DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity

mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

(2018) Michael W. Webster et al.   MOLECULAR CELL

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

(2018) Hyerim Yi et al.   MOLECULAR CELL

Eukaryotic translation initiation factor 4AII contributes to microRNA-122 regulation of hepatitis C virus replication

(2018) Choudhary Shoaib Ahmed et al.   NUCLEIC ACIDS RESEARCH

A widespread alternate form of cap-dependent mRNA translation initiation

(2018) Columba de la Parra et al.   Nature Communications

Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

(2018) Jacob W Freimer et al.   eLife

The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4–Not nuclease module

(2018) Lorenzo Pavanello et al.   BIOCHEMICAL JOURNAL

DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs

(2017) Masashi Yamaji et al.   NATURE

Beyond the known functions of the CCR4-NOT complex in gene expression regulatory mechanisms

(2016) Marta Ukleja et al.   BIOESSAYS

miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

(2016) Duygu Kuzuoğlu‐Öztürk et al.   EMBO JOURNAL

Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle

(2016) Jong-Eun Park et al.   MOLECULAR CELL

Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation inC. elegans

(2016) Mathieu N. Flamand et al.   NUCLEIC ACIDS RESEARCH

The DDX6–4E-T interaction mediates translational repression and P-body assembly

(2016) Anastasiia Kamenska et al.   NUCLEIC ACIDS RESEARCH

Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID)

(2016) Christoph Schweingruber et al.   PLoS One

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1

(2016) James A.W. Stowell et al.   Cell Reports

The Ccr4-Not complex is a key regulator of eukaryotic gene expression

(2016) Martine A. Collart   Wiley Interdisciplinary Reviews-RNA

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4–Not nuclease module

(2015) Maryati Maryati et al.   BIOCHEMICAL JOURNAL

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

(2015) F. Raza et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

(2015) A Craxton et al.   CELL DEATH AND DIFFERENTIATION

eIF4AII is dispensable for miRNA-mediated gene silencing

(2015) Gabriela Galicia-Vázquez et al.   RNA

TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1

(2015) Lian-Hong Zou et al.   Oncotarget

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex

(2015) Sevim Ozgur et al.   Cell Reports

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs

(2015) Tamiko Nishimura et al.   Cell Reports

Poly(A)-binding proteins are required for diverse biological processes in metazoans

(2014) Richard W.P. Smith et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MicroRNAs Block Assembly of eIF4F Translation Initiation Complex in Drosophila

(2014) Takashi Fukaya et al.   MOLECULAR CELL

MicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans

(2014) Akira Fukao et al.   MOLECULAR CELL

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

(2014) Christopher Rouya et al.   RNA

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

(2013) Jean-Philippe Lambert et al.   NATURE METHODS

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

(2013) H. A. Meijer et al.   SCIENCE

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

(2012) Alain-Pierre Petit et al.   NUCLEIC ACIDS RESEARCH

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Human Ccr4–Not complexes contain variable deadenylase subunits

(2009) Nga-Chi Lau et al.   BIOCHEMICAL JOURNAL

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

(2009) Marc R. Fabian et al.   MOLECULAR CELL

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

(2008) Yi Wen Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deadenylation is a widespread effect of miRNA regulation

(2008) A. Eulalio et al.   RNA

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

(2008) M. Landthaler et al.   RNA