Autophagy Dysfunction and Oxidative Stress, Two Related Mechanisms Implicated in Retinitis Pigmentosa

The mechanism of cone cell death in Retinitis Pigmentosa

(2018) Peter A. Campochiaro et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa

(2017) Huan Yang et al.   Molecular Neurodegeneration

Neurodegeneration: Keeping ATF4 on a Tight Leash

(2017) Priyamvada M. Pitale et al.   Frontiers in Cellular Neuroscience

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

(2017) Filippo Scialò et al.   Frontiers in Physiology

Autophagy-mediated catabolism of visual transduction proteins prevents retinal degeneration

(2016) Jingyu Yao et al.   Autophagy

Why autophagy is good for retinal ganglion cells?

(2016) P Boya   EYE

The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword

(2016) Peiwei Chai et al.   International Journal of Biological Sciences

Looking into aqueous humor through metabolomics spectacles − exploring its metabolic characteristics in relation to myopia

(2016) Cecilia Barbas-Bernardos et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

(2016) Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in the eye: Development, degeneration, and aging

(2016) Patricia Boya et al.   PROGRESS IN RETINAL AND EYE RESEARCH

TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome

(2016) A Venkatesh et al.   Cell Death & Disease

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

(2016) Yogesh Bhootada et al.   PLoS One

Carnosic acid slows photoreceptor degeneration in the Pde6b rd10 mouse model of retinitis pigmentosa

(2016) Kai Kang et al.   Scientific Reports

Ultrastructural relationship of the phagophore with surrounding organelles

(2015) Joanna Biazik et al.   Autophagy

Autophagy supports survival and phototransduction protein levels in rod photoreceptors

(2015) Z Zhou et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective actions of progesterone in an in vivo model of retinitis pigmentosa

(2015) V. Sánchez-Vallejo et al.   PHARMACOLOGICAL RESEARCH

PGC-1α Signaling Coordinates Susceptibility to Metabolic and Oxidative Injury in the Inner Retina

(2014) Xiaoxin Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in the eye: Implications for ocular cell health

(2014) Laura S. Frost et al.   EXPERIMENTAL EYE RESEARCH

A growing role for mTOR in promoting anabolic metabolism

(2013) Jessica J. Howell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism

(2013) Junyu Zhang et al.   BIOMATERIALS

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagic Processes in Yeast: Mechanism, Machinery and Regulation

(2013) F. Reggiori et al.   GENETICS

Autophagy Protects the Retina from Light-induced Degeneration

(2013) Yu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optical imaging of mitochondrial redox state in rodent model of retinitis pigmentosa

(2013) Sepideh Maleki et al.   JOURNAL OF BIOMEDICAL OPTICS

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Receptor protein complexes are in control of autophagy

(2012) Dalibor Mijaljica et al.   Autophagy

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic Challenges to Retinitis Pigmentosa: From Neuroprotection to Gene Therapy

(2011) Jayashree N. Sahni et al.   CURRENT GENOMICS

Overexpression of SOD in retina: Need for increase in H2O2-detoxifying enzyme in same cellular compartment

(2011) Shinichi Usui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Daylight Vision in Retinal Degeneration: Are Oxidative Stress and Metabolic Dysregulation to Blame?

(2011) Claudio Punzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of mitochondria in neurodegenerative diseases

(2011) Massimiliano Filosto et al.   JOURNAL OF NEUROLOGY

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

(2010) M. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRTs and human disease

(2009) Suraj Saksena et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease

(2009) Anne N. Murphy   EMBO Molecular Medicine

NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa

(2009) Shinichi Usui et al.   JOURNAL OF NEUROCHEMISTRY

Murine muscle cell models for Pompe disease and their use in studying therapeutic approaches

(2009) Shoichi Takikita et al.   MOLECULAR GENETICS AND METABOLISM

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial DNA damage and its potential role in retinal degeneration

(2008) S JARRETT et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The locations of mitochondria in mammalian photoreceptors: Relation to retinal vasculature

(2007) Jonathan Stone et al.   BRAIN RESEARCH

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

(2007) John et al.   Frontiers in Bioscience-Landmark