Piperine Suppresses Pyroptosis and Interleukin-1β Release upon ATP Triggering and Bacterial Infection

Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders

(2016) Kuo-Hui Su et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice

(2016) Zhongshuang Hu et al.   INTERNATIONAL IMMUNOLOGY

Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome

(2016) Yara A. Samra et al.   LIFE SCIENCES

NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis

(2016) Yongfeng Zhang et al.   MEDIATORS OF INFLAMMATION

Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway

(2016) Qiu-Ru Lin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration

(2016) Georg Gdynia et al.   Nature Communications

Translating dosages from animal models to human clinical trials—revisiting body surface area scaling

(2015) Otis L. Blanchard et al.   FASEB JOURNAL

HIF1α Allows Monocytes to Take a Breather during Sepsis

(2015) Derek W. Gilroy et al.   IMMUNITY

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium

(2015) Vivien I. Maltez et al.   IMMUNITY

Inflammasomes and human autoimmunity: A comprehensive review

(2015) Chin-An Yang et al.   JOURNAL OF AUTOIMMUNITY

Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice

(2015) Rohit A. Gupta et al.   JOURNAL OF ETHNOPHARMACOLOGY

Piperine inhibit inflammation, alveolar bone loss and collagen fibers breakdown in a rat periodontitis model

(2015) Y. Dong et al.   JOURNAL OF PERIODONTAL RESEARCH

Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats

(2015) Xin Di et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection

(2015) Hao Pan et al.   Oncotarget

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

(2014) Yun Wang et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats

(2014) Parim BrahmaNaidu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Toll-Like Receptor-Triggered Calcium Mobilization Protects Mice against Bacterial Infection through Extracellular ATP Release

(2014) Hua Ren et al.   INFECTION AND IMMUNITY

Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

(2014) Barbara Wegiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective Role for Caspase-11 during Acute Experimental Murine Colitis

(2014) Katarzyna Oficjalska et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

(2014) D Demon et al.   Mucosal Immunology

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Revisiting caspases in sepsis

(2014) M Aziz et al.   Cell Death & Disease

Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

(2014) Bénédicte F. Py et al.   Cell Reports

Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice

(2013) Qing-Qiu Mao et al.   BEHAVIOURAL BRAIN RESEARCH

Release of extracellular ATP by bacteria during growth

(2013) Roberto Mempin et al.   BMC MICROBIOLOGY

Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen induced arthritis

(2013) Sadiq Umar et al.   CELLULAR IMMUNOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte

(2013) Xiaozhou Ying et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

How Metabolism Generates Signals during Innate Immunity and Inflammation

(2013) Anne F. McGettrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis

(2012) A.W.S. de Souza et al.   AUTOIMMUNITY REVIEWS

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

Anti-inflammatory Effect of Piperine in Adjuvant-Induced Arthritic Rats—a Biochemical Approach

(2012) Vachana Murunikkara et al.   INFLAMMATION

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Sensing of energy and nutrients by AMP-activated protein kinase

(2011) D Grahame Hardie   AMERICAN JOURNAL OF CLINICAL NUTRITION

Piperine ameliorates the severity of cerulein-induced acute pancreatitis by inhibiting the activation of mitogen activated protein kinases

(2011) Gi-Sang Bae et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils

(2011) Hong-Beom Bae et al.   FASEB JOURNAL

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Deregulated inflammasome signaling in disease

(2011) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Enhancing the bioavailability of resveratrol by combining it with piperine

(2011) Jeremy J. Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

(2011) Ivonne Ceballos-Olvera et al.   PLoS Pathogens

Inhibition of lipopolysaccharide-induced inflammatory responses by piperine

(2010) Gi-Sang Bae et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Basis for the Medicinal Use of Black Pepper and Piperine in Gastrointestinal Disorders

(2010) Malik Hassan Mehmood et al.   JOURNAL OF MEDICINAL FOOD

Piperine, the potential functional food for mood and cognitive disorders

(2008) Jintanaporn Wattanathorn et al.   FOOD AND CHEMICAL TOXICOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL