MTOR‐initiated metabolic switch and degeneration in the retinal pigment epithelium

Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies

(2020) Shun-Yun Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice

(2019) Michael Landowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

(2019) Rinki Ratnapriya et al.   NATURE GENETICS

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

(2019) Ilan Y. Benador et al.   Cell Metabolism

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

(2019) Federica Storti et al.   eLife

SUBRETINAL DRUSENOID DEPOSIT IN AGE-RELATED MACULAR DEGENERATION

(2019) Ling Chen et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration

(2018) Younghwa Shin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

(2018) Bo Yu et al.   Science Signaling

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Subretinal Drusenoid Deposits AKA Pseudodrusen

(2018) Richard F. Spaide et al.   SURVEY OF OPHTHALMOLOGY

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

(2018) Bo Yu et al.   Science Signaling

Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration

(2018) Gulpreet Kaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells

(2018) Aditi Swarup et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury

(2017) Zhenyang Zhao et al.   FASEB JOURNAL

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis

(2016) Mei Chen et al.   AGING CELL

Rapamycin Inhibits Expression of Elongation of Very-long-chain Fatty Acids 1 and Synthesis of Docosahexaenoic Acid in Bovine Mammary Epithelial Cells

(2016) Zhixin Guo et al.   ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES

Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration

(2016) Nady Golestaneh et al.   Journal of Translational Medicine

Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium

(2016) Jianhai Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

(2016) Toshihide Kurihara et al.   eLife

Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE−/− mice with partial carotid ligation

(2015) Young-Mi Go et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Reference Standardization for Mass Spectrometry and High-resolution Metabolomics Applications to Exposome Research

(2015) Young-Mi Go et al.   TOXICOLOGICAL SCIENCES

Lipids, Lipid Genes, and Incident Age-Related Macular Degeneration: The Three Continent Age-Related Macular Degeneration Consortium

(2014) Ronald Klein et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Age- and Gene-Dosage–Dependent Cre-Induced Abnormalities in the Retinal Pigment Epithelium

(2014) Lizhi He et al.   AMERICAN JOURNAL OF PATHOLOGY

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Identifying Small Molecules via High Resolution Mass Spectrometry: Communicating Confidence

(2014) Emma L. Schymanski et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Cultured primary human fetal retinal pigment epithelium (hfRPE) as a model for evaluating RPE metabolism

(2014) Jeffrey Adijanto et al.   EXPERIMENTAL EYE RESEARCH

Intravitreal Sirolimus for the Treatment of Geographic Atrophy: Results of a Phase I/II Clinical Trial

(2014) P. A. Petrou et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium

(2014) B. Yu et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The Retinal Pigment Epithelium Utilizes Fatty Acids for Ketogenesis

(2014) Jeffrey Adijanto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data

(2013) Karan Uppal et al.   BMC BIOINFORMATICS

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

The multifaceted role of mTORC1 in the control of lipid metabolism

(2013) Stéphane J H Ricoult et al.   EMBO REPORTS

Hybrid Feature Detection and Information Accumulation Using High-Resolution LC–MS Metabolomics Data

(2013) Tianwei Yu et al.   JOURNAL OF PROTEOME RESEARCH

Oral Docosahexaenoic Acid in the Prevention of Exudative Age-Related Macular Degeneration

(2013) Eric H. Souied et al.   OPHTHALMOLOGY

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Predicting Network Activity from High Throughput Metabolomics

(2013) Shuzhao Li et al.   PLoS Computational Biology

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Age-Related Macular Degeneration Revisited – Piecing the Puzzle: The LXIX Edward Jackson Memorial Lecture

(2012) Joan W. Miller   AMERICAN JOURNAL OF OPHTHALMOLOGY

Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress

(2012) Yujuan Wang et al.   APOPTOSIS

Three-Dimensional Architecture of the Rod Sensory Cilium and Its Disruption in Retinal Neurodegeneration

(2012) Jared C. Gilliam et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Mutation in the  A3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

(2011) J. S. Zigler et al.   JOURNAL OF CELL SCIENCE

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Age-Related Retinopathy in NRF2-Deficient Mice

(2011) Zhenyang Zhao et al.   PLoS One

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

(2010) Chen Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

(2010) Calvin K. Yip et al.   MOLECULAR CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A RANDOMIZED PILOT STUDY OF SYSTEMIC IMMUNOSUPPRESSION IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION WITH CHOROIDAL NEOVASCULARIZATION

(2010) Robert B Nussenblatt et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Esterified Cholesterol Is Highly Localized to Bruch's Membrane, as Revealed by Lipid Histochemistry in Wholemounts of Human Choroid

(2009) Martin Rudolf et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Sterol Regulatory Element Binding Protein 1a Regulates Hepatic Fatty Acid Partitioning by Activating Acetyl Coenzyme A Carboxylase 2

(2009) S.-S. Im et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

The Relationship of Dietary ω-3 Long-Chain Polyunsaturated Fatty Acid Intake With Incident Age-Related Macular Degeneration

(2008) John Paul SanGiovanni   ARCHIVES OF OPHTHALMOLOGY

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE