Back to the plant: overcoming roadblocks to the microbial production of pharmaceutically important plant natural products

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids

(2020) Michael E. Pyne et al.   Nature Communications

Engineering Plant Secondary Metabolism in Microbial Systems

(2019) Michael E Pyne et al.   PLANT PHYSIOLOGY

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy

(2019) Mehran Dastmalchi et al.   Nature Chemical Biology

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

(2019) Xiaozhou Luo et al.   NATURE

Synthetic biology strategies for microbial biosynthesis of plant natural products

(2019) Aaron Cravens et al.   Nature Communications

Cannabis glandular trichomes alter morphology and metabolite content during flower maturation

(2019) S. J. Livingston et al.   PLANT JOURNAL

Purine permease-type benzylisoquinoline alkaloid transporters in opium poppy

(2019) Mehran Dastmalchi et al.   PLANT PHYSIOLOGY

Structure–function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition

(2019) Dean E. Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benzylisoquinoline alkaloid biosynthesis in opium poppy: an update

(2019) Aparna Singh et al.   PHYTOCHEMISTRY REVIEWS

Structure and Biocatalytic Scope of Coclaurine N -Methyltransferase

(2018) Matthew R. Bennett et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

(2018) Emanuela Martino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway

(2018) Anna Kluza et al.   JOURNAL OF STRUCTURAL BIOLOGY

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

(2018) Xue Chen et al.   Nature Chemical Biology

Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy

(2018) Mehran Dastmalchi et al.   PLANT JOURNAL

Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine

(2018) Yang Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete biosynthesis of noscapine and halogenated alkaloids in yeast

(2018) Yanran Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

(2018) Lorenzo Caputi et al.   SCIENCE

Industrial brewing yeast engineered for the production of primary flavor determinants in hopped beer

(2018) Charles M. Denby et al.   Nature Communications

Microbial production of novel sulphated alkaloids for drug discovery

(2018) Eitaro Matsumura et al.   Scientific Reports

Completion of the canonical pathway for assembly of anticancer drugs vincristine/vinblastine in Catharanthus roseus

(2018) Yang Qu et al.   PLANT JOURNAL

A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci

(2018) Kaitlin U. Laverty et al.   GENOME RESEARCH

Engineering yeasts as platform organisms for cannabinoid biosynthesis

(2017) Bastian Zirpel et al.   JOURNAL OF BIOTECHNOLOGY

Identification of Iridoid Glucoside Transporters in Catharanthus roseus

(2017) Bo Larsen et al.   PLANT AND CELL PHYSIOLOGY

Geissoschizine synthase controls flux in the formation of monoterpenoid indole alkaloids in a Catharanthus roseus mutant

(2017) Yang Qu et al.   PLANTA

Laboratory-scale production of (S)-reticuline, an important intermediate of benzylisoquinoline alkaloids, using a bacterial-based method

(2016) Eitaro Matsumura et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Plant ABC Transporters Enable Many Unique Aspects of a Terrestrial Plant's Lifestyle

(2016) Jae-Ung Hwang et al.   Molecular Plant

Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

(2016) Akira Nakagawa et al.   Nature Communications

Engineering of a Nepetalactol-Producing Platform Strain of Saccharomyces cerevisiae for the Production of Plant Seco-Iridoids

(2016) Alex Campbell et al.   ACS Synthetic Biology

Cannabis sativa: The Plant of the Thousand and One Molecules

(2016) Christelle M. Andre et al.   Frontiers in Plant Science

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome

(2015) Thomas Dugé de Bernonville et al.   BMC GENOMICS

De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast

(2015) Isis J. Trenchard et al.   METABOLIC ENGINEERING

Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family

(2015) Jennifer Munkert et al.   Molecular Plant

Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

(2015) Scott C Farrow et al.   Nature Chemical Biology

An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

(2015) William C DeLoache et al.   Nature Chemical Biology

Genome-guided investigation of plant natural product biosynthesis

(2015) Franziska Kellner et al.   PLANT JOURNAL

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

(2015) Yang Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

(2015) T. Winzer et al.   SCIENCE

Complete biosynthesis of opioids in yeast

(2015) S. Galanie et al.   SCIENCE

A microbial biomanufacturing platform for natural and semisynthetic opioids

(2014) Kate Thodey et al.   Nature Chemical Biology

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae

(2014) Elena Fossati et al.   Nature Communications

(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli

(2014) Akira Nakagawa et al.   Scientific Reports

Improvement of Reticuline Productivity from Dopamine by Using EngineeredEscherichia coli

(2013) Ju-Sung KIM et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

A Pair of Tabersonine 16-Hydroxylases Initiates the Synthesis of Vindoline in an Organ-Dependent Manner in Catharanthus roseus

(2013) S. Besseau et al.   PLANT PHYSIOLOGY

ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus

(2013) F. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redesign of a Dioxygenase in Morphine Biosynthesis

(2012) Weerawat Runguphan et al.   CHEMISTRY & BIOLOGY

Structure and Function of ∆1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabis sativa

(2012) Yoshinari Shoyama et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides

(2012) S. J. Gagne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

(2010) Jillian M Hagel et al.   Nature Chemical Biology

Norcoclaurine Synthase Is a Member of the Pathogenesis-Related 10/Bet v1 Protein Family

(2010) Eun-Jeong Lee et al.   PLANT CELL

Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway

(2009) Futoshi Taura et al.   FEBS LETTERS

CYP719B1 Is Salutaridine Synthase, the C-C Phenol-coupling Enzyme of Morphine Biosynthesis in Opium Poppy

(2009) Andreas Gesell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Halogenation Strategies In Natural Product Biosynthesis

(2008) Christopher S. Neumann et al.   CHEMISTRY & BIOLOGY

Alleviation of feedback inhibition in Saccharomyces cerevisiae aromatic amino acid biosynthesis: Quantification of metabolic impact

(2008) M.A.H. Luttik et al.   METABOLIC ENGINEERING

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA