Csf1 Deficiency Dysregulates Glial Responses to Demyelination and Disturbs CNS White Matter Remyelination

Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model

(2019) Fatemeh Tahmasebi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

(2019) Marlijn van der Poel et al.   Nature Communications

Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia

(2019) Nynke Oosterhof et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CSF-1 controls cerebellar microglia and is required for motor function and social interaction

(2019) Veronika Kana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting microglia in brain disorders

(2019) Josef Priller et al.   SCIENCE

Microglial subtypes: diversity within the microglial community

(2019) Vassilis Stratoulias et al.   EMBO JOURNAL

Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo

(2019) Yiting Liu et al.   EXPERIMENTAL NEUROLOGY

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

(2019) Courtney Easley-Neal et al.   Frontiers in Immunology

Myeloid cell plasticity in the evolution of central nervous system autoimmunity

(2018) David A. Giles et al.   ANNALS OF NEUROLOGY

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

Increased expression of colony-stimulating factor-1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss

(2018) Svetlana Gushchina et al.   GLIA

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

(2018) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells

(2018) Justyna Ulanska-Poutanen et al.   eLife

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

An updated assessment of microglia depletion: current concepts and future directions

(2017) Jinming Han et al.   Molecular Brain

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

(2016) Feng Mei et al.   eLife

Adapting brain metabolism to myelination and long-range signal transduction

(2014) Johannes Hirrlinger et al.   GLIA

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

The role of myelin and oligodendrocytes in axonal energy metabolism

(2013) Aiman S Saab et al.   CURRENT OPINION IN NEUROBIOLOGY

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response

(2013) Malgorzata Sielska et al.   JOURNAL OF PATHOLOGY

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

Oligodendroglia: metabolic supporters of axons

(2013) Brett M. Morrison et al.   TRENDS IN CELL BIOLOGY

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Axonal Damage in Multiple Sclerosis

(2011) Jeffery D. Haines et al.   MOUNT SINAI JOURNAL OF MEDICINE

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Wallerian Degeneration: A Major Component of Early Axonal Pathology in Multiple Sclerosis

(2010) Tomasz Dziedzic et al.   BRAIN PATHOLOGY

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia

(2010) Deanna L. Taylor et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

Selective reduction in microglia density and function in the white matter of colony-stimulating factor-1-deficient mice

(2009) Yoichi Kondo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Phosphorylation and compactness of neurofilaments in multiple sclerosis: Indicators of axonal pathology

(2008) Axel Petzold et al.   EXPERIMENTAL NEUROLOGY

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE