Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker

Modified nucleotides may have enhanced early RNA catalysis

(2020) Steven K. Wolk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader

(2019) Shaolin Liang et al.   Nature Communications

Hachimoji DNA and RNA: A genetic system with eight building blocks

(2019) Shuichi Hoshika et al.   SCIENCE

Side chain determinants of biopolymer function during selection and replication

(2019) Phillip A. Lichtor et al.   Nature Chemical Biology

Not Your Usual Bioisostere: Solid State Study of 3D Interactions in Cubanes

(2019) Keith J. Flanagan et al.   CHEMISTRY-A EUROPEAN JOURNAL

A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids

(2019) Sebastian Arangundy-Franklin et al.   Nature Chemistry

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

(2019) Elena Eremeeva et al.   NUCLEIC ACIDS RESEARCH

Eight-Letter DNA

(2019) Vivian T. Dien et al.   BIOCHEMISTRY

Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics

(2019) Alexander I. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Aptamer chemistry

(2018) Pascal Röthlisberger et al.   ADVANCED DRUG DELIVERY REVIEWS

Aptamer-mediated Plasmodium -specific diagnosis of malaria

(2018) Yee-Wai Cheung et al.   BIOCHIMIE

A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis

(2018) Lewis A. Fraser et al.   BIOSENSORS & BIOELECTRONICS

Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues

(2018) Hui Mei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of sequence-defined highly functionalized nucleic acid polymers

(2018) Zhen Chen et al.   Nature Chemistry

Identification and characterization of nucleobase-modified aptamers by click-SELEX

(2018) Franziska Pfeiffer et al.   Nature Protocols

Aptamers in the Therapeutics and Diagnostics Pipelines

(2018) Harleen Kaur et al.   Theranostics

Cubanes in Medicinal Chemistry

(2018) Tristan A. Reekie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

DNA Aptamers for the Functionalisation of DNA Origami Nanostructures

(2018) Yusuke Sakai et al.   Genes

In Vitro Selection of Diversely Functionalized Aptamers

(2017) Dehui Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Whole cell-SELEX of aptamers with a tyrosine-like side chain against live bacteria

(2017) Marleen Renders et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Selection of DNA aptamers with two modified bases

(2017) Bharat N. Gawande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers

(2017) Zhixia Liu et al.   Chemical Science

Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling

(2017) Xiaoming Ren et al.   Nature Communications

Analysis of aptamer discovery and technology

(2017) Matthew R. Dunn et al.   Nature Reviews Chemistry

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

(2016) Benjamin A. Chalmers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Embracing proteins: structural themes in aptamer–protein complexes

(2016) Amy D Gelinas et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Development of Aptamer-Based Point-of-Care Diagnostic Devices for Malaria Using Three-Dimensional Printing Rapid Prototyping

(2016) Roderick M. Dirkzwager et al.   ACS Sensors

APTEC: aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria

(2015) Roderick M. Dirkzwager et al.   CHEMICAL COMMUNICATIONS

Cubane: 50 Years Later

(2015) Kyle F. Biegasiewicz et al.   CHEMICAL REVIEWS

SELEX: How It Happened and Where It will Go

(2015) Larry Gold   JOURNAL OF MOLECULAR EVOLUTION

Evolution of Functional Six-Nucleotide DNA

(2015) Liqin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

(2014) Shashi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A semi-synthetic organism with an expanded genetic alphabet

(2014) Denis A. Malyshev et al.   NATURE

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

(2014) John C Rohloff et al.   Molecular Therapy-Nucleic Acids

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

pLDH level of clinically isolated Plasmodium vivax and detection limit of pLDH based malaria rapid diagnostic test

(2013) Jin Jang et al.   MALARIA JOURNAL

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

(2013) Michiko Kimoto et al.   NATURE BIOTECHNOLOGY

Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer

(2013) Y.-W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Advances in human proteomics at high scale with the SOMAscan proteomics platform

(2011) Larry Gold et al.   New Biotechnology

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Expanding the Chemistry of DNA for in Vitro Selection

(2010) Jonathan D. Vaught et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY