Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

Hyperglycemia-induced transcriptional regulation of ROCK1 and TGM2 expression is involved in small artery remodeling in obese diabetic Göttingen Minipigs

(2020) Trine Pagh Ludvigsen et al.   CLINICAL SCIENCE

Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

(2019) Maria Calvo-Rodriguez et al.   Frontiers in Cellular Neuroscience

Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis

(2019) Ashley Mulcahy Toney et al.   Obesity

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p

(2019) Shaqiu Zhang et al.   Frontiers in Immunology

The Ellagitannin Metabolite Urolithin C is a Glucose‐Dependent Regulator of Insulin Secretion through L‐type Calcium Channel Activation

(2019) Morgane Bayle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Perturbed mitochondria-ER contacts in live neurons modelling Alzheimer's disease amyloid pathology

(2019) Pamela V. Martino Adami et al.   JOURNAL OF CELL SCIENCE

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

(2019) Małgorzata Kujawska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages

(2018) Yaw Duah Boakye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome

(2018) María V. Selma et al.   CLINICAL NUTRITION

Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia

(2018) Gyeongjin Lee et al.   PHYTOMEDICINE

MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells

(2018) Ghodratollah Panahi et al.   PLoS One

IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

(2018) Han Xu et al.   BMC Nephrology

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

(2018) Enming Zhang et al.   Cell Metabolism

Transglutaminase Type 2 Regulates ER-Mitochondria Contact Sites by Interacting with GRP75

(2018) Manuela D’Eletto et al.   Cell Reports

Enhancement of high glucose-induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT2 /Akt/NF-κB pathway

(2017) Xaykham Onphachanh et al.   JOURNAL OF PINEAL RESEARCH

Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells

(2017) Wenhua Zhao et al.   MOLECULAR CARCINOGENESIS

Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes: a national cohort

(2017) Ghada Bourjeily et al.   SLEEP MEDICINE

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid

(2017) María V. Selma et al.   Frontiers in Microbiology

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target

(2017) Amadou K. S. Camara et al.   Frontiers in Physiology

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2016) Antonio González-Sarrías et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation and Neurodegeneration via Augmented Tuberous Sclerosis Complex-2 (TSC-2) Activation in Neuronal Cells

(2016) Premranjan Kumar et al.   MOLECULAR NEUROBIOLOGY

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

(2015) Tao Yuan et al.   ACS Chemical Neuroscience

High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation

(2015) Sujith Dassanayaka et al.   BIOCHEMICAL JOURNAL

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes-associated dysregulation ofO-GlcNAcylation in rat cardiac mitochondria

(2015) Partha S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

Mitochondrial import and degradation of amyloid-β peptide

(2014) Catarina Moreira Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut

(2014) M. V. Selma et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials

(2014) Jakub P. Piwowarski et al.   JOURNAL OF ETHNOPHARMACOLOGY

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

(2013) Juan Carlos Espín et al.   Evidence-based Complementary and Alternative Medicine

Time Course Production of Urolithins from Ellagic Acid by Human Gut Microbiota

(2013) Rocío García-Villalba et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High Glucose Promotes Aβ Production by Inhibiting APP Degradation

(2013) Yi Yang et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AIP and its interacting partners

(2011) Giampaolo Trivellin et al.   JOURNAL OF ENDOCRINOLOGY

Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites

(2011) Elena Verzelloni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

(2010) Sashi G. Kasimsetty et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Aryl Hydrocarbon Receptor-interacting Protein (AIP) Is Required for Dioxin-induced Hepatotoxicity but Not for the Induction of theCyp1a1andCyp1a2Genes

(2010) Manabu Nukaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Tissue transglutaminase inhibition as treatment for diabetic glomerular scarring: it's good to be glueless

(2009) Jeffrey R. Schelling   KIDNEY INTERNATIONAL

Aryl Hydrocarbon Receptor Is Activated by Glucose and Regulates the Thrombospondin-1 Gene Promoter in Endothelial Cells

(2008) Pankaj Dabir et al.   CIRCULATION RESEARCH

Glucose neurotoxicity

(2007) David R. Tomlinson et al.   NATURE REVIEWS NEUROSCIENCE