High Glucose‐Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells

CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells

(2019) Fang Bian et al.   Frontiers in Pharmacology

Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose Tolerant Subjects

(2019) Devjit Tripathy et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

(2018) Tao Zheng et al.   Oxidative Medicine and Cellular Longevity

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

(2017) Wenjing Luo et al.   Scientific Reports

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages

(2017) Xiaotian Zhang et al.   Journal of Diabetes Research

TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance

(2017) Wenjing Li et al.   Scientific Reports

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver innate immune cells and insulin resistance: the multiple facets of Kupffer cells

(2016) J. Jager et al.   JOURNAL OF INTERNAL MEDICINE

Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response

(2016) Shyam Sundhar Bale et al.   Scientific Reports

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells

(2015) Udayakumar Karunakaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway

(2015) Tao Zheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Activated Kupffer cells inhibit insulin sensitivity in obese mice

(2015) Michaela Tencerova et al.   FASEB JOURNAL

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion

(2014) Hyo-Yeon Kim et al.   FEBS Journal

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice

(2014) Hongming Miao et al.   Cell Reports

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells

(2011) Chin-Lin Hsu et al.   Food & Function

Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice

(2010) Manabu Kinoshita et al.   JOURNAL OF HEPATOLOGY

Kupffer cell activation is a causal factor for hepatic insulin resistance

(2009) Nicolas Lanthier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY