Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells

(2018) Kei Takahashi et al.   ONCOGENE

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer

(2018) Lucy Ireland et al.   ONCOGENE

Lup-20(29)-en-3β,28-di-yl-nitrooxy acetate affects MCF-7 proliferation through the crosstalk between apoptosis and autophagy in mitochondria

(2018) Xiaoning Yan et al.   Cell Death & Disease

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

(2018) Melissa A. Meyer et al.   Nature Communications

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

(2018) Alexia Karen Cotte et al.   Nature Communications

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

(2018) Hai Wang et al.   Nature Communications

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

(2018) Qirui Wang et al.   Nature Communications

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

(2018) Rajani Ravi et al.   Nature Communications

Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs

(2018) Jorge Vallecillo-Hernández et al.   Scientific Reports

Lysosomotropism depends on glucose: a chloroquine resistance mechanism

(2017) Laura E Gallagher et al.   Cell Death & Disease

The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma

(2017) Sam Sheppard et al.   Nature Communications

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

(2017) Junchao Cai et al.   Nature Communications

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery

(2017) Joy Wolfram et al.   Scientific Reports

Therapeutic effect of hydroxychloroquine on colorectal carcinogenesis in experimental murine colitis

(2016) Junlin Yao et al.   BIOCHEMICAL PHARMACOLOGY

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer

(2016) Michela Serresi et al.   CANCER CELL

Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies

(2016) Steve Pascolo   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis

(2016) A Ruiz et al.   Cell Death & Disease

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells

(2016) Zheng-Hai Tang et al.   Scientific Reports

A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation

(2016) Guoliang Zhang et al.   OncoImmunology

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

(2016) Anoop Babu Vasandan et al.   Scientific Reports

CTL- vs Treg lymphocyte-attracting chemokines, CCL4 and CCL20, are strong reciprocal predictive markers for survival of patients with oesophageal squamous cell carcinoma

(2015) J Y Liu et al.   BRITISH JOURNAL OF CANCER

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Refining the treatment of NSCLC according to histological and molecular subtypes

(2015) Anish Thomas et al.   Nature Reviews Clinical Oncology

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Systems assessment of intercalated combination of chemotherapy and EGFR TKIs versus chemotherapy or EGFR TKIs alone in advanced NSCLC patients

(2015) Han Yan et al.   Scientific Reports

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

(2015) Benny Zhitomirsky et al.   Oncotarget

Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro

(2014) Fang Liu et al.   ACTA PHARMACOLOGICA SINICA

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Activation-induced CD137 is a fast assay for identification and multi-parameter flow cytometric analysis of alloreactive T cells

(2013) N. H. R. Litjens et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78

(2013) H-Y Tsai et al.   ONCOGENE

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

(2013) Sílvia Cufí et al.   Scientific Reports

A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non–Small-Cell Lung Cancer

(2012) Sarah B. Goldberg et al.   Journal of Thoracic Oncology

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy

(2011) M Bartucci et al.   CELL DEATH AND DIFFERENTIATION

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer

(2008) H E Lee et al.   BRITISH JOURNAL OF CANCER