The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Deciphering p53 signaling in tumor suppression

(2018) Stephano S Mello et al.   CURRENT OPINION IN CELL BIOLOGY

Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence

(2018) Guillaume Collin et al.   Cell Death & Disease

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

(2018) Yuhan Zhao et al.   eLife

Essential role for centromeric factors following p53 loss and oncogenic transformation

(2017) Dan Filipescu et al.   GENES & DEVELOPMENT

Dysfunction of the MDM2/p53 axis is linked to premature aging

(2017) Davor Lessel et al.   JOURNAL OF CLINICAL INVESTIGATION

Les liaisons dangereuses : p53, dyskératose congénitale et anémie de Fanconi

(2017) Eléonore Toufektchan et al.   M S-MEDECINE SCIENCES

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

(2017) Xiaolei Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SNM1B/Apollo in the DNA damage response and telomere maintenance

(2017) Maren Schmiester et al.   Oncotarget

p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita

(2017) Wilson Chun Fok et al.   Stem Cell Reports

Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”

(2016) Michael B. Kastan   CANCER RESEARCH

Fanconi anemia proteins in telomere maintenance

(2016) Jaya Sarkar et al.   DNA REPAIR

Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease

(2016) Baris Boyraz et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

(2016) Donglai Wang et al.   NATURE

The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein

(2016) Oleg Laptenko et al.   TRENDS IN BIOCHEMICAL SCIENCES

p53 downregulates the Fanconi anaemia DNA repair pathway

(2016) Sara Jaber et al.   Nature Communications

Timing of transcription during the cell cycle: Protein complexes binding to E2F, E2F/CLE, CDE/CHR, or CHR promoter elements define early and late cell cycle gene expression

(2016) Gerd A. Müller et al.   Oncotarget

p53 in the DNA-Damage-Repair Process

(2016) Ashley B. Williams et al.   Cold Spring Harbor Perspectives in Medicine

Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells

(2015) A Stedman et al.   CELL DEATH AND DIFFERENTIATION

Cell cycle regulation of human DNA repair and chromatin remodeling genes

(2015) Robin Mjelle et al.   DNA REPAIR

Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita

(2015) Hemanth Tummala et al.   JOURNAL OF CLINICAL INVESTIGATION

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

(2015) Diane H Moon et al.   NATURE GENETICS

PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells

(2015) Xiaokan Zhang et al.   NUCLEIC ACIDS RESEARCH

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

(2015) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

The molecular genetics of the telomere biology disorders

(2015) Alison A. Bertuch   RNA Biology

BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo

(2015) Orit Uziel et al.   Oncotarget

The Fanconi Anemia DNA Repair Pathway: Structural and Functional Insights into a Complex Disorder

(2014) Helen Walden et al.   Annual Review of Biophysics

Stress and DNA repair biology of the Fanconi anemia pathway

(2014) S. Longerich et al.   BLOOD

p53 and ribosome biogenesis stress: The essentials

(2014) Lior Golomb et al.   FEBS LETTERS

Inappropriate p53 activation during development induces features of CHARGE syndrome

(2014) Jeanine L. Van Nostrand et al.   NATURE

Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis

(2013) Sladana Bursac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

(2013) P.-J. Hamard et al.   GENES & DEVELOPMENT

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

Positive and negative feedback loops in the p53 and mRNA 3′ processing pathways

(2013) Emral Devany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes

(2013) Iva Simeonova et al.   Cell Reports

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

(2013) Bari J. Ballew et al.   PLoS Genetics

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

(2012) Marianne Quaas et al.   CELL CYCLE

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

(2012) Raphael Ceccaldi et al.   Cell Stem Cell

Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase

(2011) E. M. Parry et al.   BLOOD

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

(2011) Y. V. Wang et al.   GENES & DEVELOPMENT

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

Puma is required for p53-induced depletion of adult stem cells

(2010) Dongping Liu et al.   NATURE CELL BIOLOGY

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

(2010) Sophie Badie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Molecular Classification and Prognostication of Adrenocortical Tumors by Transcriptome Profiling

(2009) T. J. Giordano et al.   CLINICAL CANCER RESEARCH

Three birds with one stone

(2009) Franck Toledo et al.   NATURE

Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity

(2009) L. A. Donehower   Cold Spring Harbor Perspectives in Biology

Mouse Models of p53 Functions

(2009) G. Lozano   Cold Spring Harbor Perspectives in Biology

Clinical Outcomes and Correlates of TP53 Mutations and Cancer

(2009) A. I. Robles et al.   Cold Spring Harbor Perspectives in Biology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Engineered telomere degradation models dyskeratosis congenita

(2008) D. Hockemeyer et al.   GENES & DEVELOPMENT

Mutation of ERBB2 Provides a Novel Alternative Mechanism for the Ubiquitous Activation of RAS-MAPK in Ovarian Serous Low Malignant Potential Tumors

(2008) M. S. Anglesio et al.   MOLECULAR CANCER RESEARCH

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

(2008) Kelly A McGowan et al.   NATURE GENETICS

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY