Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 106, Issue 1, Pages 18-26Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12185-017-2261-x
Keywords
Hematopoietic stem cell; Hematopoietic progenitor cell; Metabolomics; Niche; Leukemic stem cell
Categories
Funding
- MEXT/JSPS [26115005, 15H04861, 16K15507, 26115001, 15K21751]
- National Center for Global Health and Medicine [26-001]
- AMED-CREST
- AMED Grant for Realization of Regenerative Medicine
- Tokyo Biochemical Research Foundation
- Uehara Memorial Foundation
- Japan Leukemia Research Fund
- Japan Rheumatism Foundation
- Japan Foundation for Applied Enzymology
- Kanae Foundation for the Promotion of Medical Science
- KAKENHI Grant from MEXT/JSPS [17K16199]
- Grants-in-Aid for Scientific Research [15K21751, 16K15507, 15H04861, 26115001, 26115005] Funding Source: KAKEN
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Hematopoietic stem cells (HSCs) exhibit multilineage differentiation and self-renewal activities that maintain the entire hematopoietic system during an organism's lifetime. These abilities are sustained by intrinsic transcriptional programs and extrinsic cues from the microenvironment or niche. Recent studies using metabolomics technologies reveal that metabolic regulation plays an essential role in HSC maintenance. Metabolic pathways provide energy and building blocks for other factors functioning at steady state and in stress. Here we review recent advances in our understanding of metabolic regulation in HSCs relevant to cell cycle quiescence, symmetric/asymmetric division, and proliferation following stress and lineage commitment, and discuss the therapeutic potential of targeting metabolic factors or pathways to treat hematological malignancies.
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