Article
Medicine, Research & Experimental
Xinfei Ma, Qinli Ruan, Xiaotian Ji, Ju Yang, Huiping Peng
Summary: The study demonstrated that Ligustrazine had protective effects against hepatotoxicity induced by Cyclophosphamide or its metabolite 4-hydroperoxycyclophosphamide, by improving liver structure and function, inhibiting oxidative stress and inflammation accompanied with pyroptosis, which was associated with the inhibition of the Txnip/Trx/NF-kappa B pathway.
Article
Chemistry, Medicinal
Kun Yan, Jianqiang Hu, Tianhua Hou, Xinxin Ci, Liping Peng
Summary: This study demonstrates that Leonurine (Leo) can effectively protect against carrageenan-induced pleurisy by inhibiting the TXNIP/NLRP3 and NF-kappa B pathways through activating the Nrf2 pathway, which may serve as a promising agent for attenuating pleurisy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Yixiao Wang, Yan Cao, Xiaohong Ji, Ting Li, Lu Xue, Chanjuan Li, Ruizhe Jia, Hongjuan Ding
Summary: The study demonstrated that AEDPPE enhances trophoblast migration and invasion, reduces inflammatory cytokine expression, and may exert these effects through the NF-kappa B signaling pathway. In the PE-like rat model, AEDPPE showed significant improvement in PE symptoms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jing Ren, Xiumei Feng, Yanan Guo, Dexiao Kong, Yongjing Wang, Juan Xiao, Wen Jiang, Xiaoli Feng, Xiaoli Liu, Ai Li, Congcong Sun, Mingming He, Bingen Li, Juandong Wang, Yang Jiang, Chengyun Zheng
Summary: The GSK-3 beta inhibitor, TWS119, enhances the cytotoxicity of NK cells against multiple myeloma cells by upregulating RAB27A expression and activating the beta-catenin/NF-kappa B pathway. In vivo experiments demonstrated that adoptive transfer of TWS119-treated NK-92 cells significantly reduces tumor volume and prolongs the survival time of myeloma-bearing mice.
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Chen Liu, Sujuan Lei, Tianying Cai, Yonglang Cheng, Junjie Bai, Wenguang Fu, Meizhou Huang
Summary: This study elucidates the role of iNOS in vascular endothelial dysfunction through cellular experiments and metabolic analysis. The findings suggest that iNOS deficiency can reverse the pathological changes induced by TNF-α and alleviate vascular endothelial dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Huajie Mao, Ya Zhao, Li Lei, Yanxia Hu, Hangrui Zhu, Runzhi Wang, Dongsheng Ni, Jianing Liu, Lei Xu, Hua Xia, Zaikuan Zhang, Meng Ma, Zheng Pan, Qin Zhou, Yajun Xie
Summary: SELS is highly expressed in clear cell renal cell carcinoma (ccRCC) and associated with multiple pathological features. SELS overexpression promotes cell proliferation and inhibits apoptosis, while silence of SELS has the opposite effect. Mechanistically, SELS activates AKT/GSK3 beta/NF-kappa B signaling pathway to enhance cell proliferation and inhibit apoptosis, and stabilizes c-Myc by preventing ubiquitin-proteasome-mediated degradation. Furthermore, SELS inhibits ccRCC cell migration likely through repressing epithelial-mesenchymal transition (EMT).
Article
Cell Biology
Yang Nan, Liyun Guo, Yingwei Zhen, Le Wang, Bingcheng Ren, Xingjie Chen, Yalin Lu, Kai Yu, Yue Zhong, Qiang Huang
Summary: The study found that miRNA-451 regulates the NF-kappa B signaling pathway by targeting IKK beta, inhibiting the growth and invasion ability of glioma cells. Overexpression of miRNA-451 decreased the expression of IKK beta and other proteins, leading to reduced cell proliferation and invasion.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Review
Immunology
Cise Kizilirmak, Marco E. Bianchi, Samuel Zambrano
Summary: The transcription factor family NF-kappa B plays a crucial role in inflammation and immunity. Live cell imaging has revealed the dynamic nature of NF-kappa B activation, including oscillations in its nuclear localization. This interdisciplinary research has provided insights into the heterogeneous response of NF-kappa B in different cell types and its impact on gene expression. Future steps in this field should focus on filling existing knowledge gaps.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yongguang Zhang, Dongya Cui, Miaohui Huang, Yongwei Zheng, Baijiao Zheng, Liling Chen, Qi Chen
Summary: The protein NONO is a multifunctional nuclear protein that regulates transcriptional regulation, mRNA splicing, and DNA repair. This study shows that NONO has a critical role in B-cell development and B-cell activation. Deletion of NONO impairs early B-cell development and B-cell maturation, as well as the activation of pathways involved in B-cell activation, such as ERK, AKT, and NF-kappa B.
Article
Multidisciplinary Sciences
Kelly A. McCorkell, Nipun Jayachandran, Michelle D. Cully, Jacquelyn Freund-Brown, Tiffany Weinkopff, James Monslow, Yinling Hu, Ellen Pure, Bruce D. Freedman, Jorge Alvarez, Michael P. Cancro, Michael J. May
Summary: Global inactivation of IKK-alpha leads to defective lymph node formation and B cell maturation. IKK-alpha in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and LEC-intrinsic IKK-alpha is absolutely essential for LN formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Hongdian Zhang, Youming Han, Wanyi Xiao, Yongyin Gao, Zhilin Sui, Peng Ren, Fanbiao Meng, Peng Tang, Zhentao Yu
Summary: This study reveals that USP4 plays a crucial role in the progression of esophageal squamous cell carcinoma (ESCC) by modulating proliferation, migration, and invasion. USP4 interacts with TAK1 and stabilizes its protein levels in ESCC cells. Additionally, USP4 promotes ESCC progression through the activation of the MEK/ERK signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Jian-shuai Yu, Tao Huang, Yu Zhang, Xin-tao Mao, Ling-jie Huang, Yi-ning Li, Ting-ting Wu, Jiang-yan Zhong, Qian Cao, Yi-yuan Li, Jin Jin
Summary: The classic NF-kappa B pathway is crucial in immune responses and inflammatory diseases. This study showed that IKK beta ubiquitination on lysine-238 increases during inflammation, with USP16 identified as a key regulator affecting p105 phosphorylation. Elevated expression of USP16 in colon macrophages of IBD patients and conditional knockout of USP16 in myeloid cells resulted in reduced severity of IBD, providing insights for targeted intervention therapy.
Review
Physiology
Qianqian Chen, Hao Ji, Yue Lin, Zheyan Chen, Yinai Liu, Libo Jin, Renyi Peng
Summary: The increasing incidence of diabetes and its complications poses a serious threat to human health worldwide. Ferroptosis is closely related to diabetes and its complications, and long non-coding RNAs (lncRNAs) play a crucial role in regulating ferroptosis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jae-Wook Chung, Yeong-Seon Park, Jeong-Eon Seo, Yeseul Son, Cheol-Woo Oh, Chan-Hee Lee, Jong-Ho Nam, Jung-Hee Lee, Jang-Won Son, Ung Kim, Jong-Seon Park, Kyu-Chang Won, Dong-Gu Shin
Summary: This study found that dysglycemia, especially hyperglycemia, may be associated with myocardial injury in patients with AMIs, leading to an increased 30-day mortality. An admission glucose level greater than 202.5 mg/dL was found to be a more accurate predictor of mortality.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
Summary: Brief Summary: The study demonstrates that pioglitazone selectively protects beta cells against high glucose-induced dysfunction by activating the AMPK and GLS1 axis, resulting in elevated GSH/GSSG ratio and inhibition of mitochondrial dysfunction.
Review
Cell Biology
Suma Elumalai, Udayakumar Karunakaran, Jun-Sung Moon, Kyu-Chang Won
Summary: In type 2 diabetes, metabolic stress negatively affects pancreatic beta-cell function and survival. Imbalance in redox homeostasis causes abnormal tissue damage and beta-cell death, making beta-cells more susceptible to oxidative damage by NADPH oxidase.
Article
Endocrinology & Metabolism
Seung Min Chung, Min Kyu Kang, Jinho Jung, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee, Rohit Loomba, Jung Gil Park, Jun Sung Moon
Summary: The study investigated the long-term effect of changes in hepatic steatosis on the risk of developing T2DM, finding that patients with persistent steatosis had a higher risk of diabetes. The initial severity and aggravation of steatosis are independent predictors of future development of T2DM.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Hematology
Il Rae Park, Jimi Choi, Eun Young Ha, Seung Min Chung, Jun Sung Moon, Sehyun Shin, Sin Gon Kim, Kyu Chang Won
Summary: This study investigated the diagnostic potential of a hemorheological parameter, critical shear stress (CSS), for diabetic kidney disease (DKD), and found that CSS can be used as an additive diagnostic index for DKD. In combination with albumin-to-creatinine ratio (ACR) and glomerular filtration rate (GFR), CSS can identify DKD more accurately.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2022)
Article
Endocrinology & Metabolism
Jae Hyun Bae, Kyung-Do Han, Seung-Hyun Ko, Ye Seul Yang, Jong Han Choi, Kyung Mook Choi, Hyuk-Sang Kwon, Kyu Chang Won
Summary: This study investigated the prevalence and management of diabetes mellitus in Korea. The results showed high prevalence of diabetes among Korean adults, with only a small percentage of patients achieving glycemic, blood pressure, and lipid controls. The study also highlighted gender differences in self-management behaviors.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Medical Laboratory Technology
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
Summary: Chronic oxidative stress plays a key role in beta-cell loss in diabetes, and recent studies have linked this loss to ferroptotic-like death. Oxidative stress leads to the loss of reduced/oxidized glutathione and degradation of glutathione peroxidase 4, promoting lipid peroxidation and ferroptotic-like cell damage. Inhibiting the c-Abl kinase and inducing ERRy preserves beta-cell function by increasing the GSH/GSSG ratio and inhibiting lipid peroxidation. This study provides evidence that ERRy-induced GLS1 expression augments the glutathione antioxidant system, improving beta-cell function and survival under oxidative stress conditions.
TRANSLATIONAL RESEARCH
(2022)
Article
Medicine, General & Internal
Seong Ho Kim, Ji Young Kim, Eun Song Kim, Il Rae Park, Eun Yeong Ha, Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Summary: This study found that early glycaemic variability (GV) is associated with increased 28-day mortality and prolonged ICU stay in critically ill patients with pneumonia. The presence of diabetes or HbA1c levels alone cannot predict the mortality and ICU stay in these patients. Patients with high GV, especially those with diabetes or low HbA1c levels, should be carefully treated to reduce mortality and prolong ICU stay.
ANNALS OF MEDICINE
(2022)
Article
Environmental Sciences
Seung Min Chung, Dong-Gyu Heo, Ju-Hyun Kim, Ji Sung Yoon, Hyoung Woo Lee, Jong-Yeon Kim, Jun Sung Moon, Kyu Chang Won
Summary: This study aimed to investigate the association between serum levels of PFOA and PFOS and diabetes. The results showed that exposure to PFOA and PFOS may have a detrimental effect on blood glucose, with particularly high risk for diabetes in individuals exposed to PFOA.
ENVIRONMENTAL HEALTH
(2022)
Article
Endocrinology & Metabolism
Yong-ho Lee, Doo-Man Kim, Jae Myung Yu, Kyung Mook Choi, Sin Gon Kim, Kang Seo Park, Hyun-Shik Son, Choon Hee Chung, Kyu Jeung Ahn, Soon Hee Lee, Ki-Ho Song, Su Kyoung Kwon, Hyeong Kyu Park, Kyu Chang Won, Hak Chul Jang
Summary: This study compared the effects of anagliptin 100 mg BID versus sitagliptin 100 mg QD on managing glycaemic variability and found that the anagliptin BID regimen was superior in blood glucose control after dinner, as indicated by MAGE and TIR, but was equivalent to the QD regimen in terms of HbA1c and FPG.
DIABETES OBESITY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Suma Elumalai, Udayakumar Karunakaran, Jun-Sung Moon, Kyu-Chang Won
Summary: Metabolic stress impairs pancreatic beta-cell survival and function, which is associated with the imbalance in redox equilibrium and ferroptotic-like malfunction in beta-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jun Sung Moon, Nam Hoon Kim, Jin Oh Na, Jae Hyoung Cho, In-Kyung Jeong, Soon Hee Lee, Ji-Oh Mok, Nan Hee Kim, Dong Jin Chung, Jinhong Cho, Dong Woo Lee, Sun Woo Lee, Kyu Chang Won
Summary: This study evaluated the safety and effectiveness of empagliflozin in Korean patients with type 2 diabetes mellitus. It was found that empagliflozin had a good glycemic and weight-reducing effect, with no serious adverse events.
DIABETES & METABOLISM JOURNAL
(2023)
Review
Endocrinology & Metabolism
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
Summary: Diabetes mellitus is a significant risk factor for heart failure, with worse prognosis in diabetic patients. Early diagnosis and proper management of heart failure in diabetic patients are crucial. This review discusses the diagnosis criteria, screening tools, recommended pharmacological therapies, and effects of anti-diabetic medications on heart failure.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Endocrinology & Metabolism
Ye Seul Yang, Kyung Wan Min, Seok-O Park, Kyung-Soo Kim, Jae Myung Yu, Eun-Gyoung Hong, Sung Rae Cho, Kyu Chang Won, Yong Hyun Kim, Seungjoon Oh, Sung Hee Choi, Gwanpyo Koh, Wan Huh, Su Young Kim, Kyong Soo Park
Summary: This study aimed to evaluate and compare the efficacy and safety of enavogliflozin, a newly developed sodium-glucose cotransporter 2 inhibitor, with placebo in Korean patients with type 2 diabetes mellitus. The results showed that once-daily enavogliflozin monotherapy for 12 weeks is an effective, safe, and well-tolerated treatment for Korean patients with type 2 diabetes mellitus.
DIABETES OBESITY & METABOLISM
(2023)
Article
Environmental Sciences
Suma Elumalai, Udayakumar Karunakaran, Kyu Chang Won, Seung Min Chung, Jun Sung Moon
Summary: Chronic exposure to perfluorooctane sulfonate (PFOS) stimulates insulin secretion from pancreatic β-cells through the activation of RAC1-NOX2/gp91phox and inhibition of cAMP/PKA signaling, resulting in mitochondrial dysfunction and endoplasmic stress. Inhibition of RAC1-NOX2/gp91phox activation or elevation of cAMP levels restores insulin secretory function. However, inhibition of cAMP/PKA signaling impairs pentoxifylline-induced insulin secretion. Overall, our study reveals the direct chronic effect of PFOS on β-cell failure and suggests potential therapeutic targets for PFOS-induced β-cell dysfunction.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)