Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE

Latent Phase Identification of High-Frequency Micro-Scale Gamma Spike Transients in the Hypoxic Ischemic EEG of Preterm Fetal Sheep Using Spectral Analysis and Fuzzy Classifiers

(2020) Hamid Abbasi et al.   SENSORS

Csf1 Deficiency Dysregulates Glial Responses to Demyelination and Disturbs CNS White Matter Remyelination

(2020) Bartosz Wylot et al.   Cells

Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice

(2020) Shunichiro Tsuji et al.   Journal of Neuroinflammation

Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy

(2020) Charlotte Rawlinson et al.   Brain Sciences

MicroRNA-374a-5p inhibits neuroinflammation in neonatal hypoxic-ischemic encephalopathy via regulating NLRP3 inflammasome targeted Smad6

(2020) Zhong Chen et al.   LIFE SCIENCES

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

(2019) Andrew G. Horti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE

(2019) Agnieszka Wlodarczyk et al.   Frontiers in Cellular Neuroscience

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

(2019) Lorenza Magno et al.   Alzheimers Research & Therapy

Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia–Ischemia: Potential Mechanism of Action

(2019) Joanna Jaworska et al.   MOLECULAR NEUROBIOLOGY

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

(2019) Sven J. van der Lee et al.   ACTA NEUROPATHOLOGICA

Overexpression and activation of colony‐stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroHIV

(2019) Derek L. Irons et al.   BRAIN PATHOLOGY

Intranasal Delivery of Mesenchymal Stromal Cells Protects against Neonatal Hypoxic–Ischemic Brain Injury

(2019) Courtney A. McDonald et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review

(2019) Fabian Herold et al.   European Review of Aging and Physical Activity

Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke

(2019) Yuan Zhang et al.   Translational Stroke Research

Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology

(2019) Amin Derouiche et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia: Same same, but different

(2019) Katrin Kierdorf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PKCγ and PKCε are Differentially Activated and Modulate Neurotoxic Signaling Pathways During Oxygen Glucose Deprivation in Rat Cortical Slices

(2019) Dayana Surendran   NEUROCHEMICAL RESEARCH

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

(2019) Courtney Easley-Neal et al.   Frontiers in Immunology

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

(2019) WeiYu Lin et al.   Frontiers in Immunology

Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan

(2019) Kuo-Hsuan Chang et al.   Journal of Clinical Medicine

Activation of TGR5 with INT-777 attenuates oxidative stress and neuronal apoptosis via cAMP/PKCε/ALDH2 pathway after subarachnoid hemorrhage in rats

(2019) Gang Zuo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Two-Year Neurodevelopmental Outcomes After Mild Hypoxic Ischemic Encephalopathy in the Era of Therapeutic Hypothermia

(2019) Mikael Finder et al.   JAMA Pediatrics

Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway

(2019) Xin Guan et al.   Frontiers in Pharmacology

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

(2019) Matthew L. Neal et al.   FASEB JOURNAL

Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system

(2019) Zhiguang Wu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

(2018) Fengna Chu et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased Microglial CSF1R Expression in the SIV/Macaque Model of HIV CNS Disease

(2018) Audrey C Knight et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats

(2018) Motoki Tanaka et al.   Translational Stroke Research

PAI-1 but Not PAI-2 Gene Deficiency Attenuates Ischemic Brain Injury After Experimental Stroke

(2018) Eva-Verena Griemert et al.   Translational Stroke Research

Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy

(2018) Tamara I. Herrera et al.   EARLY HUMAN DEVELOPMENT

Thyroxin Protects White Matter from Hypoxic-Ischemic Insult in the Immature Sprague–Dawley Rat Brain by Regulating Periventricular White Matter and Cortex BDNF and CREB Pathways

(2018) Pi-Lien Hung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

(2018) Nynke Oosterhof et al.   Cell Reports

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration

(2018) Varun Kumar et al.   BMC NEUROSCIENCE

ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

(2018) Olivia J Conway et al.   Molecular Neurodegeneration

Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy

(2018) Abdullah Al Mamun et al.   NEUROCHEMISTRY INTERNATIONAL

Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury

(2018) Hongwei Liu et al.   Translational Stroke Research

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Neuroprotective effect of licochalcone A against oxygen-glucose deprivation/reperfusion in rat primary cortical neurons by attenuating oxidative stress injury and inflammatory response via the SIRT1/Nrf2 pathway

(2017) Xiaohong Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Selective proliferative response of microglia to alternative polarization signals

(2017) Giovanna Pepe et al.   Journal of Neuroinflammation

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

(2017) Douglas G. Walker et al.   Frontiers in Aging Neuroscience

Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury

(2017) Zhong Wang et al.   Translational Stroke Research

The activation of μ-opioid receptor potentiates LPS-induced NF-kB promoting an inflammatory phenotype in microglia

(2016) Stefania Gessi et al.   FEBS LETTERS

Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis

(2016) Nozha Borjini et al.   Journal of Neuroinflammation

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Store-Operated Ca2+ Entry (SOCE) and Purinergic Receptor-Mediated Ca2+ Homeostasis in Murine bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation

(2016) Daniel F. Gilbert et al.   Frontiers in Molecular Neuroscience

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

(2015) Sandrine Obba et al.   Autophagy

PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

(2015) Hayley Mylroie et al.   CARDIOVASCULAR RESEARCH

Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats

(2015) Ya Miao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

(2015) Qifang Xu et al.   Science Signaling

DNA Methylation Inhibitor Zebularine Confers Stroke Protection in Ischemic Rats

(2015) Hua Dock et al.   Translational Stroke Research

Hypoxic-Ischemic Encephalopathy

(2015) Martha Douglas-Escobar et al.   JAMA Pediatrics

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

(2015) Qifang Xu et al.   Science Signaling

Protein kinase C (PKC) mediated interaction between conexin43 (Cx43) and K+(ATP) channel subunit (Kir6.1) in cardiomyocyte mitochondria: Implications in cytoprotection against hypoxia induced cell apoptosis

(2014) Ajaz Ahmad Waza et al.   CELLULAR SIGNALLING

CSF1 overexpression has pleiotropic effects on microgliain vivo

(2014) Ishani De et al.   GLIA

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

PLCγ2 and PKC Are Important to Myeloid Lineage Commitment Triggered by M-SCF and G-CSF

(2013) Christiano Marcello Vaz Barbosa et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics