Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies

Effects of Omega-3 Fatty Acids on Immune Cells

(2019) Saray Gutiérrez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

(2019) Madhvi Menon et al.   Nature Communications

mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model

(2018) Alice Polchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Composition of DHA and Very Long Chain PUFAs in Rod and Cone Photoreceptors

(2018) Martin-Paul G. Agbaga et al.   JOURNAL OF LIPID RESEARCH

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability

(2018) Ammaji Rajala et al.   Cell Death & Disease

Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration

(2018) Ammaji Rajala et al.   Cell Death & Disease

Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

(2018) Lolita Petit et al.   Cell Reports

Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium

(2018) Lei Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

(2018) Nicolas G. Bazan   MOLECULAR ASPECTS OF MEDICINE

The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment

(2017) Maartje J. Geerlings et al.   MOLECULAR IMMUNOLOGY

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

(2017) Nady Golestaneh et al.   Cell Death & Disease

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Glycolytic reliance promotes anabolism in photoreceptors

(2017) Yashodhan Chinchore et al.   eLife

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

(2017) Deborah A. Ferrington et al.   Redox Biology

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome

(2016) A Venkatesh et al.   Cell Death & Disease

Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy

(2016) Marina Zieger et al.   Oncotarget

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice

(2015) Aditya Venkatesh et al.   JOURNAL OF CLINICAL INVESTIGATION

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Omega-3 Fatty Acids and Age-Related Macular Degeneration

(2015) Eric H. Souied et al.   OPHTHALMIC RESEARCH

Age-Related Macular Degeneration: Genetics and Biology Coming Together

(2014) Lars G. Fritsche et al.   Annual Review of Genomics and Human Genetics

Intravitreal Sirolimus for the Treatment of Geographic Atrophy: Results of a Phase I/II Clinical Trial

(2014) P. A. Petrou et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium

(2014) B. Yu et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue

(2014) Milosz P. Kawa et al.   Journal of Immunology Research

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration

(2013)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High Concentrations of Plasma n3 Fatty Acids Are Associated with Decreased Risk for Late Age-Related Macular Degeneration

(2013) Bénédicte M. J. Merle et al.   JOURNAL OF NUTRITION

Dietary Omega-3 Fatty Acids, Other Fat Intake, Genetic Susceptibility, and Progression to Incident Geographic Atrophy

(2013) Robyn Reynolds et al.   OPHTHALMOLOGY

Age-Related Macular Degeneration Revisited – Piecing the Puzzle: The LXIX Edward Jackson Memorial Lecture

(2012) Joan W. Miller   AMERICAN JOURNAL OF OPHTHALMOLOGY

Identification of anti-retinal antibodies in patients with age-related macular degeneration

(2012) Kei Morohoshi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

RPE cell senescence: A key contributor to age-related macular degeneration

(2012) Michael R. Kozlowski   MEDICAL HYPOTHESES

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-chain and very long-chain polyunsaturated fatty acids in ocular aging and age-related macular degeneration

(2010) Aihua Liu et al.   JOURNAL OF LIPID RESEARCH

Chloride Intracellular Channel 4 Is Critical for the Epithelial Morphogenesis of RPE Cells and Retinal Attachment

(2010) Jen-Zen Chuang et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Abundant Lipid and Protein Components of Drusen

(2010) Lan Wang et al.   PLoS One

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors

(2009) R. Longbottom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE