Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats

(2018) Hong-feng Zhang et al.   ACTA PHARMACOLOGICA SINICA

Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3 inflammasome axis

(2018) Mei-ting Song et al.   ACTA PHARMACOLOGICA SINICA

Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy

(2018) Ze-bo Hu et al.   ACTA PHARMACOLOGICA SINICA

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Carbocisteine attenuates TNF-α-induced inflammation in human alveolar epithelial cells in vitro through suppressing NF-κB and ERK1/2 MAPK signaling pathways

(2016) Wei Wang et al.   ACTA PHARMACOLOGICA SINICA

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

(2016) K. Shahzad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro

(2015) Jing Wang et al.   ACTA PHARMACOLOGICA SINICA

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Caspase-11: arming the guards against bacterial infection

(2015) Irma Stowe et al.   IMMUNOLOGICAL REVIEWS

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling

(2015) M Zhang et al.   Cell Death & Disease

Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasome expression in BSA-overload nephropathy of rats

(2014) Li-hong Ding et al.   ACTA PHARMACOLOGICA SINICA

Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation

(2014) Qianwei Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures

(2014) Nadine Tarantino et al.   JOURNAL OF CELL BIOLOGY

Global toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy

(2014) Ishwarlal Jialal et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Targeting inflammation: New therapeutic approaches in chronic kidney disease (CKD)

(2014) Daniela Impellizzeri et al.   PHARMACOLOGICAL RESEARCH

Toll-like receptor activation: from renal inflammation to fibrosis

(2014) Wai Han Yiu et al.   Kidney International Supplements

Revisiting Caspase-11 Function in Host Defense

(2013) Tessie M. Ng et al.   Cell Host & Microbe

Caspase-11: The driving factor for noncanonical inflammasomes

(2013) Elena Viganò et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

(2013) Petr Broz et al.   PLoS Pathogens

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor

(2012) Benjamin Hansen et al.   CELLULAR SIGNALLING

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Angiotensin II as a Morphogenic Cytokine Stimulating Renal Fibrogenesis

(2011) C. Ruster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal fibrosis: novel insights into mechanisms and therapeutic targets

(2010) Peter Boor et al.   Nature Reviews Nephrology

Intrarenal angiotensin II is associated with inflammation, renal damage, and dysfunction in Dahl salt-sensitive hypertension

(2009) Lin Lin et al.   Journal of the American Society of Hypertension

Osteopontin modulates angiotensin II–induced inflammation, oxidative stress, and fibrosis of the kidney

(2009) Talya Wolak et al.   KIDNEY INTERNATIONAL

Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression

(2008) Qiu-gen Zhou et al.   ACTA PHARMACOLOGICA SINICA

Macrophage diversity in renal injury and repair

(2008) Sharon D. Ricardo et al.   JOURNAL OF CLINICAL INVESTIGATION