Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats

(2012) Yong Pan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin Extract for Prevention of Type 2 Diabetes

(2012) S. Chuengsamarn et al.   DIABETES CARE

Curcumin induces apoptosis in tumor necrosis factor-alpha-treated HaCaT cells

(2012) Jun Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis

(2012) Binu Chandran et al.   PHYTOTHERAPY RESEARCH

Counteracting effect of TRPC1-associated Ca2+ influx on TNF-α-induced COX-2-dependent prostaglandin E2 production in human colonic myofibroblasts

(2011) Lin Hai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Innovative Preparation of Curcumin for Improved Oral Bioavailability

(2011) Hiroki Sasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Curcumin Ameliorates Cardiac Inflammation in Rats with Autoimmune Myocarditis

(2011) Sayaka Mito et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes

(2011) Vânia O. Gutierres et al.   BRITISH JOURNAL OF NUTRITION

Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin

(2011) Zhen-Yu He et al.   CANCER INVESTIGATION

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

(2011) R. E. Carroll et al.   Cancer Prevention Research

Curcumin Treatment Suppresses IKKβ Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study

(2011) Suejung G. Kim et al.   CLINICAL CANCER RESEARCH

Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: Effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines

(2011) Mona F. El-Azab et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synergistic activity of curcumin with methotrexate in ameliorating Freund's Complete Adjuvant induced arthritis with reduced hepatotoxicity in experimental animals

(2011) David Banji et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Safety assessment of a solid lipid curcumin particle preparation: Acute and subchronic toxicity studies

(2011) Paresh Dadhaniya et al.   FOOD AND CHEMICAL TOXICOLOGY

The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

(2011) Mohamed A. El-Moselhy et al.   FOOD AND CHEMICAL TOXICOLOGY

Epigenetic changes induced by curcumin and other natural compounds

(2011) Simone Reuter et al.   Genes and Nutrition

Curcumin for clinical and endoscopic remission in ulcerative colitis

(2011) Conor Lahiff et al.   INFLAMMATORY BOWEL DISEASES

Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model

(2011) El-Sayed M. Ammar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression

(2011) Chuan-tao Tu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-α-induced oxidative stress, colitis and hepatotoxicity in mice

(2011) Souad Mouzaoui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytesin Vitro

(2011) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral Supplementation of Turmeric Decreases Proteinuria, Hematuria, and Systolic Blood Pressure in Patients Suffering From Relapsing or Refractory Lupus Nephritis: A Randomized and Placebo-controlled Study

(2011) Parviz Khajehdehi et al.   JOURNAL OF RENAL NUTRITION

Curcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

(2011) Gulden Avci et al.   JOURNAL OF SURGICAL RESEARCH

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

Curcumin Attenuates Aluminum-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Brain

(2011) Pooja Khanna Sood et al.   NEUROTOXICITY RESEARCH

Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study

(2011) Parviz Khajehdehi et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

RETRACTED: Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake

(2010) Vivek R. Yadav et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis of mono-carbonyl analogues of curcumin and their effects on inhibition of cytokine release in LPS-stimulated RAW 264.7 macrophages

(2010) Chengguang Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer

(2010) Mathilde Bayet-Robert et al.   CANCER BIOLOGY & THERAPY

A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

(2010) Masashi Kanai et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal

(2010) Jaydip Biswas et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Curcumin attenuates inflammatory response in IL-1β-induced human synovial fibroblasts and collagen-induced arthritis in mouse model

(2010) Dong-Oh Moon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients

(2010) Chuchart Koosirirat et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers

(2010) Vikram S. Gota et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition

(2010) Se-Woong Oh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice

(2010) S. Bansal et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice

(2010) Isabel Villegas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin and Gemcitabine in Patients With Advanced Pancreatic Cancer

(2010) Ron Epelbaum et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects

(2010) Jennie Wickenberg et al.   Nutrition Journal

Tetrahydrocurcuminoid Cream Plus Targeted Narrowband UVB Phototherapy for Vitiligo: A Preliminary Randomized Controlled Study

(2010) Pravit Asawanonda et al.   PHOTOMEDICINE AND LASER SURGERY

Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice

(2010) Mao-Wei Yang et al.   PHYTOMEDICINE

Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

(2010) Wei-Bing Song et al.   PLoS One

Anti-Inflammatory Effects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation

(2010) Stefan Bereswill et al.   PLoS One

Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen

(2010) Hisamitsu Ide et al.   PROSTATE

Dietary Curcumin Increases Antioxidant Defenses in Lung, Ameliorates Radiation-Induced Pulmonary Fibrosis, and Improves Survival in Mice

(2010) James C. Lee et al.   RADIATION RESEARCH

Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress

(2010) Balwant Rai et al.   Journal of Oral Science

Effect of Curcumin on Nuclear Factor κB Signaling Pathways in Human Chronic Myelogenous K562 Leukemia Cells

(2009) Simone Reuter et al.   Annals of the New York Academy of Sciences

Curcumin, a Potential Inhibitor of Up-regulation of TNF-alpha and IL-6 Induced by Palmitate in 3T3-L1 Adipocytes through NF-kappaB and JNK Pathway

(2009) Shao-Ling WANG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock

(2009) Sang Sik Yun et al.   BIOTECHNOLOGY LETTERS

Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1β and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease

(2009) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids

(2009) Ruchaneekorn W. Kalpravidh et al.   CLINICAL BIOCHEMISTRY

The Potential Role of Curcumin in Patients with Monoclonal Gammopathy of Undefined Significance--Its Effect on Paraproteinemia and the Urinary N-Telopeptide of Type I Collagen Bone Turnover Marker

(2009) T. Golombick et al.   CLINICAL CANCER RESEARCH

Curcumin has Bright Prospects for the Treatment of Inflammatory Bowel Disease

(2009) Hiroyuki Hanai et al.   CURRENT PHARMACEUTICAL DESIGN

Oral Administration of Curcumin Emulsified in Carboxymethyl Cellulose Has a Potent Anti-inflammatory Effect in the IL-10 Gene-Deficient Mouse Model of IBD

(2009) Victoria Y. L. Ung et al.   DIGESTIVE DISEASES AND SCIENCES

Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells

(2009) Yingzi Cong et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis

(2009) Chau Ling Tham et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model

(2009) Hossam M.M. Arafa et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-α

(2009) M. Carmen Ramirez-Tortosa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni

(2009) Gamal Allam   IMMUNOBIOLOGY

Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

(2009) Osman Ciftci et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes

(2009) M. Mathy-Hartert et al.   INFLAMMATION RESEARCH

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide

(2009) Lijia Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Serenoa repens associated with Urtica dioica (ProstaMEV®) and curcumin and quercitin (FlogMEV®) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomised study

(2009) Tommaso Cai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin

(2009) Guang Liang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model

(2009) S. Nandal et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression

(2009) Y.-M. Yu et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Effect of Oral Curcumin on Déjérine-Sottas Disease

(2009) Joshua Burns et al.   PEDIATRIC NEUROLOGY

TNF-α inhibitors in asthma and COPD: We must not throw the baby out with the bath water

(2009) Maria Gabriella Matera et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection

(2008) C. B. Larmonier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2

(2008) Koremu K. Meja et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-α, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic Rats

(2008) Sushil K. Jain et al.   ANTIOXIDANTS & REDOX SIGNALING

Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide

(2008) Dong-Oh Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

(2008) Guang Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient ( mdr1a−/−) mice, a model of inflammatory bowel diseases

(2008) Katia Nones et al.   BRITISH JOURNAL OF NUTRITION

Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects

(2008) S. K. Vareed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-κB/p300 binding in human synovial fibroblasts

(2008) Kwok-Man Tong et al.   CELLULAR SIGNALLING

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Effect of Dietary Turmeric on Breath Hydrogen

(2008) Akito Shimouchi et al.   DIGESTIVE DISEASES AND SCIENCES

Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus and reduces fever during LPS-induced systemic inflammation in rabbits

(2008) Wu-Tein Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model

(2008) Amit Gupta et al.   IMMUNOBIOLOGY

Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent

(2008) Claire Billerey-Larmonier et al.   INFLAMMATORY BOWEL DISEASES

Therapeutic strategies for the management of ulcerative colitis

(2008) Siew C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial

(2008) Shanu Kohli Kurd et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis

(2008) A. Lubbad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide

(2008) Li Jia Zhang et al.   NEUROSCIENCE LETTERS

Synergistic Effect of Combination of Phenethyl Isothiocyanate and Sulforaphane or Curcumin and Sulforaphane in the Inhibition of Inflammation

(2008) Ka Lung Cheung et al.   PHARMACEUTICAL RESEARCH

Anti-Inflammatory Activity of Curcumin in Macrophages Stimulated by Lipopolysaccharides from Porphyromonas gingivalis

(2008) Dong Chen et al.   PHARMACOLOGY

Curcumin reverses attenuated carbachol-induced contraction of the colon in a rat model of colitis

(2008) Asmaa S. Lubbad et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Treatment of inflammatory bowel disease: A review of medical therapy

(2008) Patricia L Kozuch et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach

(2008) Meghna R Adhvaryu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effect of NCB-02, Atorvastatin and Placebo on Endothelial Function, Oxidative Stress and Inflammatory Markers in Patients with Type 2 Diabetes Mellitus

(2008) P Usharani et al.   Drugs in research & development

Turmeric-based diet can delay apoptosis without modulating NF-κB in unilateral ureteral obstruction in rats

(2007) Reem M. Hashem et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY