In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

(2011) D. N. Vatakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

(2011) Bradford K Berges et al.   Retrovirology

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ−/− (NSG) BLT mice

(2011) Cheryl A. Stoddart et al.   VIROLOGY

Stem cell-based anti-HIV gene therapy

(2011) Scott G. Kitchen et al.   VIROLOGY

Enumeration of human antigen-specific naive CD8+ T cells reveals conserved precursor frequencies

(2010) C. Alanio et al.   BLOOD

CD8+ Cell Depletion Accelerates HIV-1 Immunopathology in Humanized Mice

(2010) S. Gorantla et al.   JOURNAL OF IMMUNOLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

Systemic Administration of Antiretrovirals Prior to Exposure Prevents Rectal and Intravenous HIV-1 Transmission in Humanized BLT Mice

(2010) Paul W. Denton et al.   PLoS One

Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS

(2010) Jeffrey D. Ahlers et al.   TRENDS IN IMMUNOLOGY

Quantifying the Impact of Human Immunodeficiency Virus-1 Escape From Cytotoxic T-Lymphocytes

(2010) Ulrich D. Kadolsky et al.   PLoS Computational Biology

Revisiting Immune Exhaustion During HIV Infection

(2010) Alka Khaitan et al.   Current HIV/AIDS Reports

Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface

(2009) A. Zloza et al.   BLOOD

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

(2009) Nilu Goonetilleke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells

(2009) H. Streeck et al.   JOURNAL OF VIROLOGY

Architecture and secondary structure of an entire HIV-1 RNA genome

(2009) Joseph M. Watts et al.   NATURE

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

(2009) Ronald T Mitsuyasu et al.   NATURE MEDICINE

Engineering Antigen-Specific T Cells from Genetically Modified Human Hematopoietic Stem Cells in Immunodeficient Mice

(2009) Scott G. Kitchen et al.   PLoS One

Visualizing Antigen-Specific and Infected Cells in Situ Predicts Outcomes in Early Viral Infection

(2009) Q. Li et al.   SCIENCE

Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response

(2009) Ryan M. Troyer et al.   PLoS Pathogens

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity

(2008) A. Joseph et al.   JOURNAL OF VIROLOGY

Dynamics of Immune Escape during HIV/SIV Infection

(2008) Christian L. Althaus et al.   PLoS Computational Biology

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

(2008) Paul W Denton et al.   PLOS MEDICINE