Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36

The G-quadruplex (G4) resolvase DHX36 efficiently and specifically disrupts DNA G4s via a translocation-based helicase mechanism

(2017) Philip M. Yangyuoru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human DDX21 binds and unwinds RNA guanine quadruplexes

(2017) Ewan K.S. McRae et al.   NUCLEIC ACIDS RESEARCH

Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA

(2017) Yangzi He et al.   RNA

Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

(2017) Marcel J Tauchert et al.   eLife

Structural Basis of DEAH/RHA Helicase Activity

(2017) Michael C. Chen et al.   Crystals

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

Single-molecule imaging reveals a common mechanism shared by G-quadruplex–resolving helicases

(2016) Ramreddy Tippana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryoteChaetomium thermophilum

(2016) Marcel J. Tauchert et al.   Acta Crystallographica Section F-Structural Biology Communications

Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling

(2015) J. Rajan Prabu et al.   MOLECULAR CELL

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase

(2015) Michael C. Chen et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex

(2015) Brahim Heddi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development

(2015) Junwei Nie et al.   Cell Reports

Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3’-Tail Sequences Are Sufficient for Tight and Complete Binding

(2015) Philip J. Smaldino et al.   PLoS One

Small-molecule quadruplex-targeted drug discovery

(2014) Stephan A. Ohnmacht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

G-quadruplex conformation and dynamics are determined by loop length and sequence

(2014) Ramreddy Tippana et al.   NUCLEIC ACIDS RESEARCH

OptimizedE. coliexpression strain LOBSTR eliminates common contaminants from His-tag purification

(2013) Kasper R. Andersen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis

(2012) J. C. Lai et al.   BLOOD

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

(2012) E. P. Booy et al.   NUCLEIC ACIDS RESEARCH

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme

(2011) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Prp43p contains a processive helicase structural architecture with a specific regulatory domain

(2010) Hélène Walbott et al.   EMBO JOURNAL

Structural basis for the function of DEAH helicases

(2010) Yangzi He et al.   EMBO REPORTS

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU

(2010) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

Recruitment of the RNA Helicase RHAU to Stress Granules via a Unique RNA-binding Domain

(2008) Kateřina Chalupníková et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY