Hydroxychloroquine in rheumatic autoimmune disorders and beyond

CD154 Induces Interleukin-6 Secretion by Kidney Tubular Epithelial Cells under Hypoxic Conditions: Inhibition by Chloroquine

(2020) Antoine Dewitte et al.   MEDIATORS OF INFLAMMATION

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

(2020) Eva Schrezenmeier et al.   Nature Reviews Rheumatology

Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus

(2020) Linyu Geng et al.   Frontiers in Immunology

COVID-19, Arrhythmic Risk and Inflammation: Mind the Gap!

(2020) Pietro Enea Lazzerini et al.   CIRCULATION

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Review of trials currently testing treatment and prevention of COVID-19

(2020) Paraskevi C. Fragkou et al.   CLINICAL MICROBIOLOGY AND INFECTION

Clinical evidence for repurposing chloroquine and hydroxychloroquine as antiviral agents: a systematic review

(2020) Chaturaka Rodrigo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19)

(2020) Katelyn A Pastick et al.   Open Forum Infectious Diseases

Cardiac safety of off-label COVID-19 drug therapy: a review and proposed monitoring protocol

(2020) Niyada Naksuk et al.   European Heart Journal-Acute Cardiovascular Care

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19

(2020) Andrea Cortegiani et al.   JOURNAL OF CRITICAL CARE

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

(2020) David R. Boulware et al.   NEW ENGLAND JOURNAL OF MEDICINE

Candidate drugs against SARS-CoV-2 and COVID-19

(2020) Dwight L. McKee et al.   PHARMACOLOGICAL RESEARCH

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Hydroxychloroquine reverses the prothrombotic state in a mouse model of antiphospholipid syndrome: Role of reduced inflammation and endothelial dysfunction

(2019) Sébastien Miranda et al.   PLoS One

Pearls & Oy-sters: Hydroxychloroquine-induced toxic myopathy mimics Pompe disease

(2019) Saurabh Shukla et al.   NEUROLOGY

Autophagy in regulatory T cells: A double-edged sword in disease settings

(2019) Jing Zhang et al.   MOLECULAR IMMUNOLOGY

Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition

(2019) Shireen A. Hedya et al.   BEHAVIOURAL BRAIN RESEARCH

Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases

(2019) Tae-Yoon Park et al.   Scientific Reports

Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

(2018) Yasuhiro Kato et al.   ANNALS OF THE RHEUMATIC DISEASES

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Targeting autophagy in cancer

(2018) Angelique V. Onorati et al.   CANCER

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review

(2018) Domenico Plantone et al.   CLINICAL DRUG INVESTIGATION

Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition

(2018) Masataka Torigoe et al.   CLINICAL IMMUNOLOGY

Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature

(2018) Clotilde Chatre et al.   DRUG SAFETY

Hydroxychloroquine Inhibits the Differentiation of Th17 Cells in Systemic Lupus Erythematosus

(2018) Ji Yang et al.   JOURNAL OF RHEUMATOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Type I interferon in rheumatic diseases

(2018) Theresa L. Wampler Muskardin et al.   Nature Reviews Rheumatology

Cytokines as therapeutic targets in primary Sjögren syndrome

(2018) Soledad Retamozo et al.   PHARMACOLOGY & THERAPEUTICS

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

A novel anti-malarial drug derivative inhibits cyclic GMP-AMP synthase in Trex1 deficient mice

(2018) Jie An et al.   Arthritis & Rheumatology

Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy

(2018) Enric Mocholi et al.   Cell Reports

Re-purposing Chloroquine for Glioblastoma: Potential Merits and Confounding Variables

(2018) Patrick Weyerhäuser et al.   Frontiers in Oncology

Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages

(2018) Yong Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hydroxychloroquine retinopathy — implications of research advances for rheumatology care

(2018) April Jorge et al.   Nature Reviews Rheumatology

Hydroxychloroquine retinopathy: an emerging problem

(2017) M Latasiewicz et al.   EYE

Hydroxychloroquine retinopathy

(2017) I H Yusuf et al.   EYE

Chloroquine (CQ) exerts anti-breast cancer through modulating microenvironment and inducing apoptosis

(2017) Yanjun Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Accumulation of autophagosomes confers cytotoxicity

(2017) Robert W. Button et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloroquine attenuates TLR3/IFN-β signaling in cultured normal human mesangial cells: A possible protective effect against renal damage in lupus nephritis

(2017) Tadaatsu Imaizumi et al.   Modern Rheumatology

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus

(2017) Jie An et al.   Arthritis & Rheumatology

Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation

(2017) Ralf L. J. Schmidt et al.   Scientific Reports

Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine

(2017) María Eugenia Schroeder et al.   Scientific Reports

Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis

(2017) Sergey A. Shiryaev et al.   Scientific Reports

Historical Review: Problematic Malaria Prophylaxis with Quinine

(2016) G. Dennis Shanks   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase

(2016) Nadine Müller-Calleja et al.   ANNALS OF THE RHEUMATIC DISEASES

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Reproductive outcomes following hydroxychloroquine use for autoimmune diseases: a systematic review and meta-analysis

(2016) Yusuf Cem Kaplan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Research progress of hydroxychloroquine and autophagy inhibitors on cancer

(2016) Ting-Ting Shi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair

(2016) Diana H. Liang et al.   CANCER LETTERS

Increased autophagy in CD4+T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance

(2016) Jorg van Loosdregt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies

(2016) Steve Pascolo   EUROPEAN JOURNAL OF PHARMACOLOGY

Hydroxychloroquine in systemic lupus erythematosus (SLE)

(2016) C. Ponticelli et al.   Expert Opinion On Drug Safety

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Effect of Hydroxychloroquine Treatment on Dry Eyes in Subjects with Primary Sjögren's Syndrome: a Double-Blind Randomized Control Study

(2016) Chang Ho Yoon et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2

(2016) Chenghao Xu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models

(2016) Rodrigo Delvecchio et al.   Viruses-Basel

Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes

(2016) Rachel Barrow-McGee et al.   Nature Communications

Rapid Onset of Retinal Toxicity From High-Dose Hydroxychloroquine Given for Cancer Therapy

(2015) Loh-Shan B. Leung et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation

(2015) Chi G Weindel et al.   Autophagy

Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells

(2015) Ting Chan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy inhibitors

(2015) Benoit Pasquier   CELLULAR AND MOLECULAR LIFE SCIENCES

Chloroquine Inhibits Ca2+ Signaling in Murine CD4+ Thymocytes

(2015) Jin-Chao Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases

(2015) M. A. A. Al-Bari   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction

(2015) Jie An et al.   JOURNAL OF IMMUNOLOGY

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Antiviral Activity of Chloroquine Against Dengue Virus Type 2 Replication inAotusMonkeys

(2015) Kleber Juvenal Silva Farias et al.   VIRAL IMMUNOLOGY

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

(2015) K. D. Rainsford et al.   INFLAMMOPHARMACOLOGY

Targeting Autophagy Addiction in Cancer

(2015) Joseph D. Mancias et al.   Oncotarget

Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity

(2014) Siwaporn Boonyasuppayakorn et al.   ANTIVIRAL RESEARCH

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

Hydroxychloroquine-Induced Cardiomyopathy: Case Report, Pathophysiology, Diagnosis, and Treatment

(2014) Haran Yogasundaram et al.   CANADIAN JOURNAL OF CARDIOLOGY

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Danon Disease

(2014) Ryan S. D’souza et al.   Circulation-Heart Failure

Chronic Hydroxychloroquine Improves Endothelial Dysfunction and Protects Kidney in a Mouse Model of Systemic Lupus Erythematosus

(2014) Manuel Gómez-Guzmán et al.   HYPERTENSION

Effects of Hydroxychloroquine on Symptomatic Improvement in Primary Sjögren Syndrome

(2014) Jacques-Eric Gottenberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Influenza Promotes Collagen Deposition via αvβ6 Integrin-mediated Transforming Growth Factor β Activation

(2014) Lisa Jolly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

(2014) A. Balic et al.   MOLECULAR CANCER THERAPEUTICS

Chloroquine inhibits MGC803 gastric cancer cell migration via the Toll-like receptor 9/nuclear factor kappa B signaling pathway

(2014) YANLI ZHANG et al.   Molecular Medicine Reports

Hydroxychloroquine: A multifaceted treatment in lupus

(2014) Nathalie Costedoat-Chalumeau et al.   PRESSE MEDICALE

Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1

(2014) Dong Soon Choi et al.   STEM CELLS

Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors

(2014) J. M. M. Levy et al.   Cancer Discovery

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

(2013) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients

(2013) JC Silva et al.   Clinics

Chloroquine Engages the Immune System to Eradicate Irradiated Breast Tumors in Mice

(2013) Josephine Anna Ratikan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Expression of Toll-like receptor-9 is associated with poor progression-free survival in prostate cancer

(2013) MARJA-RIITTA VÄISÄNEN et al.   Oncology Letters

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

The deviated balance between regulatory T cell and Th17 in autoimmunity

(2012) Farhad Jadidi-Niaragh et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Effect of hydroxychloroquine treatment on pro-inflammatory cytokines and disease activity in SLE patients: data from LUMINA (LXXV), a multiethnic US cohort

(2012) R Willis et al.   LUPUS

Identification of Anti-Malarial Compounds as Novel Antagonists to Chemokine Receptor CXCR4 in Pancreatic Cancer Cells

(2012) Joseph Kim et al.   PLoS One

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine

(2011) Michel Michaelides   ARCHIVES OF OPHTHALMOLOGY

Akt and p53 are potential mediators of reduced mammary tumor growth by Chloroquine and the mTOR inhibitor RAD001

(2011) Christian R. Loehberg et al.   BIOCHEMICAL PHARMACOLOGY

Hydroxychloroquine: From Malaria to Autoimmunity

(2011) Ilan Ben-Zvi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

(2011) E. L. Kim et al.   NEURO-ONCOLOGY

Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus

(2011) J. Yang et al.   RHEUMATOLOGY

Lysosomotropic agents as HCV entry inhibitors

(2011) Usman A Ashfaq et al.   Virology Journal

Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer

(2010) Pei-Du Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

(2010) Xueqing Sun et al.   CANCER AND METASTASIS REVIEWS

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Chloroquine inhibits T cell proliferation by interfering with IL-2 production and responsiveness

(2010) R. B. M. LANDEWE et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Assessment of in vitro prophylactic and therapeutic efficacy of chloroquine against chikungunya virus in vero cells

(2010) Mohsin Khan et al.   JOURNAL OF MEDICAL VIROLOGY

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

Cytokines as therapeutic targets in SLE

(2010) Lars Rönnblom et al.   Nature Reviews Rheumatology

Phagocytosis of Retinal Rod and Cone Photoreceptors

(2010) Brian M. Kevany et al.   PHYSIOLOGY

Hydroxychloroquine improves dry eye symptoms of patients with primary Sjogren’s syndrome

(2010) Sule Yavuz et al.   RHEUMATOLOGY INTERNATIONAL

Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus

(2010) György Nagy et al.   ARTHRITIS RESEARCH & THERAPY

Elevated Golgi pH impairs terminalN-glycosylation by inducing mislocalization of Golgi glycosyltransferases

(2009) Antti Rivinoja et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Treatment of sicca symptoms with hydroxychloroquine in patients with Sjogren's syndrome

(2009) M. Rihl et al.   RHEUMATOLOGY

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

(2008) G Ruiz-Irastorza et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

BAFF-targeting therapy, a promising strategy for treating autoimmune diseases

(2008) Jian Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

(2007) Kirsteen H. Maclean et al.   JOURNAL OF CLINICAL INVESTIGATION