Production of allergen-specific immunotherapeutic agents for the treatment of food allergy

Peanut Oral Immunotherapy: a Current Perspective

(2020) Meera Patrawala et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Recombinant allergens for immunotherapy

(2019) Yury Zhernov et al.   Current Opinion in Allergy and Clinical Immunology

Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety

(2019) Derek K Chu et al.   LANCET

Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?

(2019) Laure Castan et al.   ALLERGY

Recent developments and highlights in food allergy

(2019) Thomas Eiwegger et al.   ALLERGY

Conflicting verdicts on peanut oral immunotherapy from the Institute for Clinical and Economic Review and US Food and Drug Administration Advisory Committee: Where do we go from here?

(2019) Thomas Eiwegger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical reactivity of celery cultivars in allergic patients: Role of Api g 1

(2018) S. Dölle et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Animal models of allergen-specific immunotherapy in food allergy: Overview and opportunities

(2018) Jeppe Madura Larsen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Impact of Baked Egg and Baked Milk Diets on IgE- and Non-IgE-Mediated Allergy

(2018) Julia Upton et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Altering allergenicity of cow's milk by food processing for applications in infant formula

(2018) Abdolkhalegh Golkar et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Effect of boiling on the structure and immunoreactivity of recombinant peanut protein Ara h 1

(2018) Yang Tian et al.   FOOD AND AGRICULTURAL IMMUNOLOGY

Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity) from new or modified dietary proteins

(2018) B. Remington et al.   FOOD AND CHEMICAL TOXICOLOGY

Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial

(2018) J. Andrew Bird et al.   Journal of Allergy and Clinical Immunology-In Practice

Chemically modified peanut extract shows increased safety while maintaining immunogenicity

(2018) Hanneke P. M. van der Kleij et al.   ALLERGY

AR101 Oral Immunotherapy for Peanut Allergy

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Expression of recombinant parvalbumin from wolf-herring fish and determination of its IgE-binding capability

(2017) Mohsen Mohammadi et al.   FOOD AND AGRICULTURAL IMMUNOLOGY

Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity

(2017) Hugh A. Sampson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Peanut oleosins associated with severe peanut allergy—importance of lipophilic allergens for comprehensive allergy diagnostics

(2017) Christian Schwager et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults

(2017) Stacie M. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy

(2017) Julia Anzengruber et al.   MOLECULAR IMMUNOLOGY

The Use of a Tobacco mosaic virus-Based Expression Vector System in Chrysanthemum

(2017) Minju Park et al.   Plant Pathology Journal

Hypoallergenic Variant of the Major Egg White Allergen Gal d 1 Produced by Disruption of Cysteine Bridges

(2017) Pathum Dhanapala et al.   Nutrients

A 12-week DBPC dose-finding study with sublingual monomeric allergoid tablets in house dust mite-allergic patients

(2016) C. Hüser et al.   ALLERGY

The Heterogeneity of Oral Immunotherapy Clinical Trials: Implications and Future Directions

(2016) Christina S. K. Yee et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Standardization and Regulation of Allergen Products in the European Union

(2016) Julia Zimmer et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Food allergy quality of life and living with food allergy

(2016) Matthew Greenhawt   Current Opinion in Allergy and Clinical Immunology

Comparison of allergenic extracts from different origins: the value of the FDA’s bioequivalent allergy unit (BAU)

(2016) Giovanni Passalacqua et al.   Expert Review of Clinical Immunology

Safety of epicutaneous immunotherapy for the treatment of peanut allergy: A phase 1 study using the Viaskin patch

(2016) Stacie M. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics

(2016) Marek Jutel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Food allergy and the gut

(2016) Anna Nowak-Wegrzyn et al.   Nature Reviews Gastroenterology & Hepatology

Immunotherapy using algal-produced Ara h 1 core domain suppresses peanut allergy in mice

(2016) James A. Gregory et al.   PLANT BIOTECHNOLOGY JOURNAL

Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis

(2016) Robert J Boyle et al.   BMJ-British Medical Journal

Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis

(2016) Robert J Boyle et al.   BMJ-British Medical Journal

Current challenges facing the assessment of the allergenic capacity of food allergens in animal models

(2016) Katrine Lindholm Bøgh et al.   Clinical and Translational Allergy

Effect of chemical modifications on allergenic potency of peanut proteins

(2015) Ramon Bencharitiwong et al.   ALLERGY AND ASTHMA PROCEEDINGS

Expression of a codon-optimised recombinant Ara h 2.02 peanut allergen in Escherichia coli

(2015) Min Han Lew et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Immunoregulatory T cell epitope peptides: the new frontier in allergy therapy

(2015) S. R. Prickett et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Early sustained unresponsiveness after short-course egg oral immunotherapy: a randomized controlled study in egg-allergic children

(2015) C. Escudero et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Food processing and allergenicity

(2015) Kitty C.M. Verhoeckx et al.   FOOD AND CHEMICAL TOXICOLOGY

Development of a Hypoallergenic Recombinant Parvalbumin for First-in-Man Subcutaneous Immunotherapy of Fish Allergy

(2015) Laurian Zuidmeer-Jongejan et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy

(2015) Satya D. Narisety et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial

(2015) A. Wesley Burks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen-Specific Immunotherapy with Monomeric Allergoid in a Mouse Model of Atopic Dermatitis

(2015) Nadezda Shershakova et al.   PLoS One

Characterization of the Immunogenicity and Allergenicity of Two Cow's Milk Hydrolysates - A Study in Brown Norway Rats

(2015) K. L. Bøgh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up

(2015) Lucia Caminiti et al.   Journal of Allergy and Clinical Immunology-In Practice

Automated solid-phase peptide synthesis to obtain therapeutic peptides

(2014) Veronika Mäde et al.   Beilstein Journal of Organic Chemistry

Identification of novel IgE-binding soybean allergens using serological analysis of a recombinant cDNA expression library (SEREX)

(2014) Jae-Hwan Kim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

(2014) Scott H. Sicherer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Assessment of the Sensitizing Potential of Processed Peanut Proteins in Brown Norway Rats: Roasting Does Not Enhance Allergenicity

(2014) Stine Kroghsbo et al.   PLoS One

Fusion tags for protein solubility, purification and immunogenicity in Escherichia coli: the novel Fh8 system

(2014) Sofia Costa et al.   Frontiers in Microbiology

Recombinant protein expression in Escherichia coli: advances and challenges

(2014) Germán L. Rosano et al.   Frontiers in Microbiology

The impact of structural integrity and route of administration on the antibody specificity against three cow’s milk allergens - a study in Brown Norway rats

(2014) Jeanette Madsen et al.   Clinical and Translational Allergy

A phase 1 study of heat/phenol-killed,E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy

(2013) R. A. Wood et al.   ALLERGY

Immunotherapy Preparation Guidelines, Rules, and Regulation

(2013) Robert E. Esch et al.   CURRENT ALLERGY AND ASTHMA REPORTS

IgE-mediated food allergy in children

(2013) Giorgio Longo et al.   LANCET

Production and analysis of recombinant tree nut allergens

(2013) LeAnna N. Willison et al.   METHODS

An analysis of the factors that affect the dissociation of inclusion bodies and the refolding of endostatin under high pressure

(2013) R.M. Chura-Chambi et al.   PROCESS BIOCHEMISTRY

Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides

(2013) Céline Pellaton et al.   Clinical and Translational Allergy

A novel peanut allergoid is safe and effective in immunotherapy in a peanut allergy mouse model

(2013) J Smit et al.   Clinical and Translational Allergy

A global survey of changing patterns of food allergy burden in children

(2013) Susan L Prescott et al.   World Allergy Organization Journal

Specific oral tolerance induction in paediatric patients with persistent egg allergy

(2012) V. Fuentes-Aparicio et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

The Sensitising Capacity of Intact �-Lactoglobulin Is Reduced by Co-Administration with Digested �-Lactoglobulin

(2012) Katrine Lindholm Bøgh et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Effect of polymerization with transglutaminase on in vitro digestion and antigenicity of β-lactoglobulin

(2012) Mariana Battaglin Villas-Boas et al.   INTERNATIONAL DAIRY JOURNAL

Sublingual immunotherapy for peanut allergy: A randomized, double-blind, placebo-controlled multicenter trial

(2012) David M. Fleischer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of recombinant Ara h 6 in Pichia pastoris but not in Escherichia coli preserves allergic effector function and allows assessment of specific mutations

(2012) Yonghua Zhuang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Regulation of Pichia pastoris promoters and its consequences for protein production

(2012) Thomas Vogl et al.   New Biotechnology

Oral Immunotherapy for Treatment of Egg Allergy in Children

(2012) A. Wesley Burks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity

(2011) G. A. Mueller et al.   ALLERGY

Microbial transglutaminase-mediated modification of ovalbumin

(2011) C.V.L. Giosafatto et al.   FOOD HYDROCOLLOIDS

Cloning, Expression and Patient IgE Reactivity of Recombinant Pru du 6, an 11S Globulin from Almond

(2011) LeAnna N. Willison et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Cloning and Characterization of an 11S Legumin, Car i 4, a Major Allergen in Pecan

(2011) Girdhari M. Sharma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cloning and Characterization of 2S Albumin, Car i 1, a Major Allergen in Pecan

(2011) Girdhari M. Sharma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization

(2011) Edwin H. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression and Purification of Peanut Oleosins in Insect Cells

(2011) Cerrone Cabanos et al.   PROTEIN JOURNAL

Watermelon Profilin: Characterization of a Major Allergen as a Model for Plant-Derived Food Profilins

(2010) Bárbara Cases et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

The effect of transglutaminase-induced polymerization in the presence of cysteine on β-lactoglobulin antigenicity

(2010) Mariana Battaglin Villas-Boas et al.   INTERNATIONAL DAIRY JOURNAL

Cow's milk epicutaneous immunotherapy in children: A pilot trial of safety, acceptability, and impact on allergic reactivity

(2010) Christophe Dupont et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ara h 2 peptides containing dominant CD4+ T-cell epitopes: Candidates for a peanut allergy therapeutic

(2010) Sara R. Prickett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Isolation of biologically active nanomaterial (inclusion bodies) from bacterial cells

(2010) Špela Peternel et al.   Microbial Cell Factories

Isolation, cloning, and characterization of the 2S albumin: A new allergen from hazelnut

(2010) Cristiano Garino et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cloning, Expression, Characterization, and Computational Approach for Cross-Reactivity Prediction of Manganese Superoxide Dismutase Allergen from Pistachio Nut

(2010) Reihaneh Noorbakhsh et al.   ALLERGOLOGY INTERNATIONAL

Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract

(2009) M. Fernández-Rivas et al.   ALLERGY

The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut

(2009) I. Lauer et al.   CLINICAL AND EXPERIMENTAL ALLERGY

nsLTP and profilin are allergens in mustard seeds: cloning, sequencing and recombinant production of Sin a 3 and Sin a 4

(2009) S. Sirvent et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Allergy Therapy by Intranasal Administration with Recombinant Lactococcus lactis Producing Bovine β-Lactoglobulin

(2009) Naima G. Cortes-Perez et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Expression of Jug r 1, the 2S albumin allergen from walnut (Juglans regia), as a correctly folded and functional recombinant protein

(2009) Camille Sordet et al.   PEPTIDES

GATEWAY™ technology and E. coli recombinant system produce a properly folded and functional recombinant allergen of the lipid transfer protein of apple (Mal d 3)

(2009) Jean-Philippe Borges et al.   PROTEIN EXPRESSION AND PURIFICATION

Pichia pastoris is superior to E. coli for the production of recombinant allergenic non-specific lipid-transfer proteins

(2009) Sven Pokoj et al.   PROTEIN EXPRESSION AND PURIFICATION

Studies on bacterial inclusion bodies

(2008) Natalia S de Groot et al.   Future Microbiology

A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy

(2008) Justin M. Skripak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protein purification using chromatography: selection of type, modelling and optimization of operating conditions

(2008) J. A. Asenjo et al.   JOURNAL OF MOLECULAR RECOGNITION