Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome

Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug–Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial

(2016) Ema Washio et al.   Clinical Gastroenterology and Hepatology

NSAID-Induced Small Intestinal Damage - Roles of Various Pathogenic Factors

(2015) Koji Takeuchi et al.   DIGESTION

Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy

(2015) A Higashimori et al.   Mucosal Immunology

New insights into the use of currently available non-steroidal anti-inflammatory drugs

(2015) Brune et al.   Journal of Pain Research

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Risk factors for small-bowel mucosal breaks in chronic low-dose aspirin users: data from a prospective multicenter capsule endoscopy registry

(2014) Hiroki Endo et al.   GASTROINTESTINAL ENDOSCOPY

Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage

(2013) Toshio Watanabe et al.   DIGESTIVE AND LIVER DISEASE

Role of Phospholipids in Protection of the GI Mucosa

(2013) Lenard M. Lichtenberger   DIGESTIVE DISEASES AND SCIENCES

Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients

(2013) Toshio Watanabe et al.   GUT

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

High Mobility Group Box 1 Promotes Small Intestinal Damage Induced by Nonsteroidal Anti-Inflammatory Drugs through Toll-Like Receptor 4

(2012) Yuji Nadatani et al.   AMERICAN JOURNAL OF PATHOLOGY

Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis

(2011) John L. Wallace et al.   GASTROENTEROLOGY

Mitochondrial disorders in NSAIDs-induced small bowel injury

(2011) Toshio Watanabe et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Colchicine for the treatment of gout

(2010) Pascal Richette et al.   EXPERT OPINION ON PHARMACOTHERAPY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colchicine Revisited

(2009) Anupama Bhat et al.   Annals of the New York Academy of Sciences

Evaluation of Small Bowel Injury in Patients with Rheumatoid Arthritis by Capsule Endoscopy: Effects of Anti-Rheumatoid Arthritis Drugs

(2009) Satoshi Sugimori et al.   DIGESTION

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE