The role of the CD39–CD73–adenosine pathway in liver disease

CD73 sustained cancer-stem-cell traits by promoting SOX9 expression and stability in hepatocellular carcinoma

(2020) Xiao-Lu Ma et al.   Journal of Hematology & Oncology

CD73 expression in normal and pathological human hepatobiliopancreatic tissues

(2019) Amedeo Sciarra et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

(2019) Xiao-Lu Ma et al.   Journal of Hematology & Oncology

Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis

(2019) Sonja Rothweiler et al.   Purinergic Signalling

HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape

(2019) Qiuju Han et al.   Cells

Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma

(2019) Zeli Yin et al.   Journal of Hematology & Oncology

Targeting adenosinergic pathway enhances the anti-tumor efficacy of sorafenib in hepatocellular carcinoma

(2019) Jing Liao et al.   Hepatology International

Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH

(2019) Jing Zhou et al.   JOURNAL OF ENDOCRINOLOGY

Extracellular adenosine reversibly inhibits the activation of human regulatory T cells and negatively influences the achievement of the operational tolerance in liver transplantation

(2018) Alberto Baroja-Mazo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Interleukin 2 promotes hepatic regulatory T cell responses and protects from biliary fibrosis in murine sclerosing cholangitis

(2018) Amy E. Taylor et al.   HEPATOLOGY

Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

(2018) Yuli Cai et al.   HEPATOLOGY

Targeting the CD73-adenosine axis in immuno-oncology

(2018) David Allard et al.   IMMUNOLOGY LETTERS

Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway

(2018) Xueran Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hepatocellular carcinoma in Gaucher disease: an international case series

(2018) Martine Regenboog et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance

(2018) Maxim Durand et al.   KIDNEY INTERNATIONAL

Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening

(2018) Patrick Marcellin et al.   LIVER INTERNATIONAL

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

(2018) Konstantin Knoblich et al.   PLOS BIOLOGY

Fine needle aspirates comprehensively sample intrahepatic immunity

(2018) Upkar S Gill et al.   GUT

Ecto-5′-nucleotidase (CD73) is a potential target of hepatocellular carcinoma

(2018) Shalaimaiti Shali et al.   JOURNAL OF CELLULAR PHYSIOLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibiting Adenosine Receptor Signaling Promotes Accumulation of Effector CD4+ T Cells in the Lung Parenchyma During Severe Tuberculosis

(2018) Eduardo Pinheiro Amaral et al.   JOURNAL OF INFECTIOUS DISEASES

Host Regulators of Liver Fibrosis During Human Schistosomiasis

(2018) Severin Donald Kamdem et al.   Frontiers in Immunology

Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice

(2017) Michitaka Matsuda et al.   HEPATOLOGY

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

(2017) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury

(2017) Luiz Eduardo Baggio Savio et al.   JOURNAL OF HEPATOLOGY

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

(2017) Kenneth A. Jacobson et al.   MEDICINAL RESEARCH REVIEWS

Extracellular ATP and adenosine: The Yin and Yang in immune responses?

(2017) M.M. Faas et al.   MOLECULAR ASPECTS OF MEDICINE

Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

(2017) Si-Rui Ma et al.   Molecular Cancer

Regulatory T cell frequencies and phenotypes following anti-viral vaccination

(2017) A. Charlotte M. T. de Wolf et al.   PLoS One

Immune Regulation by T Regulatory Cells in Hepatitis B Virus-Related Inflammation and Cancer

(2017) N. Trehanpati et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure

(2017) Eunyoung Tak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity

(2017) Elisa Alchera et al.   Translational Research

Clinical significance of changes in the Th17/Treg ratio in autoimmune liver disease

(2017) Ting-Ting Feng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis

(2017) Murat Torgutalp et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Adenosine: Direct and Indirect Actions on Gastric Acid Secretion

(2017) Rosa M. Arin et al.   Frontiers in Physiology

What Else Can CD39 Tell Us?

(2017) Hai Zhao et al.   Frontiers in Immunology

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer

(2017) Jieyao Li et al.   OncoImmunology

The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin

(2017) Jessica L. Feig et al.   PLoS One

Overexpression of interleukin-35 associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection

(2016) Yi-Peng Fu et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

(2016) Jian Gu et al.   Cellular & Molecular Immunology

Purinergic signaling in scarring

(2016) Davide Ferrari et al.   FASEB JOURNAL

Protective Effects of Adenosine Receptor Agonist in a Cirrhotic Liver Resection Model

(2016) Emil Iskandarov et al.   Hepatitis Monthly

Dynamic changes in CD45RA−Foxp3high regulatory T-cells in chronic hepatitis C patients during antiviral therapy

(2016) Zhiqin Li et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease

(2016) Rodrigo Liberal et al.   JOURNAL OF AUTOIMMUNITY

Hepatitis C-specific effector and regulatory CD4 T-cell responses are associated with the outcomes of primary infection

(2016) E. Keoshkerian et al.   JOURNAL OF VIRAL HEPATITIS

Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection

(2016) Xiao-Yan Cai et al.   MEDICINE

Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs

(2015) Yaru Yang et al.   BIOCHIMIE

CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression

(2015) María Rosa Bono et al.   FEBS LETTERS

Rapid activation and hepatic recruitment of innate-like regulatory B cells after invariant NKT cell stimulation in mice

(2015) Wagdi Almishri et al.   JOURNAL OF HEPATOLOGY

CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection

(2015) Osamu Yoshida et al.   TRANSPLANT IMMUNOLOGY

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

Extracellular adenosine controls NKT-cell-dependent hepatitis induction

(2014) Meenakshi Subramanian et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The global burden of liver disease: The major impact of China

(2014) Fu-Sheng Wang et al.   HEPATOLOGY

Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway

(2014) Rongjia Zhang et al.   JOURNAL OF HEPATOLOGY

Restoration of Adenosine Deaminase-Deficient Human Thymocyte Development In Vitro by Inhibition of Deoxynucleoside Kinases

(2014) M. L. Joachims et al.   JOURNAL OF IMMUNOLOGY

Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5′-nucleotidase (CD73)

(2014) Natasha T. Snider et al.   MOLECULAR BIOLOGY OF THE CELL

Caffeine Inhibits the Activation of Hepatic Stellate Cells Induced by Acetaldehyde via Adenosine A2A Receptor Mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK Signal Pathway

(2014) He Wang et al.   PLoS One

Study of liver cirrhosis over ten consecutive years in Southern China

(2014) Xing Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatitis C virus infection in patients with HIV-1: epidemiology, natural history and management

(2014) Wen Kang et al.   Expert Review of Gastroenterology & Hepatology

Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

(2014) J. Bastid et al.   Cancer Immunology Research

Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb

(2014) Md. Kaimul Ahsan et al.   Frontiers in Pharmacology

The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation

(2014) Veena Roberts et al.   Frontiers in Immunology

CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice

(2013) Osamu Yoshida et al.   HEPATOLOGY

CD73 (ecto-5′-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation

(2013) Natasha T. Snider et al.   HEPATOLOGY

Dysfunctional CD39POSregulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis

(2013) Charlotte R. Grant et al.   HEPATOLOGY

Suppressive activity and altered conventional phenotype markers/mediators of regulatory T cells in patients with self-limiting hepatitis E

(2013) S. B. Rathod et al.   JOURNAL OF VIRAL HEPATITIS

ADORA2B helps to block liver injury

(2013) Katherine Smith   Nature Reviews Gastroenterology & Hepatology

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas

(2013) Shuo Xu et al.   NEURO-ONCOLOGY

Purinergic Signaling during Inflammation

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study

(2013) S. M. Stemmer et al.   ONCOLOGIST

Adenosine 2A Receptor Antagonist Prevented and Reversed Liver Fibrosis in a Mouse Model of Ethanol-Exacerbated Liver Fibrosis

(2013) Dian J. Chiang et al.   PLoS One

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

(2013) Fenila Jacob et al.   Purinergic Signalling

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

(2013) Edwin SL Chan et al.   ARTHRITIS RESEARCH & THERAPY

Activated hepatic stellate cells upregulate transcription of ecto-5′-nucleotidase/CD73 via specific SP1 and SMAD promoter elements

(2012) Michel Fausther et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CD39 Modulates Hematopoietic Stem Cell Recruitment and Promotes Liver Regeneration in Mice and Humans After Partial Hepatectomy

(2012) Moritz Schmelzle et al.   ANNALS OF SURGERY

Regulation of Macrophage Function by Adenosine

(2012) György Haskó et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Lymphocyte Function by Adenosine

(2012) Joel Linden et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection

(2012) Yan Tang et al.   BMC IMMUNOLOGY

CD73 and adenosine generation in the creation of regulatory microenvironments

(2012) F. S. Regateiro et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Adenosine A2areceptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats

(2012) Chiara Imarisio et al.   CLINICAL SCIENCE

CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease

(2012) Glen A. Doherty et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Purinergic P2Y2 Receptors Promote Neutrophil Infiltration and Hepatocyte Death in Mice With Acute Liver Injury

(2012) Cemil Korcan Ayata et al.   GASTROENTEROLOGY

Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+T cells

(2012) Sandra Pommey et al.   HEPATOLOGY

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice

(2012) Xiaofeng Sun et al.   HEPATOLOGY

ENTPD1/CD39 is a promising therapeutic target in oncology

(2012) J Bastid et al.   ONCOGENE

The CD39-adenosinergic axis in the pathogenesis of renal ischemia–reperfusion injury

(2012) Veena Roberts et al.   Purinergic Signalling

In Vivo Hypoxic Preconditioning Protects From Warm Liver Ischemia-Reperfusion Injury Through the Adenosine A2B Receptor

(2012) Alexander Choukèr et al.   TRANSPLANTATION

Coexpression of ecto-5′-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver

(2011) Michel Fausther et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ecto-5′-nucleotidase/CD73 knockdown increases cell migration and mRNA level of collagen I in a hepatic stellate cell line

(2011) Cláudia M. B. Andrade et al.   CELL AND TISSUE RESEARCH

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Identification of circulating CD90+CD73+cells in cirrhosis of liver

(2011) Mitnala Sasikala   World Journal of Stem Cells

CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice

(2010) Xiaofeng Sun et al.   GASTROENTEROLOGY

CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

(2010) S. Cohen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

Activation of Adenosine A2A Receptor Attenuates Inflammatory Response in a Rat Model of Small-for-Size Liver Transplantation

(2010) L.-M. Tang et al.   TRANSPLANTATION PROCEEDINGS

A Contradictory Role of A1 Adenosine Receptor in Carbon Tetrachloride- and Bile Duct Ligation-Induced Liver Fibrosis in Mice

(2009) P. Yang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Extracellular Adenosine Production by Ecto-5′-Nucleotidase Protects During Murine Hepatic Ischemic Preconditioning

(2008) Melanie L. Hart et al.   GASTROENTEROLOGY

Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice

(2008) Jeehee Kim et al.   LIVER TRANSPLANTATION

Activity and expression of ecto-5′-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line

(2007) Cláudia M.B. Andrade et al.   LIFE SCIENCES