Endothelial Tip Cells in Ocular Angiogenesis

CD34 marks angiogenic tip cells in human vascular endothelial cell cultures

(2012) Martin J. Siemerink et al.   ANGIOGENESIS

A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy

(2012) Rob J Van Geest et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Extrinsic Notch Ligand Delta-Like 1 Regulates Tip Cell Selection and Vascular Branching Morphogenesis

(2012) L.C. Napp et al.   CIRCULATION RESEARCH

miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development

(2012) Stefania Nicoli et al.   DEVELOPMENTAL CELL

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly

(2012) Evelyne Frijns et al.   MOLECULAR BIOLOGY OF THE CELL

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

(2012) Rui Benedito et al.   NATURE

New pathways and mechanisms regulating and responding to Delta-like ligand 4–Notch signalling in tumour angiogenesis

(2011) Chern Ein Oon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

miR-27b controls venous specification and tip cell fate

(2011) D. Biyashev et al.   BLOOD

How Blood Vessel Networks Are Made and Measured

(2011) John C. Chappell et al.   CELLS TISSUES ORGANS

Laminin-Binding Integrins Induce Dll4 Expression and Notch Signaling in Endothelial Cells

(2011) Soline Estrach et al.   CIRCULATION RESEARCH

CXCL12 (SDF1 )-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

(2011) D. G. Duda et al.   CLINICAL CANCER RESEARCH

Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo

(2011) J. Krueger et al.   DEVELOPMENT

The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner

(2011) Ayako Nakamura-Ishizu et al.   DEVELOPMENTAL BIOLOGY

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

(2011) Denise Stenzel et al.   EMBO REPORTS

MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors

(2011) Yanyan Bai et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

(2011) Yoko Fukushima et al.   JOURNAL OF CLINICAL INVESTIGATION

A Human Neutralizing Antibody Specific to Ang-2 Inhibits Ocular Angiogenesis

(2011) EMMA S. RENNEL et al.   MICROCIRCULATION

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

(2011) Tuomas Tammela et al.   NATURE CELL BIOLOGY

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions

(2011) Xiao Dong et al.   PLoS One

Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

(2011) Mattias Kalén et al.   PLoS One

N-CAM Exhibits a Regulatory Function in Pathological Angiogenesis in Oxygen Induced Retinopathy

(2011) Joakim Håkansson et al.   PLoS One

MicroRNA regulation in angiogenesis

(2011) Andrea Caporali et al.   VASCULAR PHARMACOLOGY

Apelin Is a Crucial Factor for Hypoxia-Induced Retinal Angiogenesis

(2010) Atsushi Kasai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

(2010) H. Sheldon et al.   BLOOD

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

(2010) G. A. Strasser et al.   BLOOD

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

(2010) Dusan Djokovic et al.   BMC CANCER

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis

(2010) Luqing Zhang et al.   CELL RESEARCH

Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity

(2010) Federico Galvagni et al.   CIRCULATION RESEARCH

Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy

(2010) Michael H. Davies et al.   DEVELOPMENTAL DYNAMICS

Diabetic Retinopathy: Targeting Vasoregression

(2010) H.-P. Hammes et al.   DIABETES

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

(2010) Ingrid Nilsson et al.   EMBO JOURNAL

Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding

(2010) M. L. Bochenek et al.   JOURNAL OF CELL SCIENCE

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma

(2010) B K Haller et al.   ONCOGENE

Animal models of choroidal and retinal neovascularization

(2010) Hans E. Grossniklaus et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Axon Guidance Molecules in Vascular Patterning

(2010) R. H. Adams et al.   Cold Spring Harbor Perspectives in Biology

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Jagged Gives Endothelial Tip Cells an Edge

(2009) Steven Suchting et al.   CELL

The Extracellular Matrix of Blood Vessels

(2009) Johannes Eble et al.   CURRENT PHARMACEUTICAL DESIGN

Cellular and Molecular Mechanisms of Vascular Lumen Formation

(2009) M. Luisa Iruela-Arispe et al.   DEVELOPMENTAL CELL

Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP

(2009) Steven Budd et al.   EXPERIMENTAL EYE RESEARCH

Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells

(2009) Katrien De Bock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cells

(2009) Michael H. Davies et al.   MICROVASCULAR RESEARCH

Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation

(2008) Eric Ispanovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Retardation of Retinal Vascular Development in Apelin-Deficient Mice

(2008) Atsushi Kasai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126

(2008) F. Kuhnert et al.   DEVELOPMENT

miR-126 Regulates Angiogenic Signaling and Vascular Integrity

(2008) Jason E. Fish et al.   DEVELOPMENTAL CELL

MicroRNAs Regulate Ocular Neovascularization

(2008) JiKui Shen et al.   MOLECULAR THERAPY

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE

The Angio-Fibrotic Switch of VEGF and CTGF in Proliferative Diabetic Retinopathy

(2008) Esther J. Kuiper et al.   PLoS One

Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors

(2008) Magali Saint-Geniez et al.   PLoS One

Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

(2007) Laura S. Harrington et al.   MICROVASCULAR RESEARCH