Identification of Anti-Malarial Compounds as Novel Antagonists to Chemokine Receptor CXCR4 in Pancreatic Cancer Cells

HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells

(2014) Mélanie Denizot et al.   Autophagy

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Homogeneous time-resolved fluorescence-based assay to screen for ligands targeting the growth hormone secretagogue receptor type 1a

(2010) Jean-Philippe Leyris et al.   ANALYTICAL BIOCHEMISTRY

Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

(2010) Kazuhito Sasaki et al.   BMC CANCER

CXCL12–CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy

(2010) S Singh et al.   BRITISH JOURNAL OF CANCER

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

The Peptidomimetic CXCR4 Antagonist TC14012 Recruits β-Arrestin to CXCR7

(2010) Stéphanie Gravel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of Receptor Flexibility in Binding of Cyclam Compounds to the Chemokine Receptor CXCR4

(2010) Alfonso R. Lam et al.   Journal of Chemical Information and Modeling

Computational Mapping of the Conformational Transitions in Agonist Selective Pathways of a G-Protein Coupled Receptor

(2010) Supriyo Bhattacharya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metastatic pancreatic cancer: Is gemcitabine still the best standard treatment? (Review)

(2010) Di Marco   ONCOLOGY REPORTS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

Chemokine Receptor CXCR4 Enhances Proliferation in Pancreatic Cancer Cells Through AKT and ERK Dependent Pathways

(2009) Xiaoming Shen et al.   PANCREAS

Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor

(2009) Peter J. McCormick et al.   PLoS One

Comparison of the Potential Multiple Binding Modes of Bicyclam, Monocylam, and Noncyclam Small-Molecule CXC Chemokine Receptor 4 Inhibitors

(2008) R. S. Y. Wong et al.   MOLECULAR PHARMACOLOGY

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

(2007) Kirsteen H. Maclean et al.   JOURNAL OF CLINICAL INVESTIGATION