Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

(2020) Ashwini Hinge et al.   Cell Stem Cell

Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance

(2020) Abhishek K. Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML

(2020) Yoko Tabe et al.   Frontiers in Oncology

Advances in drug therapy for mitochondrial diseases

(2020) Lufei Zhang et al.   Annals of Translational Medicine

ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

(2019) Hei-Man Chow et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome

(2019) Amanda McBride et al.   Frontiers in Oncology

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells

(2019) Petra Jagust et al.   Frontiers in Pharmacology

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

(2019) Courtney L. Jones et al.   BLOOD

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy

(2019) Mark A. Gregory et al.   CLINICAL CANCER RESEARCH

Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

(2019) Lina Han et al.   HAEMATOLOGICA

Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia

(2019) Nicolas Chapuis et al.   Frontiers in Oncology

BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia

(2019) Jing-dong Zhou et al.   Diagnostic Pathology

Selective Autophagy in Normal and Malignant Hematopoiesis

(2019) Sebastian E. Koschade et al.   JOURNAL OF MOLECULAR BIOLOGY

Metabolic Plasticity of Acute Myeloid Leukemia

(2019) Kreitz et al.   Cells

Inhibition of Fatty Acid Metabolism Re-Sensitizes Resistant Leukemia Stem Cells to Venetoclax with Azacitidine

(2019) Courtney L Jones et al.   BLOOD

Modulation of Reactive Oxygen Species in Health and Disease

(2019) Solomon Habtemariam   Antioxidants

Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia

(2019) Gail J. Roboz et al.   BLOOD

Differential redox-regulation and mitochondrial dynamics in normal and leukemic hematopoietic stem cells: A potential window for leukemia therapy

(2019) Katharina Mattes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expression of Intracellular Reactive Oxygen Species in Hematopoietic Stem Cells Correlates with Time to Neutrophil and Platelet Engraftment in Patients Undergoing Autologous Bone Marrow Transplantation

(2018) Lijun Bai et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

(2018) Matthew S. Waitkus et al.   CANCER CELL

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

(2018) Shanshan Pei et al.   Cell Stem Cell

Targeting the IDH2 Pathway in Acute Myeloid Leukemia

(2018) Maria L. Amaya et al.   CLINICAL CANCER RESEARCH

Mitochondria and the dynamic control of stem cell homeostasis

(2018) Pawel Lisowski et al.   EMBO REPORTS

Assembly of mammalian oxidative phosphorylation complexes I–V and supercomplexes

(2018) Alba Signes et al.   Essays in Biochemistry

Hematopoietic stem cell fate through metabolic control

(2018) Kyoko Ito et al.   EXPERIMENTAL HEMATOLOGY

Efficacy of the combination of venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia

(2018) Ibrahim Aldoss et al.   HAEMATOLOGICA

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

(2018) Rodrigo Prieto-Bermejo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

(2018) Lynn Quek et al.   NATURE MEDICINE

Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

(2018) Bin Guo et al.   NATURE MEDICINE

Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease

(2018) L Holper et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy of the combination of venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia

(2018) Ibrahim Aldoss et al.   HAEMATOLOGICA

The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

(2018) Eléonore Toufektchan et al.   Cancers

A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute Myelogenous Leukemia

(2018) Haley E. Ramsey et al.   Cancer Discovery

Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia

(2018) Sharon Wu et al.   Scientific Reports

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Mitochondrial Dynamics in Stem Cells and Differentiation

(2018) Bong Seo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions

(2017) Daiki Karigane et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

MicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid Leukemia

(2017) Emilia L. Lim et al.   JOURNAL OF CLINICAL ONCOLOGY

Pathways and mechanisms of venetoclax resistance

(2017) Prithviraj Bose et al.   LEUKEMIA & LYMPHOMA

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin

(2017) Tadato Ban et al.   NATURE CELL BIOLOGY

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

(2017) Jarmon G. Lees et al.   Stem Cells International

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

(2016) M. A. Anderson et al.   BLOOD

Cellular Metabolism and Induced Pluripotency

(2016) Jun Wu et al.   CELL

Mitochondrial cytopathies

(2016) Ayman W. El-Hattab et al.   CELL CALCIUM

HSC Fate Is Tethered to Mitochondria

(2016) Lauren P. Diebold et al.   Cell Stem Cell

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells

(2016) X. Niu et al.   CLINICAL CANCER RESEARCH

Isocitrate dehydrogenase mutations in myeloid malignancies

(2016) B C Medeiros et al.   LEUKEMIA

The Emerging Network of Mitochondria-Organelle Contacts

(2016) Andrew Murley et al.   MOLECULAR CELL

Influence of tissue, diet, and enzymatic remodeling on cardiolipin fatty acyl profile

(2016) Ryan M. Bradley et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency

(2016) Ariana P. Gatt et al.   MOVEMENT DISORDERS

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

(2016) Larry L. Luchsinger et al.   NATURE

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?

(2016) Serena Stanga et al.   Aging-US

Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient Mice

(2016) Ezgi Eyluel Bankoglu et al.   PLoS One

Apoptosis-Related Gene Expression Profiling in Hematopoietic Cell Fractions of MDS Patients

(2016) Saskia MC Langemeijer et al.   PLoS One

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

(2015) E. A. Lee et al.   CANCER RESEARCH

The ATM–BID pathway plays a critical role in the DNA damage response by regulating mitochondria metabolism

(2015) A Gross et al.   CELL DEATH AND DIFFERENTIATION

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

(2015) K Palikaras et al.   CELL DEATH AND DIFFERENTIATION

Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells

(2015) Ling Li et al.   CURRENT OPINION IN HEMATOLOGY

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

(2015) Z. Zhang et al.   EMBO JOURNAL

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

Nuclear gene mutations as the cause of mitochondrial complex III deficiency

(2015) Erika Fernández-Vizarra et al.   Frontiers in Genetics

The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation

(2014) Remco J. Molenaar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value

(2014) W.-L. Chen et al.   BLOOD

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels

(2014) Kelly D Sullivan et al.   CELL CYCLE

Stem cells and the impact of ROS signaling

(2014) C. L. Bigarella et al.   DEVELOPMENT

After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization

(2014) Jingzhen Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Mitophagy in hematopoietic stem cells

(2013) Aashish Joshi et al.   Autophagy

Sulfide inhibition of and metabolism by cytochromecoxidase

(2013) Peter Nicholls et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

BCL-2 Inhibition: Stemming the Tide of Myeloid Malignancies

(2013) Leah J. Hogdal et al.   Cell Stem Cell

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Asymmetric cell division of stem and progenitor cells during homeostasis and cancer

(2013) Sandra Gómez-López et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stem cell metabolism in tissue development and aging

(2013) N. Shyh-Chang et al.   DEVELOPMENT

Mitochondrial cytochromecoxidase subunit II variations predict adverse prognosis in cytogenetically normal acute myeloid leukaemia

(2013) Trine Silkjaer et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Characterization and prognostic significance of mitochondrial DNA variations in acute myeloid leukemia

(2013) Trine Silkjaer et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia

(2013) Steven M. Chan et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome

(2013) Jan Dudek et al.   Stem Cell Research

Cited2 Is Required for the Maintenance of Glycolytic Metabolism in Adult Hematopoietic Stem Cells

(2013) Jinwei Du et al.   STEM CELLS AND DEVELOPMENT

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Emerging Metabolic Targets in the Therapy of Hematological Malignancies

(2013) Zaira Leni et al.   Biomed Research International

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)

(2013) V. C. De Giusti et al.   Frontiers in Physiology

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Succinate Dehydrogenase-deficient Tumors

(2012) Justine A. Barletta et al.   ADVANCES IN ANATOMIC PATHOLOGY

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Structural analysis of cytochrome bc1 complexes: Implications to the mechanism of function

(2012) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial complex II, a novel target for anti-cancer agents

(2012) Katarina Kluckova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

(2012) Z. Unnisa et al.   BLOOD

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

A role for GPx3 in activity of normal and leukemia stem cells

(2012) Olivier Herault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical and biochemical features associated with BCS1L mutation

(2012) Mohammed Al-Owain et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Selective induction of TP53I3/p53-inducible gene 3 (PIG3) in myeloid leukemic cells, but not in normal cells, by Nutlin-3

(2012) Rebecca Voltan et al.   MOLECULAR CARCINOGENESIS

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mechanisms of mitochondrial diseases

(2011) Emil Ylikallio et al.   ANNALS OF MEDICINE

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

(2011) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia

(2011) F Damm et al.   LEUKEMIA

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

The p53 tumor suppressor protein regulates hematopoietic stem cell fate

(2010) Takashi Asai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chloramphenicol Causes Mitochondrial Stress, Decreases ATP Biosynthesis, Induces Matrix Metalloproteinase-13 Expression, and Solid-Tumor Cell Invasion

(2010) Ching-Hao Li et al.   TOXICOLOGICAL SCIENCES

Hematopoietic stem cell: self-renewal versus differentiation

(2010) Jun Seita et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

(2009) Francien H van Nederveen et al.   LANCET ONCOLOGY

Amino Acids and Mitochondrial Biogenesis

(2008) Enzo Nisoli et al.   AMERICAN JOURNAL OF CARDIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Chloramphenicol Induces Abnormal Differentiation and Inhibits Apoptosis in Activated T Cells

(2008) Z.-R. Yuan et al.   CANCER RESEARCH

Transcriptional targets of sirtuins in the coordination of mammalian physiology

(2008) Jerome N Feige et al.   CURRENT OPINION IN CELL BIOLOGY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Foxo3a Inhibits Cardiomyocyte Hypertrophy through Transactivating Catalase

(2008) Wei-Qi Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL

Leigh and Leigh-Like Syndrome in Children and Adults

(2008) Josef Finsterer   PEDIATRIC NEUROLOGY

Leber hereditary optic neuropathy mutations in the ND6 subunit of mitochondrial complex I affect ubiquinone reduction kinetics in a bacterial model of the enzyme

(2007) Jukka Pätsi et al.   BIOCHEMICAL JOURNAL

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY