Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood–Brain Barrier Integrity in Stroke

Roles of Pericytes in Stroke Pathogenesis

(2018) Jyoti Gautam et al.   CELL TRANSPLANTATION

Sigma-1 receptor activation alleviates blood-brain barrier dysfunction in vascular dementia mice

(2018) Dan-Yang Liu et al.   EXPERIMENTAL NEUROLOGY

Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving cerebral perfusion and restoring functional loss after stroke in aged rats

(2018) Yi-Fan Zhou et al.   NEUROBIOLOGY OF AGING

Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke

(2018) Ilknur Özen et al.   STROKE

An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke

(2017) Xiaotian Zhang et al.   Journal of Stroke & Cerebrovascular Diseases

The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9

(2017) Pilar Sánchez-Blázquez et al.   MOLECULAR NEUROBIOLOGY

Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress

(2017) Nino Goguadze et al.   NEUROTOXICITY RESEARCH

An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke

(2017) Xiaotian Zhang et al.   Journal of Stroke & Cerebrovascular Diseases

Neuroprotection of Ro25-6981 Against Ischemia/Reperfusion-Induced Brain Injury via Inhibition of Autophagy

(2016) Fuxing Dong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Survival or death: a dual role for autophagy in stress-induced pericyte loss in diabetic retinopathy

(2016) Dongxu Fu et al.   DIABETOLOGIA

The VWF-GPIb axis in ischaemic stroke: lessons from animal models

(2016) Frederik Denorme et al.   THROMBOSIS AND HAEMOSTASIS

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

Electroacupuncture pretreatment induces tolerance against cerebral ischemia/reperfusion injury through inhibition of the autophagy pathway

(2015) ZHOUQUAN WU et al.   Molecular Medicine Reports

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke

(2015) Sandra A. Acosta et al.   STROKE

Possible involvement of the sigma-1 receptor chaperone in chemotherapeutic-induced neuropathic pain

(2015) Mori Tomohisa et al.   SYNAPSE

Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke

(2015) Ying Bai et al.   PLoS One

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

(2014) Veronica Francardo et al.   BRAIN

Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice

(2014) Shigeki Moriguchi et al.   MOLECULAR NEUROBIOLOGY

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Phase II Trial of the Sigma-1 Receptor Agonist Cutamesine (SA4503) for Recovery Enhancement After Acute Ischemic Stroke

(2014) Roman Urfer et al.   STROKE

All’s well that transcribes well: Non-coding RNAs and post-stroke brain damage

(2013) Raghu Vemuganti   NEUROCHEMISTRY INTERNATIONAL

Novel Protective Effects of Histone Deacetylase Inhibition on Stroke and White Matter Ischemic Injury

(2013) Selva Baltan et al.   Neurotherapeutics

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke

(2012) Francisco Fernández-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of the Sigma-1 Receptor Agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-Phenylpropyl)-Piperazine Dihydro-Chloride on Inflammation after Stroke

(2012) Karsten Ruscher et al.   PLoS One

The sigma-1 receptor: roles in neuronal plasticity and disease

(2012) Saïd Kourrich et al.   TRENDS IN NEUROSCIENCES

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

(2011) Karsten Ruscher et al.   BRAIN

Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats

(2011) Mohammad Allahtavakoli et al.   BRAIN RESEARCH BULLETIN

Cocaine Hijacks  1 Receptor to Initiate Induction of Activated Leukocyte Cell Adhesion Molecule: Implication for Increased Monocyte Adhesion and Migration in the CNS

(2011) H. Yao et al.   JOURNAL OF NEUROSCIENCE

Activation of the sigma receptor 1 suppresses NMDA responses in rat retinal ganglion cells

(2011) X.-J. Zhang et al.   NEUROSCIENCE

 1 Receptor Modulation of G-Protein-Coupled Receptor Signaling: Potentiation of Opioid Transduction Independent from Receptor Binding

(2010) F. J. Kim et al.   MOLECULAR PHARMACOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Sigma receptors suppress multiple aspects of microglial activation

(2008) Aaron A. Hall et al.   GLIA

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL