Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression

Dichotomous roles of TGF-β in human cancer

(2016) Jennifer J. Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The complexity of integrins in cancer and new scopes for therapeutic targeting

(2016) Hellyeh Hamidi et al.   BRITISH JOURNAL OF CANCER

The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma

(2016) Mujeeburahiman Cheerathodi et al.   MOLECULAR CANCER RESEARCH

Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations

(2016) Efthimios Dardiotis et al.   NEUROMOLECULAR MEDICINE

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma

(2016) Xiao-Yan Ming et al.   Nature Communications

Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice

(2016) Li Ma et al.   Translational Stroke Research

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells

(2016) Boyoung Wee et al.   Scientific Reports

Neuropilin 1 balances  8 integrin-activated TGF  signaling to control sprouting angiogenesis in the brain

(2015) S. Hirota et al.   DEVELOPMENT

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact

(2015) P. Sathyan et al.   JOURNAL OF NEUROSCIENCE

Protein Tyrosine Phosphatase-PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells

(2015) Hye Shin Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

(2015) Shyam Nyati et al.   Science Signaling

Transforming growth factor-β pathway activity in glioblastoma

(2015) Karl Frei et al.   Oncotarget

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells

(2015) Chad M. Toledo et al.   Cell Reports

The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

(2015) Shyam Nyati et al.   Science Signaling

Antiangiogenic Therapy for Glioblastoma: Current Status and Future Prospects

(2014) T. T. Batchelor et al.   CLINICAL CANCER RESEARCH

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking  V 8-TGF  signaling in the brain

(2014) T. D. Arnold et al.   DEVELOPMENT

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Gene Expression Profile Identifies Tyrosine Kinase c-Met as a Targetable Mediator of Antiangiogenic Therapy Resistance

(2013) A. Jahangiri et al.   CLINICAL CANCER RESEARCH

Glioblastoma Resistance to Anti-VEGF Therapy: Has the Challenge Been MET?

(2013) J. H. McCarty   CLINICAL CANCER RESEARCH

Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition

(2013) Y. Piao et al.   CLINICAL CANCER RESEARCH

Current status of antiangiogenic therapies for glioblastomas

(2013) Isabel Arrillaga-Romany et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion

(2013) Steve B. Reyes et al.   MOLECULAR BIOLOGY OF THE CELL

 v Integrins in Angiogenesis and Cancer

(2013) S. M. Weis et al.   Cold Spring Harbor Perspectives in Medicine

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis

(2012) Meena Upadhyaya et al.   HUMAN MUTATION

Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin  V 8-Mediated Activation of Transforming Growth Factor- 

(2012) T. D. Arnold et al.   JOURNAL OF NEUROSCIENCE

Endothelial Expression of TGFβ Type II Receptor Is Required to Maintain Vascular Integrity during Postnatal Development of the Central Nervous System

(2012) Kathleen R. Allinson et al.   PLoS One

Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells

(2012) Yu Ding et al.   Cancer Discovery

Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by  8 Integrin

(2011) J. H. Tchaicha et al.   CANCER RESEARCH

The astrocyte-expressed integrin  v 8 governs blood vessel sprouting in the developing retina

(2011) S. Hirota et al.   DEVELOPMENT

β8 integrin is essential for neuroblast migration in the rostral migratory stream

(2011) Aaron K. Mobley et al.   GLIA

Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery

(2011) Mark R. Gilbert et al.   JOURNAL OF NEURO-ONCOLOGY

TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

(2011) Ha-Long Nguyen et al.   LABORATORY INVESTIGATION

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

(2010) J. Wei et al.   CLINICAL CANCER RESEARCH

A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis

(2010) J H Tchaicha et al.   ONCOGENE

MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8

(2010) L Fang et al.   ONCOGENE

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Expression of Integrin α6β1 Enhances Tumorigenesis in Glioma Cells

(2009) Estelle Delamarre et al.   AMERICAN JOURNAL OF PATHOLOGY

Reduced Expression of Integrin αvβ8 Is Associated with Brain Arteriovenous Malformation Pathogenesis

(2009) Hua Su et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-β

(2009) Andres Rojas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

Cell adhesion and signaling networks in brain neurovascular units

(2009) Joseph H McCarty   CURRENT OPINION IN HEMATOLOGY

 8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain

(2009) A. K. Mobley et al.   JOURNAL OF CELL SCIENCE

The nuances of therapy

(2009) Lee M. Ellis et al.   NATURE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

The Mammary Progenitor Marker CD61/ 3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis

(2008) F. Vaillant et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit

(2008) Hiroyuki Nakajima et al.   JOURNAL OF CELL BIOLOGY

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE