating global pandemic with millions infected and dead. Efforts have been made to develop vaccines, with several in advanced stages of clinical trials and receiving emergency use authorization. The global vaccine rollout is crucial in ending the pandemic.
Article
Pharmacology & Pharmacy
Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D. Funk, Jian Zhang, Ying Yu
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Genetics & Heredity
Laurel L. Ballantyne, Yuan Yan Sin, Osama Y. Al-Dirbashi, Xinzhi Li, David J. Hurlbut, Colin D. Funk
MOLECULAR GENETICS AND METABOLISM REPORTS
(2016)