Intracellular signalling pathways: targets to reverse immunosenescence

Effects of aging on human leukocytes (part I): immunophenotyping of innate immune cells

(2015) Ulrik Stervbo et al.   AGE

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

(2015) T. Fulop et al.   BIOGERONTOLOGY

Membrane nanodomains in T-cell antigen receptor signalling

(2015) Konstantina Nika et al.   Essays in Biochemistry

Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8+T-cell proliferation by distinct pathways

(2015) Sian M. Henson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture

(2015) Sarra Baëhl et al.   EXPERIMENTAL GERONTOLOGY

Immunologic manifestations of autophagy

(2015) Vojo Deretic et al.   JOURNAL OF CLINICAL INVESTIGATION

Paradoxical changes in innate immunity in aging: recent progress and new directions

(2015) Ruth R. Montgomery et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunosenescence: Implications for response to infection and vaccination in older people

(2015) Alejandra Pera et al.   MATURITAS

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Innate immune memory: a paradigm shift in understanding host defense

(2015) Mihai G Netea et al.   NATURE IMMUNOLOGY

TCR-Signaling Events in Cellular Metabolism and Specialization

(2015) Danielle A. Chisolm et al.   Frontiers in Immunology

Immunomodulatory role of high-density lipoproteins: impact on immunosenescence

(2014) Anis Larbi et al.   AGE

Epigenetic changes: The missing link

(2014) Diego Kyburz et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

(2014) Aurélie Le Page et al.   Cell Communication and Signaling

Physiological and pathological consequences of cellular senescence

(2014) Dominick G. A. Burton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Shaping of NK cell subsets by aging

(2014) Rafael Solana et al.   CURRENT OPINION IN IMMUNOLOGY

Cellular signaling in the aging immune system

(2014) Tamas Fulop et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanisms shaping the naïve T cell repertoire in the elderly — Thymic involution or peripheral homeostatic proliferation?

(2014) Qian Qi et al.   EXPERIMENTAL GERONTOLOGY

Naive T cells: The crux of cellular immune aging?

(2014) Victor Appay et al.   EXPERIMENTAL GERONTOLOGY

T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+CD28+ T cells but not in CD8+CD28− T cells

(2014) Christoph R. Arnold et al.   EXPERIMENTAL GERONTOLOGY

Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart

(2014) Phyllis-Jean Linton et al.   IMMUNOLOGY LETTERS

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflamm-aging does not simply reflect increases in pro-inflammatory markers

(2014) Vincent Morrisette-Thomas et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Disorders of Innate Immunity in Human ageing and effects of Nutraceutical Administration

(2014) Thea Magrone et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Cholesterol: A modulator of the phagocyte NADPH oxidase activity - A cell-free study

(2014) Rawand Masoud et al.   Redox Biology

The role of membrane rafts in Lck transport, regulation and signalling in T-cells

(2013) Leandro N. Ventimiglia et al.   BIOCHEMICAL JOURNAL

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans

(2013) Guillaume Spielmann et al.   BRAIN BEHAVIOR AND IMMUNITY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

From “truly naïve” to “exhausted senescent” T cells: When markers predict functionality

(2013) Anis Larbi et al.   CYTOMETRY PART A

Immunosenenescence: Role of cytomegalovirus

(2013) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Mammalian Target of Rapamycin Complex 2 Signaling Promotes Age-Related Decline in CD4 T Cell Signaling and Function

(2013) E. Perkey et al.   JOURNAL OF IMMUNOLOGY

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

(2013) N. P. Coussens et al.   MOLECULAR AND CELLULAR BIOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Pattern recognition receptor function in neutrophils

(2013) Christina J. Thomas et al.   TRENDS IN IMMUNOLOGY

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

Human T Cell Aging and the Impact of Persistent Viral Infections

(2013) T. Fülöp et al.   Frontiers in Immunology

The role of the T cell in age-related inflammation

(2012) Richard Macaulay et al.   AGE

Bordetella parapertussis Survives the Innate Interaction with Human Neutrophils by Impairing Bactericidal Trafficking inside the Cell through a Lipid Raft-Dependent Mechanism Mediated by the Lipopolysaccharide O Antigen

(2012) Juan Gorgojo et al.   INFECTION AND IMMUNITY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

The immunological synapse: a cause or consequence of T-cell receptor triggering?

(2011) Balbino Alarcón et al.   IMMUNOLOGY

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

(2011) J. R. Schoenborn et al.   Science Signaling

Dysregulation of human Toll-like receptor function in aging

(2010) Albert C. Shaw et al.   AGEING RESEARCH REVIEWS

Drug Discovery and Protein Tyrosine Phosphatases

(2009) Mark Blaskovich   CURRENT MEDICINAL CHEMISTRY

Aging and Neutrophils: There Is Still Much To Do

(2008) Carl F. Fortin et al.   REJUVENATION RESEARCH

Cytomegalovirus and human immunosenescence

(2008) Graham Pawelec et al.   REVIEWS IN MEDICAL VIROLOGY