期刊
IMMUNOTHERAPY
卷 12, 期 13, 页码 1021-1034出版社
FUTURE MEDICINE LTD
DOI: 10.2217/imt-2020-0009
关键词
adoptive cell therapy; allotransplantation; autoantibody; autoimmune diseases; chimeric antigen receptor; infection; regulatory T cells
类别
资金
- National Natural and Scientific Foundation of China [81572988]
- Science & Technology Department of Sichuan Province [2016FZ0108, 2018SZ0117]
Adoptive cell therapy with chimeric antigen receptor T (CAR-T) cells has achieved remarkable efficacy in the treatment of hematological malignancies, which has inspired researchers to expand the application of CAR-T-cell therapy to other medical conditions. Here, we review the current understanding and development of CAR-T-cell therapy for infectious diseases, autoimmune diseases and allotransplantation. The limitations and challenges of CAR-T-cell therapy in the treatment of these diseases and potential solutions to overcome these shortcomings are also discussed. With the development of novel designs of CARs and preclinical/clinical investigations, CAR-T-cell therapy is expected to be a potential cure option in a wide array of disease settings in the future.
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