The Toxicity and Polymorphism of β-Amyloid Oligomers

Parkin overexpression attenuates Aβ-induced mitochondrial dysfunction in HEK293 cells by restoring impaired mitophagy

(2020) Hongmei Wang et al.   LIFE SCIENCES

Involvement of p75NTR in the effects of Aβ on L-type Ca2+ channel in cultured neuronal networks

(2020) Yifan Wang et al.   LIFE SCIENCES

Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer’s disease via activation of α7nAChR

(2020) Ke-Wei Chang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Treadmill Exercise Attenuates Aβ-Induced Mitochondrial Dysfunction and Enhances Mitophagy Activity in APP/PS1 Transgenic Mice

(2020) Na Zhao et al.   NEUROCHEMICAL RESEARCH

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

(2020) Fang Zhang et al.   Science Translational Medicine

Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer’s disease

(2020) Min Seok Baek et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

(2020) Thomas C. T. Michaels et al.   Nature Chemistry

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

(2019) Rik Ossenkoppele et al.   NEUROLOGY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer’s brain

(2019) Gunnar Brinkmalm et al.   BRAIN

A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

(2019) Michael J Pontecorvo et al.   BRAIN

Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor

(2019) Erika Cecon et al.   BRITISH JOURNAL OF PHARMACOLOGY

High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage

(2019) Taro Yasumoto et al.   FASEB JOURNAL

Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy

(2019) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease

(2019) David Henley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

(2019) Lisa Vermunt et al.   Alzheimers & Dementia

Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease

(2019) James A R Nicoll et al.   BRAIN

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity

(2019) Evgeny P. Barykin et al.   Cells

Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid-induced Ca2+ hyperexcitation

(2019) Julianna L. Sun et al.   NEUROBIOLOGY OF AGING

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

(2019) Grant T. Corbett et al.   ACTA NEUROPATHOLOGICA

Kinetic study of Aβ(1-42) amyloidosis in the presence of ganglioside-containing vesicles

(2019) Yanping Dai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Neurotrophin receptor p75 mediates amyloid β-induced tau pathology

(2019) Lin-Lin Shen et al.   NEUROBIOLOGY OF DISEASE

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Direct Evidence of the Presence of Cross-Linked Aβ Dimers in the Brains of Alzheimer’s Disease Patients

(2018) Aurelio Vázquez de la Torre et al.   ANALYTICAL CHEMISTRY

Secondary nucleation in amyloid formation

(2018) Mattias Törnquist et al.   CHEMICAL COMMUNICATIONS

Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease

(2018) Barbara Mroczko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cysteine-Rich Repeat Domains 2 and 4 are Amyloid-β Binding Domains of Neurotrophin Receptor p75NTR and Potential Targets to Block Amyloid-β Neurotoxicity

(2018) Ye-Ran Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β Induces AMPA Receptor Ubiquitination and Degradation in Primary Neurons and Human Brains of Alzheimer’s Disease

(2018) Yanmin Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in aDrosophilamodel of Alzheimer disease

(2018) Nadine D. Younan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Physicochemical Interaction of Aβ40 with a GM1 Ganglioside-Containing Lipid Membrane

(2018) Majid Vahed et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity

(2018) Katiuscia Pagano et al.   MOLECULAR NEUROBIOLOGY

Aβ dimers induce behavioral and neurochemical deficits of relevance to early Alzheimer's disease

(2018) Laila Abdel-Hafiz et al.   NEUROBIOLOGY OF AGING

Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease

(2018) Kazuyuki Takata et al.   NEUROBIOLOGY OF AGING

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer

(2018) Minkyung Lee et al.   NEUROPHARMACOLOGY

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Inhibiting amyloid-ß cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

(2018) Qin Cao et al.   Nature Chemistry

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways

(2018) Ke-Wei Chang et al.   NEUROCHEMISTRY INTERNATIONAL

Effect of Cholesterol on Membrane Fluidity and Association of Aβ Oligomers and Subsequent Neuronal Damage: A Double-Edged Sword

(2018) Eduardo J. Fernández-Pérez et al.   Frontiers in Aging Neuroscience

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

(2018) Zhong Xie et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice

(2018) Lei Qian et al.   MOLECULAR NEUROBIOLOGY

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice

(2018) Michaela Kerstin Müller et al.   Acta Neuropathologica Communications

Cholesterol Changes the Mechanisms of Aβ Peptide Binding to the DMPC Bilayer

(2017) Christopher Lockhart et al.   Journal of Chemical Information and Modeling

Amyloid β-Derived Diffusible Ligands (ADDLs) Induce Abnormal Autophagy Associated with Aβ Aggregation Degree

(2017) Jie Wen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis

(2017) Khalil Saadipour et al.   JOURNAL OF NEUROCHEMISTRY

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ

(2017) Adam G. Kreutzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Targeting glutamatergic and cellular prion protein mechanisms of amyloid β-mediated persistent synaptic plasticity disruption: Longitudinal studies

(2017) Dainan Zhang et al.   NEUROPHARMACOLOGY

Binding of protofibrillar Aβ trimers to lipid bilayer surface enhances Aβ structural stability and causes membrane thinning

(2017) Xuewei Dong et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of β-amyloid oligomer

(2017) Seung-Jun Yoo et al.   Cell Death & Disease

Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model

(2017) Rui Hu et al.   Cell Death & Disease

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation

(2017) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer’s disease

(2017) Jingyi Liang et al.   PLoS One

Reciprocal Molecular Interactions between the Aβ Peptide Linked to Alzheimer’s Disease and Insulin Linked to Diabetes Mellitus Type II

(2016) Jinghui Luo et al.   ACS Chemical Neuroscience

The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer

(2016) Tiernan T. O’Malley et al.   BIOCHEMISTRY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Ion Channel Formation by Amyloid-β42Oligomers but Not Amyloid-β40in Cellular Membranes

(2016) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-bound tetramer and trimer Aβ oligomeric species correlate with toxicity towards cultured neurons

(2016) Metta K. Jana et al.   JOURNAL OF NEUROCHEMISTRY

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Soluble Conformers of A  and Tau Alter Selective Proteins Governing Axonal Transport

(2016) M. A. Sherman et al.   JOURNAL OF NEUROSCIENCE

Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease

(2016) Xiao-Dong Shi et al.   JOURNAL OF NEUROSCIENCE

Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin

(2016) Teng Wang et al.   NEUROPHARMACOLOGY

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Lipid microdomain modification sustains neuronal viability in models of Alzheimer’s disease

(2016) Silke Herzer et al.   Acta Neuropathologica Communications

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

(2015) Jessica M. Mc Donald et al.   Alzheimers & Dementia

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

(2015) Laura T. Haas et al.   BRAIN

Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes

(2015) Ellen Hubin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity

(2015) Takashi Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insight into an Alzheimer’s Brain-Derived Spherical Assembly of Amyloid β by Solid-State NMR

(2015) Sudhakar Parthasarathy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

(2015) Olga Szczepankiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons

(2015) Kathlyn J. Gan et al.   MOLECULAR BIOLOGY OF THE CELL

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease

(2015) X-Q Yao et al.   MOLECULAR PSYCHIATRY

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

(2015) Takayuki Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

Pan-Amyloid Oligomer Specific scFv Antibody Attenuates Memory Deficits and Brain Amyloid Burden in Mice with Alzheimer’s Disease

(2014) Min Zhao et al.   Current Alzheimer Research

Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits

(2014) Eric C. Miller et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amyloid Beta-Derived Diffusible Ligands (ADDLs) Induce Abnormal Expression of Insulin Receptors in Rat Hippocampal Neurons

(2014) Xin Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

β2Adrenergic Receptor, Protein Kinase A (PKA) and c-Jun N-terminal Kinase (JNK) Signaling Pathways Mediate Tau Pathology in Alzheimer Disease Models

(2013) Dayong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

(2012) Hyunbum Jang et al.   Journal of Chemical Theory and Computation

Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity

(2012) Marcus Fändrich   JOURNAL OF MOLECULAR BIOLOGY

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conformation-dependent scFv antibodies specifically recognize the oligomers assembled from various amyloids and show colocalization of amyloid fibrils with oligomers in patients with amyloidoses

(2011) Xi Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses

(2011) Satoko Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Binding of amyloid β peptide to β2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

(2010) Dayong Wang et al.   FASEB JOURNAL

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

(2010) Miranda N. Reed et al.   NEUROBIOLOGY OF AGING

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53-Dependent Transcriptional Control of Cellular Prion by Presenilins

(2009) B. Vincent et al.   JOURNAL OF NEUROSCIENCE

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Alpha7 neuronal nicotinic receptors: The missing link to understanding Alzheimer’s etiopathology?

(2009) Merouane Bencherif et al.   MEDICAL HYPOTHESES

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life

(2009) Ganesh M. Shankar et al.   NEUROBIOLOGY OF DISEASE

Memory and the NMDA Receptors

(2009) Fei Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Aβ-globulomers are formed independently of the fibril pathway

(2008) Gerald P. Gellermann et al.   NEUROBIOLOGY OF DISEASE