Article
Cell Biology
Shakti Ranjan Satapathy, Souvik Ghatak, Anita Sjoelander
Summary: This study investigates the role of the CysLT1R/Wnt/ss-catenin signaling pathway in regulating PD-L1 expression in colorectal cancer. The study shows that upregulation of CysLT1R enhances PD-L1 expression, and targeting CysLT1R with its antagonist or using CRISPR/Cas9-mediated inhibition reduces PD-L1 expression, potentially improving the efficacy of anti-PD-L1 therapy.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Sakura Fujisawa, Yuka Nagata, Ryo Suzuki
Summary: This study investigated the mechanisms underlying CysLT1R-mediated mast cell activation. The results showed that CysLT1R plays a major role in accelerating mast cell activation. CysLT1R enhances mast cell activation by accelerating IgE-induced signal transduction, enabling the co-regulation of rapid degranulation and delayed synthesis of inflammatory mediators.
CELLULAR IMMUNOLOGY
(2022)
Article
Oncology
Ha Young Jang, In-Wha Kim, Jung Mi Oh
Summary: The study found that the use of LTRAs was associated with a decreased risk of cancer, especially when used in high dose and for a longer duration. The results could be utilized for developing new chemo-preventive regimens or designing feasible RCTs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ophthalmology
Susanne M. Brunner, Falk Schroedl, Julia Preishuber-Pfluegl, Christian Runge, Andreas Koller, Markus Lenzhofer, Herbert A. Reitsamer, Andrea Trost
Summary: This study describes and compares the expression patterns of CysLT system components in the eye of humans and animal models, revealing their expression in various ocular tissues. CysLTR1 is predominantly expressed in ocular epithelial cells, indicating its involvement in stress and immune responses. CysLTR2 is primarily expressed in neuronal structures, suggesting neuromodulatory roles in the eye.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yun Wu, Chen Cui, Fang-Fang Bi, Cheng-Yu Wu, Jin-Rui Li, Yu-Meng Hou, Ze-Hong Jing, Qing-Ming Pan, Miao Cao, Li-Fang Lv, Xue-Lian Li, Hong-Li Shan, Xin Zhai, Yu-Hong Zhou
Summary: Montelukast, a drug used for asthma, COPD, and allergic rhinitis, has been found to inhibit cardiac fibrosis by interacting with the APJ-mediated signaling pathway, suggesting its potential as a therapeutic target in heart fibrosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zsuzsanna Szabo, Balazs Dezso, Klara Fodor, Krisztian Szegedi, Tibor Flasko, Erzsebet Szabo, Gabor Olah, Eva Sipos, Nikoletta Dobos, Janos Gardi, Andrew V. Schally, Gabor Halmos
Summary: This study investigates the expression of LHRH and LHRH-R-I in transitional cell carcinoma (TCC) type of human bladder cancer, finding high incidence of expression of both in the samples examined. Positive immunostaining for LHRH-R-I with different expression intensity was found in all samples, showing a negative correlation with TCC grade.
Article
Veterinary Sciences
Ana Mafalda Rasteiro, Eva Sa e Lemos, Paula A. Oliveira, Rui M. Gil da Costa
Summary: Bladder cancer in veterinary medicine, particularly in companion animals, is still poorly understood but recent advances in identifying tumor markers and introducing targeted therapies have shown promise. This review focuses on small animal oncology and provides an update on the field, drawing comparisons with bladder cancer in humans and experimental models of the disease.
VETERINARY SCIENCES
(2022)
Article
Pathology
Malihe Eskandarpour, Yi-Hsing Chen, Miles A. Nunn, Sarah E. Coupland, Wynne Weston-Davies, Virginia L. Calder
Summary: Nomacopan, derived from tick saliva, has dual functions of sequestering LTB4 and inhibiting C5 activation. Studies show therapeutic benefit of Nomacopan in experimental autoimmune uveitis, with longer-acting forms proving more efficacious.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Qinchuan Wu, Caixu Pan, Yuan Zhou, Shuai Wang, Liting Xie, Wuhua Zhou, Limin Ding, Tianchi Chen, Junjie Qian, Rong Su, Xingxing Gao, Zhibin Mei, Yiting Qiao, Shengyong Yin, Yi Wu, Jieyi Wang, Lin Zhou, Shusen Zheng
Summary: This study found that PD-1 blockade potentially increases the accumulation of tumor CD4+ regulatory T cells (Tregs), mainly in lymphoid tissues rather than in the tumor. The study also discovered that neuropilin-1 (Nrp-1) supports Tregs migration behavior, and targeting Nrp-1 and 4-1BB can improve the HCC microenvironment and enhance the anti-tumor effect.
Article
Multidisciplinary Sciences
Wei Tan, Liang Gao, Ye Yuan, Hao Huang, Yadong Li, Yuanqing Gou, Zili Hu
Summary: Research has shown a higher occurrence of bladder cancer in men compared to women, leading researchers to investigate the role of androgen in bladder cancer. A study was conducted with 147 patients diagnosed with primary bladder cancer and 154 non-tumor patients as the control group. The results revealed a significant correlation between serum total testosterone levels and the occurrence of bladder cancer, along with other factors such as hemoglobin, hypertension, diabetes, and smoking.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Nathan Rabinovitch, Meaghan J. Jones, Nicole Gladish, Anna Faino, Matthew Strand, Alexander M. Morin, Julie MacIsaac, David T. S. Lin, Paul R. Reynolds, Amrit Singh, Erwin W. Gelfand, Michael S. Kobor, Christopher Carlsten
Summary: This study found that increased CysLT levels associated with diesel exhaust exposure may lead to lung function declines through alterations in CysLTR1-related methylation and gene expression.
Article
Multidisciplinary Sciences
Engin Kut, Serkan Menekse
Summary: This study investigated the relationship between thyroid transcription factor 1 (TTF-1) and brain metastases (BMs) in lung adenocarcinomas (ACs). The results showed a significant correlation between TTF-1 and survival time, suggesting that TTF-1 can be used as a biomarker to monitor prognosis in AC patients with BMs.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
H. von der Maase, S. W. Hansen, J. T. Roberts, L. Dogliotti, T. Oliver, M. J. Moore, I. Bodrogi, P. Albers, A. Knuth, C. M. Lippert, P. Kerbrat, P. Sanchez Rovira, P. Wersall, S. P. Cleall, D. F. Roychowdhury, I. Tomlin, C. M. Visseren-Grul, P. F. Conte
Summary: This study compared the effectiveness of GC and MVAC in patients with locally advanced or metastatic transitional-cell carcinoma. The results showed similar overall survival between the two groups, but GC had a better safety profile and tolerance. Therefore, GC should be the standard treatment for patients with locally advanced and metastatic TCC.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
John P. Stein, Gary Lieskovsky, Richard Cote, Susan Groshen, An-Chen Feng, Stuart Boyd, Eila Skinner, Bernard Bocher, Duriayai Thangathurai, Maged Mikhail, Derek Raghavan, Donald G. Skinner
Summary: This study evaluated the long-term clinical outcomes of patients with invasive bladder cancer who underwent radical cystectomy and pelvic lymph node dissection. The results showed that the primary bladder tumor stage and lymph node status were associated with the prognosis of patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min-Yung Kuo, Wei-Ting Yang, Yann-Jen Ho, Ge-Man Chang, Hsiung-Hao Chang, Chao-Yu Hsu, Chia-Che Chang, Yi-Hsin Chen
Summary: Bladder cancer is a common malignancy worldwide. STAT3 is a transcription factor commonly hyperactivated in cancers, including bladder cancer. HME, a compound derived from a medicinal mushroom, was found to be cytotoxic to bladder cancer cells by blocking STAT3 activation and suppressing the downstream survivin signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Kosaku Murakami, Masahiro Sekiguchi, Shintaro Hirata, Takao Fujii, Kiyoshi Matsui, Satoshi Morita, Koichiro Ohmura, Yutaka Kawahito, Norihiro Nishimoto, Tsuneyo Mimori, Hajime Sano, K. Maeda, H. Nakahara, S. Higa, Y. Hamano, M. Nishide, S. Nozaki, A. Yamamoto, Y. Kukita, T. Senoo, H. Nagahara, H. Hashimoto, A. Yokota, K. Miki, N. Shinmyo, T. Fujimura, H. Goto, M. Tada, T. Koike, Y. Sugioka, T. Okano, T. Fujimoto, Y. Ozaki, Y. Son, M. Kitano, S. Irimajiri, T. Hidaka, Y. Nozaki, M. Funauchi, S. Hino, M. Sugiyama, T. Shiga, T. Kuroiwa, I. Yoshii, M. Hashimoto, N. Yamakawa, K. Hatta, T. Azuma, T. Igawa, K. Inoue, T. Takeuchi, M. Tanaka, K. Higami, M. Namiki, T. Yamazaki, T. Nakatani, T. Saito, Y. Imura, T. Nakajima, S. Namiuchi, K. Akashi, M. Nakata, T. Takeuchi, A. Omoto, A. Nanpei, S. Watanabe, K. Ushio, Y. Hideki, S. Oshima, S. Kashiwagi, H. Yokoyama, M. Morimoto, Y. Uesugi, S. Mokuda, H. Yanagita, K. Sugimoto, T. Sasaki, A. Hashiramoto
MODERN RHEUMATOLOGY
(2019)
Editorial Material
Rheumatology
Yutaka Kawahito
MODERN RHEUMATOLOGY
(2019)
Article
Rheumatology
Shunya Kaneshita, Takashi Kida, Isao Yokota, Hidetake Nagahara, Takahiro Seno, Makoto Wada, Masataka Kohno, Yutaka Kawahito
MODERN RHEUMATOLOGY
(2020)
Article
Rheumatology
Takashi Kida, Tadashi Tanaka, Isao Yokota, Keiichi Tamagaki, Tomoya Sagawa, Masatoshi Kadoya, Takahiro Yamada, Kazuki Fujioka, Makoto Wada, Masataka Kohno, Noriya Hiraoka, Atsushi Omoto, Wataru Fukuda, Yutaka Kawahito
MODERN RHEUMATOLOGY
(2020)
Article
Rheumatology
Takashi Kida, Atsushi Umemura, Shunya Kaneshita, Risa Sagawa, Takuya Inoue, Shogo Toyama, Makoto Wada, Masataka Kohno, Ryo Oda, Tohru Inaba, Yoshito Itoh, Yutaka Kawahito
MODERN RHEUMATOLOGY
(2020)
Review
Rheumatology
Yuko Kaneko, Yutaka Kawahito, Masayo Kojima, Takeo Nakayama, Shintaro Hirata, Mitsumasa Kishimoto, Hirahito Endo, Yohei Seto, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Toshihisa Kojima, Naoyuki Kamatani, Kiichiro Tsutani, Ataru Igarashi, Mieko Hasegawa, Nobuyuki Miyasaka, Hisashi Yamanaka
Summary: Tacrolimus shows effective outcomes and acceptable safety profile in managing RA patients, significantly improving ACR20 achievement rates with tolerable adverse effects.
MODERN RHEUMATOLOGY
(2021)
Article
Environmental Sciences
Tomoya Sagawa, Takahiro Tsujikawa, Akiko Honda, Natsuko Miyasaka, Michitaka Tanaka, Takashi Kida, Koichi Hasegawa, Tomoaki Okuda, Yutaka Kawahito, Hirohisa Takano
Summary: The study used a mouse model exposed to particulate matter to evaluate the increased expression of ACE2 and TMPRSS2 in the lungs, which are required for the entry of SARS-CoV-2. The findings suggest that particulate matter may enhance the expression of these proteins in alveolar type 2 cells and macrophages, potentially making them targets for SARS-CoV-2. This research provides insight into how air pollution could influence the severity of COVID-19 infection.
ENVIRONMENTAL RESEARCH
(2021)
Review
Rheumatology
Eiichi Tanaka, Yutaka Kawahito, Masataka Kohno, Shintaro Hirata, Mitsumasa Kishimoto, Yuko Kaneko, Hiroya Tamai, Yohei Seto, Akio Morinobu, Takahiko Sugihara, Atsuko Murashima, Masayo Kojima, Masaaki Mori, Hiromu Ito, Toshihisa Kojima, Yasumori Sobue, Keiichiro Nishida, Isao Matsushita, Takeo Nakayama, Hisashi Yamanaka, Masayoshi Harigai
Summary: The systematic review of 20 randomized controlled trials showed that biosimilars and reference bDMARDs were equally effective and safe for managing rheumatoid arthritis.
MODERN RHEUMATOLOGY
(2022)
Article
Rheumatology
Takahiko Sugihara, Yutaka Kawahito, Akio Morinobu, Yuko Kaneko, Yohei Seto, Toshihisa Kojima, Hiromu Ito, Masataka Kohno, Takeo Nakayama, Yasumori Sobue, Keiichiro Nishida, Isao Matsushita, Atsuko Murashima, Masaaki Mori, Eiichi Tanaka, Shintaro Hirata, Mitsumasa Kishimoto, Hisashi Yamanaka, Masayo Kojima, Masayoshi Harigai
Summary: This study aims to provide an evidence base for developing CPG for the management of rheumatoid arthritis in older adults, by conducting a systematic literature review and assessing the quality of evidence, yielding conclusions on the efficacy and safety of different drug treatments for older RA patients.
MODERN RHEUMATOLOGY
(2022)
Article
Rheumatology
Hiromu Ito, Koichi Murata, Yasumori Sobue, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Yutaka Kawahito, Masayo Kojima, Shintaro Hirata, Yuko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Masaaki Mori, Akio Morinobu, Atsuko Murashima, Yohei Seto, Takahiko Sugihara, Eiichi Tanaka, Takeo Nakayama, Masayoshi Harigai
Summary: This study examined the risk factors of surgical site infection, delayed wound healing, and death after orthopedic surgery in patients with rheumatoid arthritis. The use of biological disease modifying antirheumatic drugs was identified as a risk factor for surgical site infection, while rheumatoid arthritis itself, oral glucocorticoid use, age, male sex, comorbidities such as diabetes mellitus and chronic obstructive pulmonary disease, surgical factors, and longer operative time were all found to be risk factors for postoperative complications. Patients with these factors should be carefully monitored to ensure a balance between risks and benefits of orthopedic surgeries.
MODERN RHEUMATOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Tomoya Sagawa, Akiko Honda, Raga Ishikawa, Natsuko Miyasaka, Megumi Nagao, Sakiko Akaji, Takashi Kida, Takahiro Tsujikawa, Tatsushi Yoshida, Yutaka Kawahito, Hirohisa Takano
Summary: The study showed that exposure to titanium dioxide nanoparticles induced leukocyte migration into the alveolar region and increased secretion of C-C motif ligand (CCL) 3 in bronchoalveolar lavage (BAL) fluid. Macrophages in the lungs phagocytosed the TiO2 nanoparticles and underwent necroptosis, resulting in the translocation of high mobility group box-1 from the cell nucleus to the cytoplasm. Necroptosis of the phagocytosing macrophages was found to be involved in the mechanism by which titanium dioxide induces acute lung inflammation.
Article
Multidisciplinary Sciences
Yutaka Kawahito, Yuya Takakubo, Akio Morinobu, Naoko Matsubara, Orsolya Nagy, Eiji Sugiyama
Summary: Although most Japanese patients with RA with moderate-to-high disease activity were dissatisfied with their current DMARD treatment, high treatment adherence, high acceptability of combination therapy, high acceptability of manageable potential side effects, and preference for oral medication were reported. Data support the development of a more individualized and patient-centric approach for RA treatment.
Article
Rheumatology
Yutaka Kawahito, Akio Morinobu, Yuko Kaneko, Masataka Kohno, Shintaro Hirata, Mitsumasa Kishimoto, Yohei Seto, Takahiko Sugihara, Eiichi Tanaka, Hiromu Ito, Toshihisa Kojima, Isao Matsushita, Keiichiro Nishida, Masaaki Mori, Atsuko Murashima, Hisashi Yamanaka, Takeo Nakayama, Masayo Kojima, Masayoshi Harigai
Summary: The Japan College of Rheumatology has updated the clinical practice guidelines for rheumatoid arthritis, providing a useful tool for rheumatologists, healthcare professionals, and patients to make shared decisions in various clinical situations.
MODERN RHEUMATOLOGY
(2023)
Article
Infectious Diseases
Wataru Fujii, Liu Chang, Taka-aki Inui, Shigeyasu Ishizaka, Yutaka Kawahito
Summary: A female patient with rheumatoid arthritis treated with JAK inhibitors developed gradually enlarging bilateral submandibular lymph nodes swelling. Lymph node biopsy revealed granulomatous lymphadenitis with caseous necrosis, and Mycobacterium avium was identified. A CT scan showed no evidence of mass or infection elsewhere, and the mass was excised without antimicrobial treatment. No recurrence was observed 9 months after excision. Physicians should be aware of rare complications such as cervical lymphadenitis caused by nontuberculous mycobacteria when using JAK inhibitors.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Respiratory System
Masataka Kuwana, Masashi Bando, Yutaka Kawahito, Shinji Sato, Takafumi Suda, Yasuhiro Kondoh, CTD-ILD Delphi Collaborators
Summary: The study aimed to develop expert consensus statements and an algorithm for managing connective tissue disease-associated interstitial lung disease (CTD-ILD). Consensus was reached on important statements regarding screening, diagnosis and severity assessment, follow-up, and multidisciplinary management of CTD-ILD. An algorithm was developed based on these consensus statements.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
