Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis

(2016) Katarzyna M. Luda et al.   IMMUNITY

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Guardians of the Gut – Murine Intestinal Macrophages and Dendritic Cells

(2015) Mor Gross et al.   Frontiers in Immunology

Increased Production of Retinoic Acid by Intestinal Macrophages Contributes to Their Inflammatory Phenotype in Patients With Crohn's Disease

(2014) Theodore J. Sanders et al.   GASTROENTEROLOGY

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

(2014) Yuko Yoshida et al.   IMMUNITY

Intestinal dendritic cells in the regulation of mucosal immunity

(2014) Vasileios Bekiaris et al.   IMMUNOLOGICAL REVIEWS

Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease

(2014) S. Minagawa et al.   Science Translational Medicine

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

(2013) John J. Worthington et al.   PLoS Pathogens

A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells

(2012) A. N. McMurchy et al.   BLOOD

Preferential Expression of Integrin αvβ8 Promotes Generation of Regulatory T Cells by Mouse CD103+ Dendritic Cells

(2011) Helena Païdassi et al.   GASTROENTEROLOGY

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

IRF8Mutations and Human Dendritic-Cell Immunodeficiency

(2011) Sophie Hambleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcription of the Transforming Growth Factor β Activating Integrin β8 Subunit Is Regulated by SP3, AP-1, and the p38 Pathway

(2010) Jennifer A. Markovics et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice

(2010) Andrew C. Melton et al.   JOURNAL OF CLINICAL INVESTIGATION

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mice that lack activity of  v 6- and  v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

(2009) P. Aluwihare et al.   JOURNAL OF CELL SCIENCE

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY