Saikosaponin D: A potential therapeutic drug for osteoarthritis

Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway

(2019) Li-Hua Cui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

(2019) Zhenhan Deng et al.   BIOSCIENCE REPORTS

Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression

(2019) Lixing Xu et al.   NEUROPHARMACOLOGY

Saikosaponin-d Suppresses COX2 Through p-STAT3/C/EBPβ Signaling Pathway in Liver Cancer: A Novel Mechanism of Action

(2019) Mudan Ren et al.   Frontiers in Pharmacology

Juglanin inhibits IL-1β-induced inflammation in human chondrocytes

(2019) Xinxin Chen et al.   Artificial Cells Nanomedicine and Biotechnology

Inducible nitric oxide synthase as a target for osteoarthritis treatment

(2018) Andreas Leonidou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit

(2018) Veronica Macchi et al.   JOURNAL OF ANATOMY

ADAMTS proteins in human disorders

(2018) Timothy J. Mead et al.   MATRIX BIOLOGY

Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ–AMPK–mTOR pathway in ADPKD cells

(2018) Weiwei Shi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

(2018) Jisheng Ran et al.   Drug Design Development and Therapy

Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

(2018) Ching-Hou Ma et al.   Redox Biology

Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling

(2018) Jixia Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning

(2018) Na Lu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation

(2018) Gang Zheng et al.   Cell Death & Disease

Effects of Saikosaponin D on apoptosis in human U87 glioblastoma cells

(2017) Yan Li et al.   Molecular Medicine Reports

Beclin 1 overexpression inhibits chondrocyte apoptosis and downregulates extracellular matrix metabolism in osteoarthritis

(2017) Bin Song et al.   Molecular Medicine Reports

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

(2017) C.-Y. Yang et al.   OSTEOARTHRITIS AND CARTILAGE

Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis

(2017) Hong-Yan Li et al.   PSYCHOPHARMACOLOGY

Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest

(2017) Hideaki Tsuyoshi et al.   Oncotarget

Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models

(2017) Shan-Chi Liu et al.   Scientific Reports

Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy

(2017) Fei Xu et al.   Scientific Reports

Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies

(2017) Yuxin Zhang et al.   Scientific Reports

mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3

(2017) Yanli Liu et al.   Scientific Reports

The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy

(2016) Ni-Tao Cheng et al.   BMC MUSCULOSKELETAL DISORDERS

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

(2016) Maryam Rahmati et al.   BONE

Sucrose, But Not Glucose, Blocks IL1-β-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway

(2016) Nazir M. Khan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of autophagy by Beclin 1 in the heart

(2016) Yasuhiro Maejima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lycorine protects cartilage through suppressing the expression of matrix metalloprotenases in rat chondrocytes and in a mouse osteoarthritis model

(2016) Shuai Chen et al.   Molecular Medicine Reports

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Characterization of synovial mast cells in knee osteoarthritis: association with clinical parameters

(2016) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis

(2016) Kok-Yong Chin   Drug Design Development and Therapy

Autophagy gene expression profiling identifies a defective microtubule-associated protein light chain 3A mutant in cancer

(2016) Joana R. Costa et al.   Oncotarget

Review: Metabolic Regulation of Inflammation in Osteoarthritis

(2016) Francis Berenbaum et al.   Arthritis & Rheumatology

Cancer statistics: Breast cancer in situ

(2015) Elizabeth M. Ward et al.   CA-A CANCER JOURNAL FOR CLINICIANS

p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration

(2015) Michelle E Turvey et al.   IMMUNOLOGY AND CELL BIOLOGY

Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways

(2015) Xiaobin Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma

(2015) LIANG CHANG et al.   Molecular Medicine Reports

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

(2015) Guowu Hu et al.   NATURE CELL BIOLOGY

Inflammation and intracellular metabolism: new targets in OA

(2015) R. Liu-Bryan   OSTEOARTHRITIS AND CARTILAGE

Socio-economic costs of osteoarthritis: A systematic review of cost-of-illness studies

(2015) Jaume Puig-Junoy et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Clinical effectiveness and micro-perfusion alteration of Jingui external lotion in patients with knee osteoarthritis: study protocol for a randomized controlled trial

(2015) Da Guo et al.   Trials

mTOR pathway in colorectal cancer: an update

(2015) Maria Giovanna Francipane et al.   Oncotarget

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

mTOR inhibitors and their clinical application in cervical, endometrial and ovarian cancers: A critical review

(2014) Nader Husseinzadeh et al.   GYNECOLOGIC ONCOLOGY

Nerve Growth Factor (NGF) Regulates Activity of Nuclear Factor of Activated T-cells (NFAT) in Neurons via the Phosphatidylinositol 3-Kinase (PI3K)-Akt-Glycogen Synthase Kinase 3β (GSK3β) Pathway

(2014) Man-Su Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity

(2014) Jiahong Lu et al.   Nature Communications

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

(2014) Nicole C. McKnight et al.   PLoS Genetics

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Increased osteoblast and osteoclast indices in individuals with systemic mastocytosis

(2013) S. Seitz et al.   OSTEOPOROSIS INTERNATIONAL

Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells

(2013) V KW Wong et al.   Cell Death & Disease

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway

(2012) Chun-Ni Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology